Research in Medical Biophysics Publications focuses on the application of physics in the human body and those of higher animals while examining topics such as blood flow, orthopedic mechanics, medical imaging and cancer biology. Research is conducted in partnership with clinicians at state-of-the-art facilities located at Western University, London Regional Cancer Program, Lawson Health Research Institute, Robarts Research Institute, and the London Health Sciences Centre.

Visit the Department of Medical Biophysics website for additional information.

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Submissions from 2021

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Rapid microscopic fractional anisotropy imaging via an optimized linear regression formulation., N J J Arezza, D H Y Tse, and C A Baron

Disease-related cortical thinning in presymptomatic granulin mutation carriers, Sergi Borrego-Écija, Roser Sala-Llonch, John van Swieten, Barbara Borroni, Fermín Moreno, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, Robert Laforce, James B. Rowe, Elizabeth Finger, Rik Vandenberghe, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Matthis Synofzik, Simon Ducharme, Johannes Levin, Adrian Danek, Alex Gerhard, Markus Otto, Chris Butler, Giovanni Frisoni, Sandro Sorbi, Carolin Heller, Martina Bocchetta, David M. Cash, Rhian S. Convery, Katrina M. Moore, Jonathan D. Rohrer, and Raquel Sanchez-Valle

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The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review, Nick W. Bray, Frederico Pieruccini-Faria, Robert Bartha, Timothy J. Doherty, Lindsay S. Nagamatsu, and Manuel Montero-Odasso

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study, Shi Dong Chen, Jia Ying Lu, Hong Qi Li, Yu Xiang Yang, Jie Hui Jiang, Mei Cui, Chuan Tao Zuo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, and Eliezer Masliah

Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization, Yeonwoo Chung, Hyunju Lee, Michael W. Weiner, Paul Aisen, Ronald Petersen, Cliford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, and Tamie Sather

Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease, Sandhitsu R. Das, Xueying Lyu, Michael Tran Duong, Long Xie, Lauren McCollum, Robin de Flores, Michael DiCalogero, David J. Irwin, Bradford C. Dickerson, Ilya M. Nasrallah, Paul A. Yushkevich, David A. Wolk, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, and Gus Jiminez

Bilingualism in Parkinson’s disease: Relationship to cognition and quality of life, Keera N. Fishman, Angela C. Roberts, J. B. Orange, Kelly M. Sunderland, Connie Marras, Brian Tan, Thomas Steeves, Donna Kwan, Anthony E. Lang, David Grimes, Brian Levine, Mario Masellis, Malcolm A. Binns, Mandar Jog, Stephen C. Strother, Paula M. McLaughlin, Angela K. Troyer, Robert Bartha, Sandra E. Black, Michael Borrie, Dale Corbett, Elizabeth Finger, Morris Freedman, Barry Greenberg, Robert A. Hegele, Chris Hudson, William E. McIlroy, Manuel Montero-Odasso, David G. Munoz, Douglas P. Munoz, Michael J. Strong, and Richard H. Swartz

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease, William T. Hu, Tugba Ozturk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Richard J. Perrin, Leslie M. Shaw, Zaven Kachaturian, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Eliezer Masliah, Donna Masterman, Ozioma Okonkwo, Laurie Ryan, Nina Silverberg, and Adam Fleisher

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nnResting state fMRI scanner instabilities revealed by longitud inal phantom scans in a multi-center study, Aras Kayvanrad, Stephen R. Arnott, Nathan Churchill, Stefanie Hassel, Aditi Chemparathy, Fan Dong, Mojdeh Zamyadi, Tom Gee, Robert Bartha, Sandra E. Black, Jane M. Lawrence-Dewar, Christopher J.M. Scott, Sean Symons, Andrew D. Davis, Geoffrey B. Hall, Jacqueline Harris, Nancy J. Lobaugh, Glenda MacQueen, Cindy Woo, and Stephen Strother

Magnetic Resonance Imaging Sequence Identification Using a Metadata Learning Approach, Shuai Liang, Derek Beaton, Stephen R. Arnott, Tom Gee, Mojdeh Zamyadi, Robert Bartha, Sean Symons, Glenda M. MacQueen, Stefanie Hassel, Jason P. Lerch, Evdokia Anagnostou, Raymond W. Lam, Benicio N. Frey, Roumen Milev, Daniel J. Müller, Sidney H. Kennedy, Christopher J.M. Scott, and Stephen C. Strother

Utilization of Salvage and Systemic Therapies for Recurrent Prostate Cancer as a Result of 18F-DCFPyL PET/CT Restaging, Wei Liu, Katherine Zukotynski, Louise Emmett, Hans T. Chung, Peter Chung, Robert Wolfson, Irina Rachinsky, Anil Kapoor, Ur Metser, Andrew Loblaw, Gerard Morton, Tracy Sexton, Michael Lock, Joelle Helou, Alejandro Berlin, Colm Boylan, Susan Archer, Gregory R. Pond, and Glenn Bauman

Ensembling Imbalanced-Spatial-Structured Support Vector Machine, Xin Liu, Grace Y. Yi, Glenn Bauman, and Wenqing He

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Neurite orientation dispersion and density imaging in a rodent model of acute mild traumatic brain injury, Patrick McCunn, Xiaoyun Xu, Alexander Moszczynski, Alex Li, Arthur Brown, and Robert Bartha

Concussion acutely decreases plasma glycerophospholipids in adolescent male athletes, Michael R. Miller, Michael Robinson, Robert Bartha, Tanya Charyk Stewart, Lisa Fischer, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, and Douglas D. Fraser

Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics, Michael R. Miller, Michael Robinson, Lisa Fischer, Alicia DiBattista, Maitray A. Patel, Mark Daley, Robert Bartha, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, Eleftherios P. Diamandis, Ioannis Prassas, and Douglas D. Fraser

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease, Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCArli, and Bret Borowski

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Improved Segmentation of the Intracranial and Ventricular Volumes in Populations with Cerebrovascular Lesions and Atrophy Using 3D CNNs, Emmanuel E. Ntiri, Melissa F. Holmes, Parisa M. Forooshani, Joel Ramirez, Fuqiang Gao, Miracle Ozzoude, Sabrina Adamo, Christopher J.M. Scott, Dar Dowlatshahi, Jane M. Lawrence-Dewar, Donna Kwan, Anthony E. Lang, Sean Symons, Robert Bartha, Stephen Strother, Jean Claude Tardif, Mario Masellis, Richard H. Swartz, Alan Moody, Sandra E. Black, and Maged Goubran

Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations, Gülin Öz, Dinesh K. Deelchand, Jannie P. Wijnen, Vladimír Mlynárik, Lijing Xin, Ralf Mekle, Ralph Noeske, Tom W.J. Scheenen, Ivan Tkáč, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Adam Berrington, Vincent Boer, Christina Cudalbu, Uzay E. Emir, Thomas Ernst, Ariane Fillmer, Arend Heerschap, Pierre Gilles Henry, Ralph E. Hurd, James M. Joers, Christoph Juchem, Hermien E. Kan, Dennis W.J. Klomp, Roland Kreis, Karl Landheer, Silvia Mangia, Małgorzata Marjańska, Jamie Near, Eva M. Ratai, and Itamar Ronen

Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma, Qi Qi, Matthew S. Fox, Heeseung Lim, Robert Bartha, Timothy J. Scholl, Lisa Hoffman, Ting Yim Lee, and Jonathan D. Thiessen

MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease, Joel Ramirez, Melissa F. Holmes, Courtney Berezuk, Donna Kwan, Brian Tan, Derek Beaton, Christopher J.M. Scott, Miracle Ozzoude, Fuqiang Gao, Di Yu, Walter Swardfager, Jane Lawrence-Dewar, Dar Dowlatshahi, Gustavo Saposnik, Mark I. Boulos, Brian J. Murray, Sean Symons, Robert Bartha, Sandra E. Black, Richard H. Swartz, Michael Strong, Peter Kleinstiver, Natalie Rashkovan, Susan Bronskill, Michael Borrie, Elizabeth Finger, Corinne Fischer, Andrew Frank, Morris Freedman, Sanjeev Kumar, Stephen Pasternak, and Bruce Pollock

Predicting Cognitive Impairment in Cerebrovascular Disease Using Spoken Discourse Production, Angela Roberts, Katharine Aveni, Shalane Basque, Joseph B. Orange, Paula McLaughlin, Joel Ramirez, Angela K. Troyer, Stephanie Gutierrez, Angie Chen, Robert Bartha, Malcolm A. Binns, Sandra E. Black, Leanne K. Casaubon, Dar Dowlatshahi, Ayman Hassan, Donna Kwan, Brian Levine, Jennifer Mandzia, Demetrios J. Sahlas, Christopher J.M. Scott, Stephen Strother, Kelly M. Sunderland, Sean Symons, and Richard Swartz

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status, Xue Ning Shen, Yu Yuan Huang, Shi Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Maria Carrillo, William Potter, Lisa Barnes, Marie Bernard, Hector González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, and Ozioma Okonkwo

A multiobserver study investigating the effectiveness of prostatic multiparametric magnetic resonance imaging to dose escalate corresponding histologic lesions using high-dose-rate brachytherapy, Christopher W. Smith, Douglas Hoover, Kathleen Surry, David D'Souza, Derek W. Cool, Zahra Kassam, Matthew Bastian-Jordan, Jose A. Gomez, Madeleine Moussa, Joseph Chin, Stephen Pautler, Glenn S. Bauman, and Aaron D. Ward

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Multisite Comparison of MRI Defacing Software Across Multiple Cohorts, Athena E. Theyers, Mojdeh Zamyadi, Mark O'Reilly, Robert Bartha, Sean Symons, Glenda M. MacQueen, Stefanie Hassel, Jason P. Lerch, Evdokia Anagnostou, Raymond W. Lam, Benicio N. Frey, Roumen Milev, Daniel J. Müller, Sidney H. Kennedy, Christopher J.M. Scott, Stephen C. Strother, and Stephen R. Arnott

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease (Nature Communications, (2020), 11, 1, (2612), 10.1038/s41467-020-15701-2), Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Michael Donohue, Matthew Bernstein, Nick Fox, and Paul Thompson