Research in Medical Biophysics Publications focuses on the application of physics in the human body and those of higher animals while examining topics such as blood flow, orthopedic mechanics, medical imaging and cancer biology. Research is conducted in partnership with clinicians at state-of-the-art facilities located at Western University, London Regional Cancer Program, Lawson Health Research Institute, Robarts Research Institute, and the London Health Sciences Centre.

Visit the Department of Medical Biophysics website for additional information.

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Submissions from 2020

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FEV1 and MRI Ventilation Defect Reversibility in Asthma and COPD, Hana Serajeddini, Rachel L Eddy, Christopher Licskai, David G McCormack, and Grace Parraga

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology, Xinpeng Shen, Sisi Ma, Prashanthi Vemuri, Gyorgy Simon, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, Andrew J. Saykin, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, and Ronald G. Thomas

Case – 18F-DCFPyL-positron emission tomography/computed tomography (PET/CT) time of imaging, Golmehr Sistani, Ur Metser, Glenn S. Bauman, David T. Laidley, Stephen E. Pautler, and Katherine A. Zukotynski

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease, Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Uberti, Michael W. Weiner, Paul Aisen, Ronald Petersen, Jack R. Clifford, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, and Tom Montine

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Holistic multitask regression network for multiapplication shape regression segmentation, Clara M. Tam, Dong Zhang, Bo Chen, Terry Peters, and Shuo Li

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Optimum imaging strategies for advanced prostate cancer: ASCO guideline, Edouard J. Trabulsi, R. Bryan Rumble, Hossein Jadvar, Thomas Hope, Martin Pomper, Baris Turkbey, Andrew B. Rosenkrantz, Sadhna Verma, Daniel J. Margolis, Adam Froemming, Aytekin Oto, Andrei Purysko, Matthew I. Milowsky, Heinz Peter Schlemmer, Matthias Eiber, Michael J. Morris, Peter L. Choyke, Anwar Padhani, Jorge Oldan, Stefano Fanti, Suneil Jain, Peter A. Pinto, Kirk A. Keegan, Christopher R. Porter, Jonathan A. Coleman, Glenn S. Bauman, Ashesh B. Jani, Jeffrey M. Kamradt, Westley Sholes, and H. Alberto Vargas

Re: Joaquin Mateo, Karim Fizazi, Silke Gillessen, et al. Managing Nonmetastatic Castration-resistant Prostate Cancer. Eur Urol 2019:75:285–93, Finn Edler von Eyben and Glenn Bauman

Re: Silke Gillessen, Gerhardt Attard, Tomasz M. Beer, et al. Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. Eur Urol. 2020;77: 508–47 https://doi.org/10.1016/j.eururo.2020.01.012, Finn Edler von Eyben, Glenn Bauman, Cigdem Soydal, and Giovanni Paganelli

Optimizing psma radioligand therapy for patients with metastatic castration-resistant prostate cancer. A systematic review and meta-analysis, Finn Edler von Eyben, Glenn Bauman, Rie von Eyben, Kambiz Rahbar, Cigdem Soydal, Alexander R. Haug, Irene Virgolini, Harshad Kulkarni, Richard Baum, and Giovanni Paganelli

The Effects of Positioning on the Volume/Location of the Internal Jugular Vein Using 2-Dimensional Tracked Ultrasound, Wanyu Wang, Xinyang Liao, Elvis C.S. Chen, John Moore, John S.H. Baxter, Terry M. Peters, and Daniel Bainbridge

Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study, Dickson Wong, Samir Atiya, Jennifer Fogarty, Manuel Montero-Odasso, Stephen H. Pasternak, Chris Brymer, Michael J. Borrie, and Robert Bartha

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Arthur W. Toga, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, and Matthew Bernstein

Submissions from 2019

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The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging, Mohammed Albatany, Susan Meakin, and Robert Bartha

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Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms, Mohammed Albatany, Valeriy G. Ostapchenko, Susan Meakin, and Robert Bartha

Texture-based prostate cancer classification on MRI: How does inter-class size mismatch affect measured system performance?, R. Alfano, D. Soetemans, G. S. Bauman, M. Gaed, M. Moussa, J. A. Gomez, J. L. Chin, S. Pautler, and A. D. Ward

Erratum to ‘Quantitative Analysis of Needle Navigation under Ultrasound Guidance in a Simulated Central Venous Line Procedure'[Ultrasound Med Biol 44 (2018) 1891-1900](S030156291830187X)(10.1016/j.ultrasmedbio.2018.05.004), Golafsoun Ameri, Daniel Bainbridge, Terry M. Peters, and Elvis C.S. Chen

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Development and Evaluation of an Augmented Reality Ultrasound Guidance System for Spinal Anesthesia: Preliminary Results, Golafsoun Ameri, Adam Rankin, John S.H. Baxter, John Moore, Sugantha Ganapathy, Terry M. Peters, and Elvis C.S. Chen

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Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease, Sonia S Anand, Jack V Tu, Dipika Desai, Phillip Awadalla, Paula Robson, Sébastien Jacquemont, Trevor Dummer, Nhu Le, Louise Parker, Paul Poirier, Koon Teo, Scott A Lear, Salim Yusuf, Jean-Claude Tardif, Francois Marcotte, David Busseuil, Jean-Pierre Després, Sandra E Black, Anish Kirpalani, Grace Parraga, Michael D Noseworthy, Alexander Dick, Jonathan Leipsic, David Kelton, Jennifer Vena, Melissa Thomas, Karleen M Schulze, Eric Larose, Alan R Moody, Eric E Smith, and Matthias G Friedrich

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Dynamic light scattering optical coherence tomography to probe motion of subcellular scatterers., Nico J J Arezza, Marjan Razani, and Michael C Kolios

Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury, Gemma Bale, Ajay Rajaram, Matthew Kewin, Laura Morrison, Alan Bainbridge, Linshan Liu, Udunna Anazodo, Mamadou Diop, Keith St Lawrence, and Ilias Tachtsidis

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Mousebytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment, Flavio H. Beraldo, Daniel Palmer, Sara Memar, David I. Wasserman, Wai Jane V. Lee, Shuai Liang, Samantha D. Creighton, Benjamin Kolisnyk, Matthew F. Cowan, Justin Mels, Talal S. Masood, Chris Fodor, Mohammed A. Al-Onaizi, Robert Bartha, Tom Gee, Lisa M. Saksida, Timothy J. Bussey, Stephen S. Strother, Vania F. Prado, Boyer D. Winters, and Marco A.M. Prado

A dynamic neonatal heart phantom for ultrafast color Doppler echocardiography evaluation, Nora Boone, James C. Lacefield, John Moore, Olivia Ginty, Xin Yue Wang, Tamie L. Poepping, Daniel Bainbridge, and Terry Peters

A dynamic mitral valve simulator for surgical training and patient specific preoperative planning, Nora Boone, John Moore, Olivia Ginty, Daniel Bainbridge, Mehdi Eskandari, and Terry Peters

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Characterization of clinical human prostate cancer lesions using 3.0-T sodium MRI registered to Gleason-graded whole-mount histopathology, Nolan C. Broeke, Justin Peterson, Joseph Lee, Peter R. Martin, Adam Farag, Jose A. Gomez, Madeleine Moussa, Mena Gaed, Joseph Chin, Stephen E. Pautler, Aaron Ward, Glenn Bauman, Robert Bartha, and Timothy J. Scholl

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A Phase I/II Trial of Fairly Brief Androgen Suppression and Stereotactic Radiation Therapy for High-Risk Prostate Cancer (FASTR-2): Preliminary Results and Toxicity Analysis, Laura Callan, Glenn Bauman, Jeff Chen, Michael Lock, Tracy Sexton, David D'Souza, and George Rodrigues