Development of a stand-alone DCS system for monitoring absolute cerebral blood flow

Authors

Mahro Khalid, Lawson Health Research Institute
Daniel Milej, Lawson Health Research Institute
Ajay Rajaram, Lawson Health Research Institute
Androu Abdalmalak, Lawson Health Research Institute
Laura Morrison, Lawson Health Research Institute
Mamadou Diop, Lawson Health Research Institute
Keith S.T. Lawrence, Lawson Health Research Institute

Document Type

Article

Publication Date

9-1-2019

Journal

Biomedical Optics Express

First Page

4607

Last Page

4620

URL with Digital Object Identifier

10.1364/BOE.10.004607

Abstract

© 2019 Optical Society of America. Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique for monitoring cerebral blood flow (CBF). This work presents a stand-alone DCS system capable of monitoring absolute CBF by incorporating a quantitative dynamic contrast-enhanced (DCE) technique. Multi-distance data were acquired to measure the tissue optical properties and to perform DCE experiments. Feasibility of the technique was assessed in piglets in which the optical properties were measured independently by time-resolved near-infrared spectroscopy. A strong linear correlation was observed between CBF values derived using the two sets of optical properties, demonstrating that this hybrid DCS approach can provide real-time monitoring of absolute CBF.