Microbiology & Immunology Theses and Dissertations
This collection contains theses and dissertations from the Department of Microbiology & Immunology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2018
Effect of Bacterial Superantigens on the Magnitude and Breadth of Influenza-Specific CD8+ T Cell Responses, Courtney Meilleur
Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses, Seyed Arad Moghadasi
The Role of the HIV-1 Accessory Proteins Nef and Vpu in Subverting Host Cellular Immunity, Emily N. Pawlak
The Role Of Spi-B And Pu.1 Transcription Factors In B Cell Development And In Suppression Of Leukemogenesis, Carolina Reyes Batista
The Role of PU.1 in Lipid Metabolism and Cell Cycle Regulation in Myeloid Progenitor Cells, Jess Rhee
Elucidation of the Signaling Pathway of MERTK, Kyle Taruc
The Surreptitious Survival of The Emerging Pathogen Staphylococcus lugdunensis in Macrophages Enhances S. aureus Infection, David Watson
Contribution of Enterococcus faecalis to urinary tract infection, Samantha Ann Whiteside
Elucidating the Importance of HopE and its Potential Lewis Glycosylation in Helicobacter pylori, Keertika Yogendirarajah
Theses/Dissertations from 2017
Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus, Heba Alnaseri
Evaluating Evolving Leukocyte Populations In Peripheral Blood Circulation Post-Concussion In A Human Longitudinal Analysis Of Female Athletes, Kevin A. Blackney
Carbohydrates and Fungal Toxin Exposure Influence the Vaginal Microbiota, Metabolome, and Reproductive Health of Women, Stephanie L. Collins
Characterizing Ferroportin Trafficking in Macrophages During Phagocytosis, Tayler J. Farrell
Investigating Adenovirus E1A as an RNA Polymerase II C-Terminal Domain Mimic and its Role in Transcription Activation, Kristianne JC Galpin
Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus, Jamie N. Halucha
Characterizing the Interaction Between Human Adenovirus E1A and STING, Jessica Hill
Examination of BCAA Transport and Synthesis in Staphylococcus aureus, Julienne Kaiser
Immune responses to homocitrulline- and citrulline-containing peptides in rheumatoid arthritis, Patrick Lac
Rapid Regulatory and Effector Immune Responses in Toxic Shock Syndrome, Peter Anthony Szabo
Superantigen responsive T cells are required for nasopharyngeal infection by Streptococcus pyogenes, Joseph J. Zeppa
Characterizing the Interaction Between Human Adenovirus E1A and the Transcriptional Repressor BS69, Ali Zhang
Theses/Dissertations from 2016
Structural and functional studies of the heptose modifying enzymes that play a role in Campylobacter jejuni virulence., Heba Soliman Barnawi
Evolutionary History and Biological Regulation of CD93, Jack W D Blackburn
Iron acquisition strategies employed by Staphylococcus lugdunensis, Jeremy R. Brozyna
Evaluation of MERTK evolution and efferocytosis signalling, Amanda L. Evans
Protective Benefits of Hydrogen Sulfide Treatment During Renal Transplantation, Ian Lobb
Utilizing untargeted metabolomics to characterize microbial communities and identify biomarkers of an unhealthy state, Amy McMillan
Mitigation of Pesticide Toxicity by Food-Grade Lactobacilli, Mark E. Trinder
Characterization of microbial communities in the mammary glands and the influence of this microbiota on health and disease, Camilla Urbaniak
Theses/Dissertations from 2015
Recombinase-based in vivo expression technology identifies a Streptococcus pyogenes bacteriocin important for niche adaptation in the nasopharynx, Brent D. Armstrong
Clinical and Mechanistic Insights into Novel Probiotic Functions and Formulations, Jordan Bisanz
Characterizing the C-terminal Region of Human Adenovirus E1A: An Undiscovered Country, Michael J. Cohen
Genomic analyses of Paenibacillus polymyxa CR1, a bacterium with potential applications in biomass degradation and biofuel production, Alexander W. Eastman
Supplementation With Hydrogen Sulfide Helps Mitigate The Effects Of Ischemia Reperfusion Injury In A Model Of Donation After Cardiac Death Renal Transplantation, Jaskirandeep Kaur Grewal
Kidney Injury Molecule-1 Signalling in Ischemic Acute Kidney Injury and Phagocytosis, Ola Z. Ismail
Characterization of the AtsR/AtsT global regulatory pathway in Burkholderia ceocepacia, Maryam Khodai-Kalaki
Characterization of fatty acid resistant Staphylococcus aureus mutants containing SNPs in cvfA, Melissa N. Loyzer
The Role of Streptococcus salivarius as a Modulator of Homeostasis in the Oral Cavity, Kyle W. MacDonald
Granulocyte colony-stimulating factor: Its role in gut-homing macrophage generation and colitis, and production by probiotics, Shahab Meshkibaf
Development of a Novel Humanized Single Chain Antibody-Streptococcal Superantigen-Derived Immunotherapy Targeting the 5T4 Oncofetal Antigen, Kelcey G. Patterson
Elucidating the Role of HDAC8 in Anthrax Lethal Toxin-Induced Pyroptosis and Cytokine Gene Silencing in Macrophages, Chantelle M. Reid
Overcoming Innate and Acquired Therapy Resistance by Targeting DNA Repair in Human Cancer Cells, Mateusz Rytelewski
Investigating The Regulation Of A Fatty Acid Efflux Pump In Methicillin Resistant Staphylococcus Aureus, James ET Schneider
Iron Acquisition Mechanisms and Their Role in Staphylococcus aureus Survival and Virulence, Jessica R. Sheldon
Streptococcus pyogenes Superantigens: Studies Into Host Specificity and Functional Redundancy, Adrienne T. Wakabayashi
Molecular Characterization of HERC5: A Novel Multifunctional Antiviral Protein, Matthew W. Woods
Theses/Dissertations from 2014
Analysis of Invariant Natural Killer T Cells in Intra-Abdominal Sepsis, Ram Venkatesh Anantha
Elucidating the Signalling Pathway of Mer Tyrosine Kinase Receptor in Efferocytosis, Ekenedelichukwu Azu
Cell Biology of the Entry of Bdellovibrio and Like Organisms, Ryan M. Chanyi
siRNA Targeting of Thymidylate Synthase, Thymidine Kinase 1 and Thymidine Kinase 2 as an Anticancer Therapy: A Combinatorial RNAi Approach, Christine Di Cresce
Chemical Communication of Antibiotic Resistance by Highly Resistant Bacteria., Omar M. El-Halfawy
The Effect of Nutrition on the Microbiome in Pregnant Women and the Use of Micronutrient Supplemented Probiotic Yogurt to Improve Outcomes, Megan Kathleen Enos
Probiotic therapy for heart failure: Investigating the potential anti-hypertrophic properties of probiotics, Grace L. Ettinger
Sub-Inhibitory Antibiotics Enhance Virulence, Persistence, and Pathogenesis of Uropathogens, Lee W. Goneau
Evolutionary and in silico analysis of the antiviral TRIM22 gene, Jenna Kelly
Characterization of Efferosome Maturation and the Processing of Apoptotic Bodies, Yohan Kim
Indoleamine 2,3-dioxygenase confers resistance to chemotherapy and γ radiation to cancer cells, independent of direct immune involvement, Saman Maleki Vareki
The Role of KIM-1 Mediated Efferocytosis by Cancer Cells in Blocking the Immunogenicity of Tumor Cell Death, Sahra Nathoo
Role of peptidoglycan modifications in predation by Bdellovibrio bacteriovorus 109J, Diane C. Szmiett
The role of superantigens during Staphylococcus aureus nasal colonization and infection, Stacey Xu
Theses/Dissertations from 2013
The role of IL-22 produced by Th17 cells in Type 1 Diabetes, Stacey M. Bellemore
Elucidating the role of cathepsin B in the lifecycle of influenza A virus, Macon D. Coleman
Human Adenovirus E1A binds and retasks cellular hBre1, blocking interferon signalling and activating virus early gene transcription, Gregory J. Fonseca
Structure-Function Analysis of UDP-Sugar: Polyisoprenyl Phosphate Sugar-1-Phosphate Transferases, Sarah E. Furlong
Evaluating the Co-commensal Lifestyles of Staphylococcus aureus and Staphylococcus epidermidis, Piraveina Gnanasuntharam
Cellular Adaptation of Macrophages to Anthrax Lethal Toxin-Induced Pyroptosis via Epigenetic Mechanisms, Chae Young Han
The Interaction of the Human Adenovirus E1A Protein with the Human DREF Transcription Factor, Kris M. James
Systematic Assessment of the Contribution of Superantigens to Nasopharyngeal Colonization in a Mouse Model of Streptococcal Infection, Katherine J. Kasper
PEGylation as a novel tool to investigate the topology of Escherichia coli WecA, a membrane enzyme involved in lipopolysaccharide O antigen initiation, Stéphanie L. Lamothe
Role of branched-chain amino acid transporters in Staphylococcus aureus virulence, Sameha Omer
Systematic Analysis of Residues in Conserved Region 3 of the Human Papillomavirus 16 E7 Oncoprotein, Biljana Todorovic
The Role of PU.1 and Spi-B in B Cell Acute Lymphoblastic Leukemia, Shereen Turkistany
Characterization of Staphylococcus aureus Lipase, Vithooshan Vijayakumaran
Folate Receptor-Targeting Liposomes for the Delivery of Antisense Molecules to Cancer Cells, Colin J. Way
Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia, Rachel GH Ziliotto
Theses/Dissertations from 2012
Staphylococcus aureus response to long chain antimicrobial fatty acids, Benjamin Arsic
Characterization of SLP-2 function in T lymphocytes, Darah Christie
Role of IL-10 in the Immune Response to Staphylococcus aureus Nasal Carriage, Teresa Fernandez Plaza
Restriction of HIV-1 replication by unique TRIM22 isoforms., Clayton Hattlmann
Modulatory Effects Of North American Ginseng Extracts On Human Innate and Adaptive Immune Responses, Holly Rebecca Lemmon
Sequesteration of lead, cadmium and arsenic by Lactobacillus species and detoxication potential, Marc A. Monachese
The role of cystic fibrosis conductance regulator in the clearance of Burkholderia cenocepacia by macrophages, Hanna Ostapska
Immune Responses to Homocitrullinated Protein/Peptide in Rheumatoid Arthritis, Mathias J. Scinocca
The effect of dendritic cell mobilization on CD8+ T cell responses to influenza A virus, Adil N. Shivji
Theses/Dissertations from 2011
Transactivation by human Adenovirus Early Region 1A-Conserved Region Three, Jailal NG Ablack
The HIV-1 Tat Protein and Adverse Drug Reactions: A model system utilizing Jurkat T cells and sulphamethoxazole-hydroxylamine, Kaothara Adeyanju
Serum iron uptake and virulence in Staphylococcus aureus, Federico C. Beasley
The Role of Granulocyte Colony-Stimulating Factor in the Intestinal Immune System and the Response to Probiotics, Andrew J. Martins
Critical Stages in Viral Replication - Entry, Gene Regulation and Egress, Matthew S. Miller
Structure-Function Analysis of Enzymes of the Polyisoprenyl-Phosphate Hexose-1-Phosphate Transferase family, Kinnari B. Patel
The intracellular behaviour of Burkholderia cenocepacia in murine macrophages, Jennifer S. Tolman