Biochemistry Publications
Scientists in the Department of Biochemistry have expertise in genome dynamics, epigenetics, and gene expression; human genetics and clinical biochemistry; signal transduction and intracellular communication; macromolecular structure and dynamics; proteomics; and bioinformatics.
Visit the Department of Biochemistry Research website for additional information,
Submissions from 2018
BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding, Leslie J. Burke, Jan Sevcik, Gaetana Gambino, Emma Tudini, Eliseos J. Mucaki, Ben C. Shirley, Phillip Whiley, Michael T. Parsons, Kim De Leeneer, Sara Gutiérrez-Enríquez, Marta Santamariña, Sandrine M. Caputo, Elizabeth Santana dos Santos, Jana Soukupova, Marketa Janatova, Petra Zemankova, Klara Lhotova, Lenka Stolarova, Mariana Borecka, Alejandro Moles-Fernández, Siranoush Manoukian, Bernardo Bonanni, Stacey L. Edwards, Marinus J. Blok, Thomas van Overeem Hansen, Maria Rossing, Orland Diez, Ana Vega, Kathleen B.M. Claes, David E. Goldgar, and Etienne Rouleau
The clinical significance of occult gastrointestinal primary tumours in metastatic cancer: A population retrospective cohort study, Malek B. Hannouf, Eric Winquist, Salaheddin M. Mahmud, Muriel Brackstone, Sisira Sarma, George Rodrigues, Peter K. Rogan, Jeffrey S. Hoch, and Gregory S. Zaric
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy, Bojana Kravic, Angelika B. Harbauer, Vanina Romanello, Luca Simeone, F. Nora Vögtle, Tobias Kaiser, Marion Straubinger, Danyil Huraskin, Martin Böttcher, Cristina Cerqua, Eva Denise Martin, Daniel Poveda-Huertes, Andreas Buttgereit, Adam J. Rabalski, Dieter Heuss, Rüdiger Rudolf, Oliver Friedrich, David Litchfield, Michael Marber, Leonardo Salviati, Dimitrios Mougiakakos, Winfried Neuhuber, Marco Sandri, Chris Meisinger, and Said Hashemolhosseini
Predicting Response to Platin Chemotherapy Agents with Biochemically-inspired Machine Learning, Peter Rogan, Eliseos J. Mucaki, and Dan Lizotte
Pan-cancer repository of validated natural and cryptic mRNA splicing mutations, Peter Rogan, Eliseos J. Mucaki, and Ben C. Shirley
Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning, Peter Rogan, Jonathan Z.L. Zhao, and Eliseos J. Mucaki
Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS)., Jasmine S-H Wang, Shawn N Whitehead, and Ken K-C Yeung
Submissions from 2017
Protein kinase CK2: Intricate relationships within regulatory cellular networks, Teresa Nuñez de Villavicencio-Diaz, Adam J. Rabalski, and David W. Litchfield
1,6-Diphenyl-1,3,5-hexatriene (DPH) as a Novel Matrix for MALDI MS Imaging of Fatty Acids, Phospholipids, and Sulfatides in Brain Tissues., Hanadi Ibrahim, Kristina Jurcic, Jasmine S-H Wang, Shawn N Whitehead, and Ken K-C Yeung
Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection, Jin Liu, Yanxin Li, Ruth Wilkins, Canadian Nuclear Laboratories, Joan H. Knoll, and Peter Rogan
Discovery and validation of information theory-based transcription factor and cofactor binding site motifs., Ruipeng Lu, Eliseos J Mucaki, and Peter K Rogan
CK2b regulates thrombopoiesis and Ca21-Triggered platelet activation in arterial thrombosis, Patrick Münzer, Britta Walker-Allgaier, Sascha Geue, Friederike Langhauser, Eva Geuss, David Stegner, Katja Aurbach, Daniela Semeniak, Madhumita Chatterjee, Irene Gonzalez Menendez, Melanie Märklin, Leticia Quintanilla-Martinez, Helmut R. Salih, David W. Litchfield, Thierry Buchou, Christoph Kleinschnitz, Florian Lang, Bernhard Nieswandt, Irina Pleines, Harald Schulze, Meinrad Gawaz, and Oliver Borst
BIRC6 mediates imatinib resistance independently of Mcl-1, Denis O. Okumu, Michael P. East, Merlin Levine, Laura E. Herring, Raymond Zhang, Thomas S.K. Gilbert, David Litchfield, Yanping Zhang, and Lee M. Graves
Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning, Peter Rogan, Eliseos J. Mucaki, Katherina Baranova, Huy Q. Pham, Iman Rezaeian, Dimo Angelov, Alioune Ngom, and Luis Rueda
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation, Peter Rogan, Ben Shirley, Yanxin Li, and Joan Knoll
Cellular interaction influenced by surface modification strategies of gelatin-based nanoparticles, Wai Hei Tse, Laszlo Gyenis, David W. Litchfield, and Jin Zhang
Submissions from 2016
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder, Yangyang Bian, Lei Li, Mingming Dong, Xuguang Liu, Tomonori Kaneko, Kai Cheng, Huadong Liu, Courtney Voss, Xuan Cao, Yan Wang, David Litchfield, Mingliang Ye, Shawn S.C. Li, and Hanfa Zou
Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer (HBOC) Genes in Patients Lacking known BRCA Mutations., Natasha G Caminsky, Eliseos J Mucaki, Ami M Perri, Ruipeng Lu, Joan H M Knoll, and Peter K Rogan
Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning., Stephanie N Dorman, Katherina Baranova, Joan H M Knoll, Brad L Urquhart, Gabriella Mariani, Maria Luisa Carcangiu, and Peter K Rogan
GAR22β regulates cell migration, sperm motility, and axoneme structure, Ivonne Gamper, David Fleck, Meltem Barlin, Marc Spehr, Sara El Sayad, Henning Kleine, Sebastian Maxeiner, Carmen Schalla, Gülcan Aydin, Mareike Hoss, David W. Litchfield, Bernhard Lüscher, Martin Zenke, and Antonio Sechi
MTORC1 and CK2 coordinate ternary and eIF4F complex assembly, Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, and Ivan Topisirovic
Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary., M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P Rogan, J S Hoch, and G S Zaric
Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing., Yanxin Li, Joan H Knoll, Ruth C Wilkins, Farrah N Flegal, and Peter K Rogan
Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing, Yanxin Li, Joan H. Knoll, Ruth C. Wilkins, Farrah N. Flegal, and Peter K. Rogan
Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity., Andrzej Maciejewski, Valeriy G Ostapchenko, Flavio H Beraldo, Vania F Prado, Marco A M Prado, and Wing-Yiu Choy