Microbiology & Immunology Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Microbiology & Immunology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2021

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Mucosa-Associated Invariant T Cells Undergo Phenotypic Changes Following Fecal Microbiota Transplantation, Jenna M. Benoit

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Microbial innovations for disease management in honey bees, Brendan A. Daisley

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Investigating the in vivo mechanism behind fibronectin binding protein-mediated hypervirulence of Staphylococcus aureus, Jaclyn A. Diamond

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21°C is the emerging ideal temperature for kidney preservation in the presence of hydrogen sulfide, Smriti Juriasingani

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Fishing for the right probiotic: Investigating the mechanism of mucosal-bacterial interactions at the interface of health and productivity in salmonid aquaculture, Luana Langlois

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Testing a Novel Peptide-Infused Cream for Treatment of Rheumatoid Arthritis in DR4tg Mice, Alisha J. Moynahan

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HIV-1 Drug Resistance to Integrase Strand Transfer Inhibitors in HIV-1 non-B Subtypes, Emmanuel Ndashimye

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Metabolic Reprogramming By DNA Tumour Viruses, Martin Prusinkiewicz

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Metabolic origins of urogenital malodour in women and their relationship with their microbiota: can probiotics help?, Scarlett Puebla Barragan

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The E26 Transformation-Specific-Family Transcription Factor Spi-C is Dynamically Regulated by External Signals in B Cells, Hannah L. Raczkowski

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Generation and Characterization of an In Vitro Organotypic Foreskin Model for Future Study of the Penile Microbiome, Geoffrey J. Rempel

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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function, Patrick Rudak

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A Workflow to Analyze ETHcD Mass Spectrometry Data for Studying HIV gp120 Glycosylation, Yingxue Sun

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Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion, Yodit Tesfagiorgis

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Characterization and Discovery of Short Linear Motifs Mediating Protein Nuclear Import, Tanner M. Tessier

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The Ability of Lactobacillus spp. to Limit Extracellular ATP Release by Urogenital Bacteria, Hannah Wilcox

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Differential Effects of KIM-1 in Subcutaneous and Orthotopic Renca Models of Kidney Cancer, Demitra M. Yotis DY

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Protective benefits of sodium thiosulfate-supplemented UW solution against prolonged cold ischemia-reperfusion injury during renal transplantation., Max Y. Zhang Mr.

Theses/Dissertations from 2020

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Characterizing the Role of the Microbiome in Kidney Stone Disease, Kaitlin F. Al

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Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours, Faizah Alotaibi

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HPV Mediated Antagonism of the IL-18 Proinflammatory Pathway in Head and Neck Cancer, Wyatt W. Anderson

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Investigation of the growth and survival of Staphylococcus aureus in CFTR-deficient macrophages, Bita Azad

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Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition, Izabela Z. Batko

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Understanding Neonicotinoid Related Immunosuppression: A Potential for Beneficial Bacterial Intervention, John A. Chmiel

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Exploiting the immunomodulatory potentials of iNKT cells in sepsis and cancer., Joshua Choi

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Optimizing Fecal Microbiota Transplantations For Therapeutic Use Beyond Clostridioides difficile Infection, Laura J. Craven

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Cell-free DNA Release During Programmed Cell Death in Kidney Ischemia Reperfusion Injury, Alexander Dionne

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The development of bacterial magnetic resonance imaging for microbiota analyses, Sarah C. Donnelly

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Inducing DNA-Mismatch Repair Deficiency In Tumours: A Strategy To Enhance Anti-Tumour Immunity, Mikal El-Hajjar

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Investigating the Regulation of Fatty Acid Efflux Pump FarE by TetR Family Regulator FarR in Staphylococcus aureus, Katherine A. Ferguson

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Elucidating the Role of Host Tim-1 in Anti-tumour Immunity, Ingrid Hon

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Kidney Injury Molecule-1 Mediated Phagocytosis and Its Therapeutic Application in Ameliorating Renal Transplant Ischemia Reperfusion Injury, Ji Yun Lee

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B Cell Acute Lymphoblastic Leukemia is Driven by Activating Janus Kinase Mutations Cooperating with Spi1 and Spib Deletions in a Murine Model, Michelle Lim

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Development and evaluation of a heterogenous virus-like particle (VLP) formulation to achieve HIV-1 latency reversal and cure., Joshua P. Pankrac

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Designing a Novel HIV-1 Candidate Vaccine, Rahul Pawa

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Identification of the Signalosome and Signaling Pathway of the Efferocytic Receptor MERTK, Tarannum Tasnim

Theses/Dissertations from 2019

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Potential role of extracellular ATP released by bacteria in bladder infection and contractility, Behnam Abbasian

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Brain-specific and systemic inflammatory response following repetitive concussive impact in a mouse model, So Young Eo

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The Group A Streptococci Bacteriocins Facilitate a Competitive Advantage During Nasopharyngeal Infection, Lana Estafanos

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The Epigenetic And Immune Landscapes Of HPV+ Tumor Microenvironments, Steven F. Gameiro

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Utilizing FIV (Feline Immunodeficiency Virus) to develop a novel animal model to study HIV (Human Immunodeficiency Virus), Ankita Suryakant Kambli

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Designing An Optimal HIV-1 Env Immunogen For The Vesicular Stomatitis Virus Vaccine Platform And Elucidating The Role Of HIV-1 Nef In Env Trafficking, Jason Knapp

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Novel insights into the genomic integration site landscape of HIV-1 and other retrovirus genera, Hinissan P. Kohio

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The role of kidney injury molecule-1 in the metastasis of renal cell carcinoma, Jasper Lee

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Encountering Lectins In The Recipient Mucosa: Implications Of N-linked Glycosylation On HIV-1 Transmission, Adam Meadows

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Endogenous, controlled expression of anti-HIV-1 broadly neutralizing antibody, Darshit Patel

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Role of the fibronectin-binding, collagen-binding, T-antigen region during nasopharyngeal infection by Streptococcus pyogenes, Akshay Sule

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HIV-1 Group M Subtype Fitness, Disease Progression, and Entry Efficiency, Colin M. Venner

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Mucosa-Associated Invariant T Cell Roles And Local Responses In Cell-Mediated Immunity To Influenza A Virus, Christine Marie Wardell

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Metabolomic and Genomic Analysis of Lactobacillus crispatus Vaginal Isolates, Emiley Watson

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Virally Packaged RNA in Virus-Like Particle Vaccines Enhances Antigenicity and Augments Latency Reversal of HIV-1, Chanuka Wijewardhana

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Determining the Relative Transmission Fitness of HIV-1 Subtypes A, B, C, and D, Spencer Yeung

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The Role of Defective Macrophage Efferocytosis During Early Atherosclerosis in Humans, Charles Yin

Theses/Dissertations from 2018

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Characterization of Urinary Microbiome and Their Association with Health and Disease, Yige Bao

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Characterization of interleukin (IL)-1β regulatory elements and chromatin conformation in macrophage activation, Woohyun Cho

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Determining the Molecular Mechanisms of PACS-1-mediated Protein Sorting, Brennan S. Dirk

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19F-MRI to Monitor Therapeutic Cell Migration and Distribution, Corby Fink

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Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins, Benjamin B. Fuhrmann

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Interferon-induced HERC5 is a novel and potent inhibitor of Ebola virus-like particle production, Nina Hunt

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Immunization With Recombinant Myelin Oligodendrocyte Glycoprotein Identifies Autoreactive T Cells As A Limiting Factor In Autoreactive Germinal Center Maintenance, Rajiv William Jain

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Understanding the impact of HIV-1 genetic diversity on the function of Nef and its role in SERINC5 antagonism, Aaron Leslie Johnson

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Functional and Structural Mimicry of A-Kinase Anchoring Proteins by Human Adenovirus E1A, Cason R. King

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Identification and Characterization of HIV-1 antagonists to the antiviral protein, HERC5, Divjyot S. Kochar

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Iron and Copper Homeostasis in Staphylococcus aureus, Holly A. Laakso

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Counteracting Roles for the Related E26 Transformation Specific Transcription Factors Spi-B and Spi-C in Regulating Antibody-Forming Responses, Anne-Sophie Laramee

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Effect of Bacterial Superantigens on the Magnitude and Breadth of Influenza-Specific CD8+ T Cell Responses, Courtney Meilleur

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Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses, Seyed Arad Moghadasi

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The Role of the HIV-1 Accessory Proteins Nef and Vpu in Subverting Host Cellular Immunity, Emily N. Pawlak

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The Role Of Spi-B And Pu.1 Transcription Factors In B Cell Development And In Suppression Of Leukemogenesis, Carolina Reyes Batista

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The Role of PU.1 in Lipid Metabolism and Cell Cycle Regulation in Myeloid Progenitor Cells, Jess Rhee

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Elucidation of the Signaling Pathway of MERTK, Kyle Taruc

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The Surreptitious Survival of The Emerging Pathogen Staphylococcus lugdunensis in Macrophages Enhances S. aureus Infection, David Watson

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Contribution of Enterococcus faecalis to urinary tract infection, Samantha Ann Whiteside

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Elucidating the Importance of HopE and its Potential Lewis Glycosylation in Helicobacter pylori, Keertika Yogendirarajah

Theses/Dissertations from 2017

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Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus, Heba Alnaseri

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Evaluating Evolving Leukocyte Populations In Peripheral Blood Circulation Post-Concussion In A Human Longitudinal Analysis Of Female Athletes, Kevin A. Blackney

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Discovery of Novel Diagnostic Biomarkers on Prostate Tumor Microparticles for Discriminating Between Low and High Risk Prostate Cancer and Improving Prostate Cancer Screening, Sabine Brett

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Carbohydrates and Fungal Toxin Exposure Influence the Vaginal Microbiota, Metabolome, and Reproductive Health of Women, Stephanie L. Collins

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Characterizing Ferroportin Trafficking in Macrophages During Phagocytosis, Tayler J. Farrell

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Investigating Adenovirus E1A as an RNA Polymerase II C-Terminal Domain Mimic and its Role in Transcription Activation, Kristianne JC Galpin

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Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus, Jamie N. Halucha

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Characterizing the Interaction Between Human Adenovirus E1A and STING, Jessica Hill

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Examination of BCAA Transport and Synthesis in Staphylococcus aureus, Julienne Kaiser

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Immune responses to homocitrulline- and citrulline-containing peptides in rheumatoid arthritis, Patrick Lac

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Daily Hydrogen Sulfide Treatment Enables Early Recovery of Renal Function and Mitigates Renal Injury Following the Relief of Prolonged Urinary Obstruction, Shouzhe Lin

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Rapid Regulatory and Effector Immune Responses in Toxic Shock Syndrome, Peter Anthony Szabo

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Superantigen responsive T cells are required for nasopharyngeal infection by Streptococcus pyogenes, Joseph J. Zeppa

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Characterizing the Interaction Between Human Adenovirus E1A and the Transcriptional Repressor BS69, Ali Zhang

Theses/Dissertations from 2016

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Structural and functional studies of the heptose modifying enzymes that play a role in Campylobacter jejuni virulence., Heba Soliman Barnawi

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Evolutionary History and Biological Regulation of CD93, Jack W D Blackburn

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Iron acquisition strategies employed by Staphylococcus lugdunensis, Jeremy R. Brozyna

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Evaluation of MERTK evolution and efferocytosis signalling, Amanda L. Evans

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Protective Benefits of Hydrogen Sulfide Treatment During Renal Transplantation, Ian Lobb

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Utilizing untargeted metabolomics to characterize microbial communities and identify biomarkers of an unhealthy state, Amy McMillan

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Mitigation of Pesticide Toxicity by Food-Grade Lactobacilli, Mark E. Trinder

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Characterization of microbial communities in the mammary glands and the influence of this microbiota on health and disease, Camilla Urbaniak

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At the interface of glycolipids and glycoproteins in the two gastro-intestinal pathogens Campylobacter jejuni and Helicobacter pylori, Najwa Zebian

Theses/Dissertations from 2015

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Recombinase-based in vivo expression technology identifies a Streptococcus pyogenes bacteriocin important for niche adaptation in the nasopharynx, Brent D. Armstrong

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Clinical and Mechanistic Insights into Novel Probiotic Functions and Formulations, Jordan Bisanz

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Characterizing the C-terminal Region of Human Adenovirus E1A: An Undiscovered Country, Michael J. Cohen