Research in Medical Biophysics Publications focuses on the application of physics in the human body and those of higher animals while examining topics such as blood flow, orthopedic mechanics, medical imaging and cancer biology. Research is conducted in partnership with clinicians at state-of-the-art facilities located at Western University, London Regional Cancer Program, Lawson Health Research Institute, Robarts Research Institute, and the London Health Sciences Centre.

Visit the Department of Medical Biophysics website for additional information.

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Submissions from 2021

Four distinct trajectories of tau deposition identified in Alzheimer’s disease, Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, and Matthew Bernstein

Effect of Memantine Treatment and Combination with Vitamin D Supplementation on Body Composition in the APP/PS1 Mouse Model of Alzheimer's Disease following Chronic Vitamin D Deficiency, Dickson Wong, Dana N. Broberg, Jagroop Doad, Joseph U. Umoh, Miranda Bellyou, Chris J.D. Norley, David W. Holdsworth, Manuel Montero-Odasso, Olivier Beauchet, Cedric Annweiler, Robert Bartha, and Benedict Albensi

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Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes, Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha, Mark Daley, Haojie Mao, Vania Prado, Marco A.M. Prado, Lisa Saksida, Tim Bussey, and Arthur Brown

Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [18F]DCFPyL-PET: comparison to [18F]fluorocholine-PET, Dae Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant, and Ting Yim Lee

Prostate-specific membrane antigen targeted PET/CT for recurrent prostate cancer: a clinician’s guide, Sympascho Young, Wei Liu, Katherine Zukotynski, and Glenn Bauman

Submissions from 2020

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Using fMRI to investigate the potential cause of inverse oxygenation reported in fNIRS studies of motor imagery, Androu Abdalmalak, Daniel Milej, David J. Cohen, Udunna Anazodo, Tracy Ssali, Mamadou Diop, Adrian M. Owen, and Keith St. Lawrence

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Assessing Time-Resolved fNIRS for Brain-Computer Interface Applications of Mental Communication, Androu Abdalmalak, Daniel Milej, Lawrence C.M. Yip, Ali R. Khan, Mamadou Diop, Adrian M. Owen, and Keith St. Lawrence

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Assessing Time-Resolved fNIRS for Brain-Computer Interface Applications of Mental Communication, Androu Abdalmalak, Daniel Milej, Lawrence C.M. Yip, Ali R. Khan, Mamadou Diop, Adrian M. Owen, and Keith St. Lawrence

Evaluating texture-based prostate cancer classification on multi-parametric magnetic resonance imaging and prostate specific membrane antigen positron emission tomography, R. Alfano, G. S. Bauman, J. Thiessen, I. Rachinsky, W. Pavlosky, J. Butler, M. Gaed, M. Moussa, J. A. Gomez, J. L. Chin, S. Pautler, and A. D. Ward

Histologic validation of auto-contoured dominant intraprostatic lesions on [18F] DCFPyL PSMA-PET imaging, Ryan Alfano, Glenn S. Bauman, Wei Liu, Jonathan D. Thiessen, Irina Rachinsky, William Pavlosky, John Butler, Mena Gaed, Madeleine Moussa, Jose A. Gomez, Joseph L. Chin, Stephen Pautler, and Aaron D. Ward

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Miniature C-arm simulator using wireless accelerometer based tracking, Daniel R. Allen, John Moore, Abigayel Joschko, Collin Clarke, Terry M. Peters, and Elvis C.S. Chen

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Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging-Detected Vascular Brain Injury, Sonia S Anand, Matthias G Friedrich, Dipika Desai, Karleen M Schulze, Philip Awadalla, David Busseuil, Trevor J B Dummer, Sébastien Jacquemont, Alexander Dick, David Kelton, Anish Kirpalani, Scott A Lear, Jonathan Leipsic, Michael D Noseworthy, Louise Parker, Grace Parraga, Paul Poirier, Paula Robson, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Alan R Moody, Sandra E Black, and Eric E Smith

American Society for Radiation Oncology Editorial: Rapidly Evolving Technologies Related to Imaging Strategies for Advanced Prostate Cancer, Glenn S. Bauman and Ashesh B. Jani

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Patient-specific, dynamic models of hypoplastic left heart syndrome tricuspid valves for simulation and planning, Nora Boone, Hannah H. Nam, John Moore, Patrick Carnahan, Olivia Ginty, Christian Herz, Andras Lasso, Matthew A. Jolley, Elvis C.S. Chen, and Terry Peters

Hip capsular strain varies between ligaments dependent on both hip position- and applied rotational force, Timothy A. Burkhart, Pardis Baha, Alexandra Blokker, Ivailo Petrov, David W. Holdsworth, Maria Drangova, Alan Getgood, and Ryan M. Degen

Multi-view 3D echocardiography volume compounding for mitral valve procedure planning, Patrick Carnahan, John Moore, Daniel Bainbridge, Elvis C.S. Chen, and Terry M. Peters

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Applications of VR medical image visualization to chordal length measurements for cardiac procedures, Patrick Carnahan, John Moore, Daniel Bainbridge, Gavin Wheeler, Shujie Deng, Kuberan Pushparajah, Elvis C.S. Chen, John M. Simpson, and Terry M. Peters

The Singularity is Near(ish): Emerging Applications of Artificial Intelligence in Prostate Cancer Management, Joseph Chin, Glenn Bauman, Nicholas Power, and Aaron Ward

Re: Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review, Joseph L. Chin and Glenn S. Bauman

A Novel Salvage Option for Local Failure in Prostate Cancer, Reirradiation Using External Beam or Stereotactic Radiation Therapy: Systematic Review and Meta-Analysis, Mark T. Corkum, Lucas C. Mendez, Joseph Chin, David D'Souza, R. Gabriel Boldt, and Glenn S. Bauman

Is prostate brachytherapy a dying art? Trends and variation in the definitive management of prostate cancer in Ontario, Canada, Mark T. Corkum, Gerard Morton, Alexander V. Louie, Glenn S. Bauman, Lucas C. Mendez, Joseph Chin, David P. D'Souza, Robert E. Dinniwell, Vikram M. Velker, Refik Saskin, Andrew Warner, and George B. Rodrigues

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Pulmonary xenon-129 MRI: New opportunities to unravel enigmas in respiratory medicine, Rachel L Eddy and Grace Parraga

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Is Computed Tomography Airway Count Related to Asthma Severity and Airway Structure and Function?, Rachel L Eddy, Sarah Svenningsen, Miranda Kirby, Danielle Knipping, David G McCormack, Christopher Licskai, Parameswaran Nair, and Grace Parraga

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, and Nick Fox

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration, Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, Michael Weiner, Paul Aisen, Gerald Novak, Robert C. Green, Tom Montine, Ronald Petersen, Anthony Gamst, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Laurel Beckett, Danielle Harvey, John Kornak, Clifford R. Jack, Anders Dale, Matthew Bernstein, and Joel Felmlee