Research in Medical Biophysics Publications focuses on the application of physics in the human body and those of higher animals while examining topics such as blood flow, orthopedic mechanics, medical imaging and cancer biology. Research is conducted in partnership with clinicians at state-of-the-art facilities located at Western University, London Regional Cancer Program, Lawson Health Research Institute, Robarts Research Institute, and the London Health Sciences Centre.

Visit the Department of Medical Biophysics website for additional information.

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Submissions from 2019

Preface, Dinggang Shen, Tianming Liu, Terry M. Peters, Lawrence H. Staib, Caroline Essert, Sean Zhou, Pew Thian Yap, and Ali Khan

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Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: Protocol for a single-centre, randomized, double-blind, placebo-controlled trial, C. R.A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins, M. Jog, and S. H. Pasternak

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White matter integrity is associated with gait impairment and falls in mild cognitive impairment. Results from the gait and brain study, Jonatan A. Snir, Robert Bartha, and Manuel Montero-Odasso

The utility of multivariate outlier detection techniques for data quality evaluation in large studies: An application within the ONDRI project, Kelly M. Sunderland, Derek Beaton, Julia Fraser, Donna Kwan, Paula M. McLaughlin, Manuel Montero-Odasso, Alicia J. Peltsch, Frederico Pieruccini-Faria, Demetrios J. Sahlas, Richard H. Swartz, Robert Bartha, Sandra E. Black, Michael Borrie, Dale Corbett, Elizabeth Finger, Morris Freedman, Barry Greenberg, David A. Grimes, Robert A. Hegele, Chris Hudson, Anthony E. Lang, Mario Masellis, William E. McIlroy, David G. Munoz, Douglas P. Munoz, J. B. Orange, Michael J. Strong, Sean Symons, Maria Carmela Tartaglia, Angela Troyer, Lorne Zinman, and Stephen C. Strother

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Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab, Sarah Svenningsen, Ehsan Ahmed Haider, Rachel L Eddy, Grace Parraga, and Parameswaran Nair

CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma, Sarah Svenningsen, Ehsan Haider, Colm Boylan, Manali Mukherjee, Rachel L Eddy, Dante P I Capaldi, Grace Parraga, and Parameswaran Nair

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Ventricular volume expansion in presymptomatic genetic frontotemporal dementia, Tamara P. Tavares, Derek G.V. Mitchell, Kristy Coleman, Christen Shoesmith, Robert Bartha, David M. Cash, Katrina M. Moore, John Van Swieten, Barbara Borroni, Daniela Galimberti, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Stefano Cappa, Robert Laforce, Alexandre De Mendonça, Sandro Sorbi, Garrick Wallstrom, Mario Masellis, Jonathan D. Rohrer, and Elizabeth C. Finger

How Accurately Does Transesophageal Echocardiography Identify the Mitral Valve?, Claire Vannelli, Wenyao Xia, John Moore, and Terry Peters

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics, Yogatheesan Varatharajah, Vijay K. Ramanan, Ravishankar Iyer, Prashanthi Vemuri, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, and Ronald G. Thomas

Determining blood flow direction from short neurovascular surgical microscope videos, Reid Vassallo, Adam Rankin, Stephen P. Lownie, Hitoshi Fukuda, Hidetoshi Kasuya, Benjamin W.Y. Lo, Terry Peters, and Yiming Xiao

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Chronic Obstructive Pulmonary Disease: Thoracic CT Texture Analysis and Machine Learning to Predict Pulmonary Ventilation, Andrew Westcott, Dante P I Capaldi, David G McCormack, Aaron D Ward, Aaron Fenster, and Grace Parraga

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Hyperpolarized 3He MRI Ventilatory Apparent Diffusion Coefficient of Alpha-1 Antitrypsin, Andrew Westcott, Dante P I Capaldi, Alexei Ouriadov, David G McCormack, and Grace Parraga

Rapid single-breath hyperpolarized noble gas MRI-based biomarkers of airspace enlargement, Andrew Westcott, Fumin Guo, Grace Parraga, and Alexei Ouriadov

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications, Andrew Westcott, David G McCormack, Grace Parraga, and Alexei Ouriadov

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Methodological consensus on clinical proton MRS of the brain: Review and recommendations, Martin Wilson, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Alberto Bizzi, Patrick J. Bolan, Kevin M. Brindle, In Young Choi, Cristina Cudalbu, Ulrike Dydak, Uzay E. Emir, Ramon G. Gonzalez, Stephan Gruber, Rolf Gruetter, Rakesh K. Gupta, Arend Heerschap, Anke Henning, Hoby P. Hetherington, Petra S. Huppi, Ralph E. Hurd, Kejal Kantarci, Risto A. Kauppinen, Dennis W.J. Klomp, Roland Kreis, Marijn J. Kruiskamp, Martin O. Leach, Alexander P. Lin, Peter R. Luijten, Małgorzata Marjańska, Andrew A. Maudsley, Dieter J. Meyerhoff, and Carolyn E. Mountford

An accurate registration of the BigBrain dataset with the MNI PD25 and ICBM152 atlases, Yiming Xiao, Jonathan C. Lau, Taylor Anderson, Jordan DeKraker, D. Louis Collins, Terry Peters, and Ali R. Khan

A Global Optimization Method for Specular Highlight Removal from a Single Image, Wenyao Xia, Elvis C.S. Chen, Stephen E. Pautler, and Terry M. Peters

Automatic Paraspinal Muscle Segmentation in Patients with Lumbar Pathology Using Deep Convolutional Neural Network, Wenyao Xia, Maryse Fortin, Joshua Ahn, Hassan Rivaz, Michele C. Battié, Terry M. Peters, and Yiming Xiao

MRI and CT lung biomarkers: Towards an in vivo understanding of lung biomechanics, Heather M Young, Rachel L Eddy, and Grace Parraga

Layer-based visualization and biomedical information exploration of multi-channel large histological data, Qi Zhang, Terry Peters, and Aaron Fenster

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk, Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C.Y. Kwok, Vincent C.T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek M. Mesulam, and William Potter

Submissions from 2018

Design and evaluation of a diffusion MRI fibre phantom using 3D printing, Serene O. Abu-Sardanah, Uzair Hussain, John Moore, Corey Baron, Terry Peters, and Ali R. Khan

On the Potential Role of MRI Biomarkers of COPD to Guide Bronchoscopic Lung Volume Reduction, Colin J Adams, Dante P I Capaldi, Robert Di Cesare, David G McCormack, and Grace Parraga

Quantitative Analysis of Needle Navigation under Ultrasound Guidance in s Simulated Central Venous Line Procedure, Golafsoun Ameri, Daniel Bainbridge, Terry M. Peters, and Elvis C.S. Chen

Mixed reality ultrasound guidance system: a case study in system development and a cautionary tale, Golafsoun Ameri, John S.H. Baxter, Daniel Bainbridge, Terry M. Peters, and Elvis C.S. Chen