Research in Medical Biophysics Publications focuses on the application of physics in the human body and those of higher animals while examining topics such as blood flow, orthopedic mechanics, medical imaging and cancer biology. Research is conducted in partnership with clinicians at state-of-the-art facilities located at Western University, London Regional Cancer Program, Lawson Health Research Institute, Robarts Research Institute, and the London Health Sciences Centre.

Visit the Department of Medical Biophysics website for additional information.

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Submissions from 2019

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification, Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, and Tom Montine

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways, Emrin Horgusluoglu-Moloch, Shannon L. Risacher, Paul K. Crane, Derrek Hibar, Paul M. Thompson, Andrew J. Saykin, Kwangsik Nho, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, and Adam Fleisher

Quantifying joint blood flow in a rat model of rheumatoid arthritis with dynamic contrast-enhanced near-infrared spectroscopy, Seva Ioussoufovitch, Laura B. Morrison, Lise Desjardins, Jennifer A. Hadway, Keith St Lawrence, Ting Yim Lee, Frank Beier, and Mamadou Diop

Incorporating Pathology-Induced Heterogeneities in a Patient-Specific Biomechanical Model of the Lung for Accurate Tumor Motion Estimation., Parya Jafari, Douglas A Hoover, Brian P Yaremko, Grace Parraga, Abbas Samani, and Ali Sadeghi-Naini

4DCT Ventilation Map Construction Using Biomechanics-base Image Registration and Enhanced Air Segmentation., Parya Jafari, Brian P Yaremko, Grace Parraga, Douglas A Hoover, Ali Sadeghi-Naini, and Abbas Samani

Robust, Intrinsic Tracking of a Laparoscopic Ultrasound Probe for Ultrasound-Augmented Laparoscopy, Uditha L. Jayarathne, Elvis C.S. Chen, John Moore, and Terry M. Peters

Conditional generative adversarial network for 3D rigid-body motion correction in MRI, Patricia M. Johnson and Maria Drangova

Rigid-body motion correction in hybrid PET/MRI using spherical navigator echoes, P. M. Johnson, R. Taylor, T. Whelan, J. D. Thiessen, U. Anazodo, and M. Drangova

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Semiautomated Assessment of the Anterior Cingulate Cortex in Alzheimer's Disease, Flora Jung, Samaneh Kazemifar, Robert Bartha, and Nagalingam Rajakumar

Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to time-resolved NIRS, Matthew Kewin, Ajay Rajaram, Daniel Milej, Androu Abdalmalak, Laura Morrison, Mamadou Diop, and Keith St Lawrence

Development of a stand-alone DCS system for monitoring absolute cerebral blood flow, Mahro Khalid, Daniel Milej, Ajay Rajaram, Androu Abdalmalak, Laura Morrison, Mamadou Diop, and Keith S.T. Lawrence

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data, Suprateek Kundu, Joshua Lukemire, Yikai Wang, Ying Guo, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem, and Prashanthi Vemuri

A framework for evaluating correspondence between brain images using anatomical fiducials, Jonathan C. Lau, Andrew G. Parrent, John Demarco, Geetika Gupta, Jason Kai, Olivia W. Stanley, Tristan Kuehn, Patrick J. Park, Kayla Ferko, Ali R. Khan, and Terry M. Peters

Predicting Alzheimer’s disease progression using multi-modal deep learning approach, Garam Lee, Kwangsik Nho, Byungkon Kang, Kyung Ah Sohn, Dokyoon Kim, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, and Ronald G. Thomas

Endoscopic Vision Augmentation Using Multiscale Bilateral-Weighted Retinex for Robotic Surgery, Xiongbiao Luo, Hui Qing Zeng, Ying Wan, Xiao Bin Zhang, Yan Ping Du, and Terry M. Peters

Linked MRI signatures of the brain's acute and persistent response to concussion in female varsity rugby players, Kathryn Y. Manning, Alberto Llera, Gregory A. Dekaban, Robert Bartha, Christy Barreira, Arthur Brown, Lisa Fischer, Tatiana Jevremovic, Kevin Blackney, Timothy J. Doherty, Douglas D. Fraser, Jeff Holmes, Christian F. Beckmann, and Ravi S. Menon

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Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) in rats at 9.4 Tesla, Patrick McCunn, Kyle M. Gilbert, Peter Zeman, Alex X. Li, Michael J. Strong, Ali R. Khan, and Robert Bartha

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Does the Neurological Examination Correlate with Patient-Perceived Outcomes in Degenerative Cervical Myelopathy?, Stuart M.K. McGregor, Sarah A. Detombe, Sandy Goncalves, Patricia Doyle-Pettypiece, Robert Bartha, and Neil Duggal

The contribution of multiparametric pelvic and whole-body MRI to interpretation of 18F-fluoromethylcholine or 68Ga-HBED-CC PSMA-11 PET/CT in patients with biochemical failure after radical prostatectomy, Ur Metser, Sue Chua, Bao Ho, Shonit Punwani, Edward Johnston, Frederic Pouliot, Noam Tau, Asmaa Hawsawy, Reut Anconina, Glenn Bauman, Rodney J. Hicks, Andrew Weickhardt, Ian D. Davis, Greg Pond, Andrew M. Scott, Nina Tunariu, Harbir Sidhu, and Louise Emmett

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Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein, Alexander J. Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J. Strong, and Kathryn Volkening

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Hypofractionated stereotactic radiotherapy for intracranial meningioma: A systematic review, Eric K. Nguyen, Timothy K. Nguyen, Gabe Boldt, Alexander V. Louie, and Glenn S. Bauman

Ultrasound calibration for unique 2.5D conical images, Hareem Nisar, John Moore, Natasha Alves, Germain Hwang, Terry M. Peters, and Elvis C.S. Chen

Quality of Life Outcomes After Stereotactic Ablative Radiation Therapy (SABR) Versus Standard of Care Treatments in the Oligometastatic Setting: A Secondary Analysis of the SABR-COMET Randomized Trial, Robert Olson, Suresh Senan, Stephen Harrow, Stewart Gaede, Alexander Louie, Cornelis Haasbeek, Liam Mulroy, Michael Lock, George Rodrigues, Brian Yaremko, Devin Schellenberg, Belal Ahmad, Gwendolyn Griffioen, Sashendra Senthi, Anand Swaminath, Neil Kopek, Mitchell Liu, Karen Moore, Suzanne Currie, Glenn Bauman, Andrew Warner, and David Palma

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Detection of active caspase-3 in mouse models of stroke and Alzheimer's disease with a novel dual positron emission tomography/fluorescent tracer [ 68 Ga]Ga-TC3-OGDOTA, Valeriy G. Ostapchenko, Jonatan Snir, Mojmir Suchy, Jue Fan, M. Rebecca Cobb, Blaine A. Chronik, Michael Kovacs, Vania F. Prado, Robert H.E. Hudson, Stephen H. Pasternak, Marco A.M. Prado, and Robert Bartha

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Accelerated 129Xe MRI morphometry of terminal airspace enlargement: Feasibility in volunteers and those with alpha-1 antitrypsin deficiency, Alexei Ouriadov, Fumin Guo, David G McCormack, and Grace Parraga