Incorporating Pathology-Induced Heterogeneities in a Patient-Specific Biomechanical Model of the Lung for Accurate Tumor Motion Estimation.
Document Type
Conference Proceeding
Publication Date
7-1-2019
Journal
Conference Proceedings IEEE Engineering in Medicine and Biology Society
Volume
2019
First Page
6964
Last Page
6967
URL with Digital Object Identifier
10.1109/EMBC.2019.8856707
Abstract
Radiation therapy (RT) is an important component of treatment for lung cancer. However, the accuracy of this method can be affected by the complex respiratory motion/deformation of the target tumor during treatment. To improve the accuracy of RT, patient-specific biomechanical models of the lung have been proposed for estimating the tumor's respiratory motion/deformation. Chronic obstructive pulmonary disease (COPD) has a high incidence among lung cancer patients and is associated with heterogeneous destruction of lung parenchyma. This key heterogeneity element, however, has not been incorporated in lung biomechanical models developed in previous studies. In this work, we have developed a physiologically and patho-physiologically realistic lung biomechanical model that accounts for lung tissue heterogeneity. Four-dimensional computed tomography (4DCT) images were used to build a patient-specific finite element (FE) model of the lung. Image information was used to identify and incorporate inhomogeneities within the model. Mechanical properties of normal and diseased regions in the lung and the transpulmonary pressure driving the respiratory motion were estimated using an optimization algorithm that maximizes the similarity between the actual and simulated tumor and lung image data. Results from this proof of concept study on a lung cancer patient indicated improved accuracy of tumor motion estimation when COPD-induced lung tissue heterogeneities were incorporated in the model.
Citation of this paper:
P. Jafari, D. A. Hoover, B. P. Yaremko, G. Parraga, A. Samani and A. Sadeghi-Naini, "Incorporating Pathology-Induced Heterogeneities in a Patient-Specific Biomechanical Model of the Lung for Accurate Tumor Motion Estimation," 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 2019, pp. 6964-6967.
Notes
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