Microbiology & Immunology Theses and Dissertations
This collection contains theses and dissertations from the Department of Microbiology & Immunology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2022
Investigation of the Binding and Outside-In Signalling Mechanisms of Anti-CD11d Acute Neurotrauma Therapy, Eoin N. Blythe
TetR family regulator FarR variation controls antimicrobial fatty acid efflux in Staphylococcus aureus, Camryn M. Bonn
Characterizing the Function of B Cells that Accumulate in the Inflamed Central Nervous System in Anti-Myelin Autoimmunity, Lika Chowdhury
In Vitro and In Vivo Characterization of the Metallodrug BOLD-100 as an Inhibitor of SARS-CoV-2 Replication, Daniel S. Labach
Regulation of MHC II Trafficking and Expression by Host and Viral Factors, Alex Lac
Design and Synthesis of Nef:SFK Interaction Inhibitors for Application in an Immune-directed HIV-1 Cure, Antony Lurie
Immunophenotyping and Functional Assessment of Antiviral CD8+ T Cells in a CLP Mouse Model of Immunosuppression, Alex R. Michaud
Herbicide Mediated Selection of Sulfonamide Resistant E. coli, Laura P. Muntz
Campylobacter jejuni Capsular Heptose: Moderation of Host Macrophages and Substrate Channeling During Synthesis, Matthew Myles
The role of reactive oxygen species in the accumulation of driver mutations in B cell acute lymphoblastic leukemia, Mia P. Sams
The Effect of Oral and Topical Antibiotics on Foreskin Inflammation and HIV Target Cells in Ugandan Men., Zhongtian (Eric) Shao
Screening for purine transporters in S. aureus, Tothong Sonpaveerawong
The Expanding Roles of PACS-1 and PACS-2 in Cellular Physiology: Beyond Vesicular Protein Trafficking, Rong Xuan Zang
Theses/Dissertations from 2021
Mucosa-Associated Invariant T Cells Undergo Phenotypic Changes Following Fecal Microbiota Transplantation, Jenna M. Benoit
Microbial innovations for disease management in honey bees, Brendan A. Daisley
Investigating the in vivo mechanism behind fibronectin binding protein-mediated hypervirulence of Staphylococcus aureus, Jaclyn A. Diamond
21°C is the emerging ideal temperature for kidney preservation in the presence of hydrogen sulfide, Smriti Juriasingani
Testing a Novel Peptide-Infused Cream for Treatment of Rheumatoid Arthritis in DR4tg Mice, Alisha J. Moynahan
HIV-1 Drug Resistance to Integrase Strand Transfer Inhibitors in HIV-1 non-B Subtypes, Emmanuel Ndashimye
Metabolic Reprogramming By DNA Tumour Viruses, Martin Prusinkiewicz
Metabolic origins of urogenital malodour in women and their relationship with their microbiota: can probiotics help?, Scarlett Puebla Barragan
The E26 Transformation-Specific-Family Transcription Factor Spi-C is Dynamically Regulated by External Signals in B Cells, Hannah L. Raczkowski
Generation and Characterization of an In Vitro Organotypic Foreskin Model for Future Study of the Penile Microbiome, Geoffrey J. Rempel
The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function, Patrick Rudak
A Workflow to Analyze ETHcD Mass Spectrometry Data for Studying HIV gp120 Glycosylation, Yingxue Sun
Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion, Yodit Tesfagiorgis
Characterization and Discovery of Short Linear Motifs Mediating Protein Nuclear Import, Tanner M. Tessier
The Ability of Lactobacillus spp. to Limit Extracellular ATP Release by Urogenital Bacteria, Hannah Wilcox
Differential Effects of KIM-1 in Subcutaneous and Orthotopic Renca Models of Kidney Cancer, Demitra M. Yotis DY
Protective benefits of sodium thiosulfate-supplemented UW solution against prolonged cold ischemia-reperfusion injury during renal transplantation., Max Y. Zhang Mr.
Theses/Dissertations from 2020
Characterizing the Role of the Microbiome in Kidney Stone Disease, Kaitlin F. Al
Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours, Faizah Alotaibi
HPV Mediated Antagonism of the IL-18 Proinflammatory Pathway in Head and Neck Cancer, Wyatt W. Anderson
Investigation of the growth and survival of Staphylococcus aureus in CFTR-deficient macrophages, Bita Azad
Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition, Izabela Z. Batko
Understanding Neonicotinoid Related Immunosuppression: A Potential for Beneficial Bacterial Intervention, John A. Chmiel
Exploiting the immunomodulatory potentials of iNKT cells in sepsis and cancer., Joshua Choi
Optimizing Fecal Microbiota Transplantations For Therapeutic Use Beyond Clostridioides difficile Infection, Laura J. Craven
Cell-free DNA Release During Programmed Cell Death in Kidney Ischemia Reperfusion Injury, Alexander Dionne
The development of bacterial magnetic resonance imaging for microbiota analyses, Sarah C. Donnelly
Inducing DNA-Mismatch Repair Deficiency In Tumours: A Strategy To Enhance Anti-Tumour Immunity, Mikal El-Hajjar
Investigating the Regulation of Fatty Acid Efflux Pump FarE by TetR Family Regulator FarR in Staphylococcus aureus, Katherine A. Ferguson
Elucidating the Role of Host Tim-1 in Anti-tumour Immunity, Ingrid Hon
Development and evaluation of a heterogenous virus-like particle (VLP) formulation to achieve HIV-1 latency reversal and cure., Joshua P. Pankrac
Designing a Novel HIV-1 Candidate Vaccine, Rahul Pawa
Identification of the Signalosome and Signaling Pathway of the Efferocytic Receptor MERTK, Tarannum Tasnim
Theses/Dissertations from 2019
Potential role of extracellular ATP released by bacteria in bladder infection and contractility, Behnam Abbasian
Brain-specific and systemic inflammatory response following repetitive concussive impact in a mouse model, So Young Eo
The Group A Streptococci Bacteriocins Facilitate a Competitive Advantage During Nasopharyngeal Infection, Lana Estafanos
The Epigenetic And Immune Landscapes Of HPV+ Tumor Microenvironments, Steven F. Gameiro
Utilizing FIV (Feline Immunodeficiency Virus) to develop a novel animal model to study HIV (Human Immunodeficiency Virus), Ankita Suryakant Kambli
Novel insights into the genomic integration site landscape of HIV-1 and other retrovirus genera, Hinissan P. Kohio
The role of kidney injury molecule-1 in the metastasis of renal cell carcinoma, Jasper Lee
Encountering Lectins In The Recipient Mucosa: Implications Of N-linked Glycosylation On HIV-1 Transmission, Adam Meadows
Endogenous, controlled expression of anti-HIV-1 broadly neutralizing antibody, Darshit Patel
HIV-1 Group M Subtype Fitness, Disease Progression, and Entry Efficiency, Colin M. Venner
Mucosa-Associated Invariant T Cell Roles And Local Responses In Cell-Mediated Immunity To Influenza A Virus, Christine Marie Wardell
Metabolomic and Genomic Analysis of Lactobacillus crispatus Vaginal Isolates, Emiley Watson
Virally Packaged RNA in Virus-Like Particle Vaccines Enhances Antigenicity and Augments Latency Reversal of HIV-1, Chanuka Wijewardhana
Determining the Relative Transmission Fitness of HIV-1 Subtypes A, B, C, and D, Spencer Yeung
The Role of Defective Macrophage Efferocytosis During Early Atherosclerosis in Humans, Charles Yin
Theses/Dissertations from 2018
Characterization of Urinary Microbiome and Their Association with Health and Disease, Yige Bao
Characterization of interleukin (IL)-1β regulatory elements and chromatin conformation in macrophage activation, Woohyun Cho
Determining the Molecular Mechanisms of PACS-1-mediated Protein Sorting, Brennan S. Dirk
19F-MRI to Monitor Therapeutic Cell Migration and Distribution, Corby Fink
Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins, Benjamin B. Fuhrmann
Interferon-induced HERC5 is a novel and potent inhibitor of Ebola virus-like particle production, Nina Hunt
Immunization With Recombinant Myelin Oligodendrocyte Glycoprotein Identifies Autoreactive T Cells As A Limiting Factor In Autoreactive Germinal Center Maintenance, Rajiv William Jain
Understanding the impact of HIV-1 genetic diversity on the function of Nef and its role in SERINC5 antagonism, Aaron Leslie Johnson
Functional and Structural Mimicry of A-Kinase Anchoring Proteins by Human Adenovirus E1A, Cason R. King
Identification and Characterization of HIV-1 antagonists to the antiviral protein, HERC5, Divjyot S. Kochar
Iron and Copper Homeostasis in Staphylococcus aureus, Holly A. Laakso
Counteracting Roles for the Related E26 Transformation Specific Transcription Factors Spi-B and Spi-C in Regulating Antibody-Forming Responses, Anne-Sophie Laramee
Effect of Bacterial Superantigens on the Magnitude and Breadth of Influenza-Specific CD8+ T Cell Responses, Courtney Meilleur
Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses, Seyed Arad Moghadasi
The Role of the HIV-1 Accessory Proteins Nef and Vpu in Subverting Host Cellular Immunity, Emily N. Pawlak
The Role Of Spi-B And Pu.1 Transcription Factors In B Cell Development And In Suppression Of Leukemogenesis, Carolina Reyes Batista
The Role of PU.1 in Lipid Metabolism and Cell Cycle Regulation in Myeloid Progenitor Cells, Jess Rhee
Elucidation of the Signaling Pathway of MERTK, Kyle Taruc
The Surreptitious Survival of The Emerging Pathogen Staphylococcus lugdunensis in Macrophages Enhances S. aureus Infection, David Watson
Contribution of Enterococcus faecalis to urinary tract infection, Samantha Ann Whiteside
Elucidating the Importance of HopE and its Potential Lewis Glycosylation in Helicobacter pylori, Keertika Yogendirarajah
Theses/Dissertations from 2017
Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus, Heba Alnaseri
Evaluating Evolving Leukocyte Populations In Peripheral Blood Circulation Post-Concussion In A Human Longitudinal Analysis Of Female Athletes, Kevin A. Blackney
Carbohydrates and Fungal Toxin Exposure Influence the Vaginal Microbiota, Metabolome, and Reproductive Health of Women, Stephanie L. Collins
Characterizing Ferroportin Trafficking in Macrophages During Phagocytosis, Tayler J. Farrell
Investigating Adenovirus E1A as an RNA Polymerase II C-Terminal Domain Mimic and its Role in Transcription Activation, Kristianne JC Galpin
Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus, Jamie N. Halucha
Characterizing the Interaction Between Human Adenovirus E1A and STING, Jessica Hill
Examination of BCAA Transport and Synthesis in Staphylococcus aureus, Julienne Kaiser
Immune responses to homocitrulline- and citrulline-containing peptides in rheumatoid arthritis, Patrick Lac