Microbiology & Immunology Theses and Dissertations
This collection contains theses and dissertations from the Department of Microbiology & Immunology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2024
Investigating the effects of physical maturation and sexual debut on HIV-1 susceptibility in adolescent males in Rakai, Uganda, Omar Almomani
Characterizing and Applying a Nasal Organotypic Model to Investigate the Effects of Immune Profile Types on SARS-CoV-2 Susceptibility, Victor H.K. Lam
Role of monocyte-derived macrophages in critically ill patients, Yasamin Minazadeh
Effect of sodium thiosulfate pre-treatment on renal ischemia-reperfusion injury, Pierce BR Nelson
Role of Ikzf3 as a Driver Mutation in B Cell Acute Lymphoblastic Leukemia, Heidi Rysan
Assessing Helicobacter pylori's HcpE and DsbK's Effects on Immunostimulation in Host Gastric Cells, Noor Salloum
Contribution of Streptolysin O and Streptolysin S to Streptococcus pyogenes Infections in HLA-Transgenic Mice, Blake A. Shannon
Regulation of ZAP-70 post-translational modifications by HIV-1 accessory proteins Nef and Vpu, Jack E. Teplitsky
Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia, Joshua S. Yi
Investigating the role of two-component regulatory systems in regulating FnBP-A of Staphylococcus aureus, Yunqi Zhang
Theses/Dissertations from 2023
The Effect of Kidney Preservation at 10°C with Hemopure and Hydrogen Sulfide Donor, Sodium Thiosulfate, in a Syngeneic Model of Rat Renal Transplantation, Maria Abou Taka
Mechanisms of lactic acid bacteria secretions as anti-Helicobacter pylori agents, Daelyn Carroll
Investigating the clinical and microbial factors contributing to calcium-containing kidney stone disease, John A. Chmiel
Elucidating the Biomechanics of MERTK-Mediated Efferocytosis, Brandon Hayato Dickson
SARS-CoV-2 infectivity potential in municipal wastewater: Implications for public health & water treatment, Justin Donovan
Development of a high-throughput approach for testing optimal fecal microbiota transplant material, Shaeley Jae Gibbons
The Role of Mucosa-Associated Invariant T Cells in an Autochthonous Mouse Model of Bladder Cancer, Inbar A. Habaz
The Effects of Cell Envelope Localization of FnBP-A on Staphylococcus aureus FnBP-A Dependent Phenotypes, Camille LeBlanc
The Role of the MEK1/2-ERK-RSK Signalling Axis in Innate Immune Memory, Rachel Low
Identification of a PU.1-regulated repressive region in Aicda gene locus, Allanna MacKenzie
Evolution of overlapping reading frames in virus genomes, Laura Muñoz Baena
Molecular Characterization of the Antiviral Properties of the Small HERC Family of Proteins, Ermela Paparisto
Effect of pharmacological inhibition of endogenous hydrogen sulfide production on bladder cancer progression, Sydney Relouw
Exploration of the Immune Landscape of EBV-associated Gastric Cancers, Mikhail Salnikov
Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway, Steven Trothen
Characterization of T-Cell Responses to Homocitrulline in a Mouse Model of Rheumatoid Arthritis, Sofya Ulanova
Inflammation in the Neovaginal Microenvironment of Transfeminine Individuals, Hannah M.J. Wilcox
Theses/Dissertations from 2022
Investigation of the Binding and Outside-In Signalling Mechanisms of Anti-CD11d Acute Neurotrauma Therapy, Eoin N. Blythe
TetR family regulator FarR variation controls antimicrobial fatty acid efflux in Staphylococcus aureus, Camryn M. Bonn
Characterizing the Function of B Cells that Accumulate in the Inflamed Central Nervous System in Anti-Myelin Autoimmunity, Lika Chowdhury
In Vitro and In Vivo Characterization of the Metallodrug BOLD-100 as an Inhibitor of SARS-CoV-2 Replication, Daniel S. Labach
Regulation of MHC II Trafficking and Expression by Host and Viral Factors, Alex Lac
Design and Synthesis of Nef:SFK Interaction Inhibitors for Application in an Immune-directed HIV-1 Cure, Antony Lurie
Immunophenotyping and Functional Assessment of Antiviral CD8+ T Cells in a CLP Mouse Model of Immunosuppression, Alex R. Michaud
Herbicide Mediated Selection of Sulfonamide Resistant E. coli, Laura P. Muntz
Campylobacter jejuni Capsular Heptose: Moderation of Host Macrophages and Substrate Channeling During Synthesis, Matthew Myles
The role of reactive oxygen species in the accumulation of driver mutations in B cell acute lymphoblastic leukemia, Mia P. Sams
The Effect of Oral and Topical Antibiotics on Foreskin Inflammation and HIV Target Cells in Ugandan Men., Zhongtian (Eric) Shao
Screening for purine transporters in S. aureus, Tothong Sonpaveerawong
The Expanding Roles of PACS-1 and PACS-2 in Cellular Physiology: Beyond Vesicular Protein Trafficking, Rong Xuan Zang
Theses/Dissertations from 2021
Mucosa-Associated Invariant T Cells Undergo Phenotypic Changes Following Fecal Microbiota Transplantation, Jenna M. Benoit
Microbial innovations for disease management in honey bees, Brendan A. Daisley
Investigating the in vivo mechanism behind fibronectin binding protein-mediated hypervirulence of Staphylococcus aureus, Jaclyn A. Diamond
21°C is the emerging ideal temperature for kidney preservation in the presence of hydrogen sulfide, Smriti Juriasingani
Testing a Novel Peptide-Infused Cream for Treatment of Rheumatoid Arthritis in DR4tg Mice, Alisha J. Moynahan
HIV-1 Drug Resistance to Integrase Strand Transfer Inhibitors in HIV-1 non-B Subtypes, Emmanuel Ndashimye
Metabolic Reprogramming By DNA Tumour Viruses, Martin Prusinkiewicz
Metabolic origins of urogenital malodour in women and their relationship with their microbiota: can probiotics help?, Scarlett Puebla Barragan
The E26 Transformation-Specific-Family Transcription Factor Spi-C is Dynamically Regulated by External Signals in B Cells, Hannah L. Raczkowski
Generation and Characterization of an In Vitro Organotypic Foreskin Model for Future Study of the Penile Microbiome, Geoffrey J. Rempel
The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function, Patrick Rudak
A Workflow to Analyze ETHcD Mass Spectrometry Data for Studying HIV gp120 Glycosylation, Yingxue Sun
Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion, Yodit Tesfagiorgis
Characterization and Discovery of Short Linear Motifs Mediating Protein Nuclear Import, Tanner M. Tessier
The Ability of Lactobacillus spp. to Limit Extracellular ATP Release by Urogenital Bacteria, Hannah Wilcox
Differential Effects of KIM-1 in Subcutaneous and Orthotopic Renca Models of Kidney Cancer, Demitra M. Yotis DY
Protective benefits of sodium thiosulfate-supplemented UW solution against prolonged cold ischemia-reperfusion injury during renal transplantation., Max Y. Zhang Mr.
Theses/Dissertations from 2020
Characterizing the Role of the Microbiome in Kidney Stone Disease, Kaitlin F. Al
Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours, Faizah Alotaibi
HPV Mediated Antagonism of the IL-18 Proinflammatory Pathway in Head and Neck Cancer, Wyatt W. Anderson
Investigation of the growth and survival of Staphylococcus aureus in CFTR-deficient macrophages, Bita Azad
Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition, Izabela Z. Batko
Understanding Neonicotinoid Related Immunosuppression: A Potential for Beneficial Bacterial Intervention, John A. Chmiel
Exploiting the immunomodulatory potentials of iNKT cells in sepsis and cancer., Joshua Choi
Optimizing Fecal Microbiota Transplantations For Therapeutic Use Beyond Clostridioides difficile Infection, Laura J. Craven
Cell-free DNA Release During Programmed Cell Death in Kidney Ischemia Reperfusion Injury, Alexander Dionne
The development of bacterial magnetic resonance imaging for microbiota analyses, Sarah C. Donnelly
Inducing DNA-Mismatch Repair Deficiency In Tumours: A Strategy To Enhance Anti-Tumour Immunity, Mikal El-Hajjar
Investigating the Regulation of Fatty Acid Efflux Pump FarE by TetR Family Regulator FarR in Staphylococcus aureus, Katherine A. Ferguson
Elucidating the Role of Host Tim-1 in Anti-tumour Immunity, Ingrid Hon
Development and evaluation of a heterogenous virus-like particle (VLP) formulation to achieve HIV-1 latency reversal and cure., Joshua P. Pankrac
Designing a Novel HIV-1 Candidate Vaccine, Rahul Pawa
Identification of the Signalosome and Signaling Pathway of the Efferocytic Receptor MERTK, Tarannum Tasnim
Theses/Dissertations from 2019
Potential role of extracellular ATP released by bacteria in bladder infection and contractility, Behnam Abbasian
Brain-specific and systemic inflammatory response following repetitive concussive impact in a mouse model, So Young Eo
The Group A Streptococci Bacteriocins Facilitate a Competitive Advantage During Nasopharyngeal Infection, Lana Estafanos
The Epigenetic And Immune Landscapes Of HPV+ Tumor Microenvironments, Steven F. Gameiro
Utilizing FIV (Feline Immunodeficiency Virus) to develop a novel animal model to study HIV (Human Immunodeficiency Virus), Ankita Suryakant Kambli
Novel insights into the genomic integration site landscape of HIV-1 and other retrovirus genera, Hinissan P. Kohio
The role of kidney injury molecule-1 in the metastasis of renal cell carcinoma, Jasper Lee
Encountering Lectins In The Recipient Mucosa: Implications Of N-linked Glycosylation On HIV-1 Transmission, Adam Meadows
Endogenous, controlled expression of anti-HIV-1 broadly neutralizing antibody, Darshit Patel
HIV-1 Group M Subtype Fitness, Disease Progression, and Entry Efficiency, Colin M. Venner
Mucosa-Associated Invariant T Cell Roles And Local Responses In Cell-Mediated Immunity To Influenza A Virus, Christine Marie Wardell
Metabolomic and Genomic Analysis of Lactobacillus crispatus Vaginal Isolates, Emiley Watson
Virally Packaged RNA in Virus-Like Particle Vaccines Enhances Antigenicity and Augments Latency Reversal of HIV-1, Chanuka Wijewardhana
Determining the Relative Transmission Fitness of HIV-1 Subtypes A, B, C, and D, Spencer Yeung
The Role of Defective Macrophage Efferocytosis During Early Atherosclerosis in Humans, Charles Yin
Theses/Dissertations from 2018
Characterization of Urinary Microbiome and Their Association with Health and Disease, Yige Bao
Characterization of interleukin (IL)-1β regulatory elements and chromatin conformation in macrophage activation, Woohyun Cho