Biochemistry Publications

 

Scientists in the Department of Biochemistry have expertise in genome dynamics, epigenetics, and gene expression; human genetics and clinical biochemistry; signal transduction and intracellular communication; macromolecular structure and dynamics; proteomics; and bioinformatics.

Visit the Department of Biochemistry Research website for additional information,

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Submissions from 2017

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Protein kinase CK2: Intricate relationships within regulatory cellular networks, Teresa Nuñez de Villavicencio-Diaz, Adam J. Rabalski, and David W. Litchfield

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1,6-Diphenyl-1,3,5-hexatriene (DPH) as a Novel Matrix for MALDI MS Imaging of Fatty Acids, Phospholipids, and Sulfatides in Brain Tissues., Hanadi Ibrahim, Kristina Jurcic, Jasmine S-H Wang, Shawn N Whitehead, and Ken K-C Yeung

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Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection, Jin Liu, Yanxin Li, Ruth Wilkins, Canadian Nuclear Laboratories, Joan H. Knoll, and Peter Rogan

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Discovery and validation of information theory-based transcription factor and cofactor binding site motifs., Ruipeng Lu, Eliseos J Mucaki, and Peter K Rogan

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CK2b regulates thrombopoiesis and Ca21-Triggered platelet activation in arterial thrombosis, Patrick Münzer, Britta Walker-Allgaier, Sascha Geue, Friederike Langhauser, Eva Geuss, David Stegner, Katja Aurbach, Daniela Semeniak, Madhumita Chatterjee, Irene Gonzalez Menendez, Melanie Märklin, Leticia Quintanilla-Martinez, Helmut R. Salih, David W. Litchfield, Thierry Buchou, Christoph Kleinschnitz, Florian Lang, Bernhard Nieswandt, Irina Pleines, Harald Schulze, Meinrad Gawaz, and Oliver Borst

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BIRC6 mediates imatinib resistance independently of Mcl-1, Denis O. Okumu, Michael P. East, Merlin Levine, Laura E. Herring, Raymond Zhang, Thomas S.K. Gilbert, David Litchfield, Yanping Zhang, and Lee M. Graves

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Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning, Peter Rogan, Eliseos J. Mucaki, Katherina Baranova, Huy Q. Pham, Iman Rezaeian, Dimo Angelov, Alioune Ngom, and Luis Rueda

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Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation, Peter Rogan, Ben Shirley, Yanxin Li, and Joan Knoll

Cellular interaction influenced by surface modification strategies of gelatin-based nanoparticles, Wai Hei Tse, Laszlo Gyenis, David W. Litchfield, and Jin Zhang

Submissions from 2016

Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder, Yangyang Bian, Lei Li, Mingming Dong, Xuguang Liu, Tomonori Kaneko, Kai Cheng, Huadong Liu, Courtney Voss, Xuan Cao, Yan Wang, David Litchfield, Mingliang Ye, Shawn S.C. Li, and Hanfa Zou

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Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer (HBOC) Genes in Patients Lacking known BRCA Mutations., Natasha G Caminsky, Eliseos J Mucaki, Ami M Perri, Ruipeng Lu, Joan H M Knoll, and Peter K Rogan

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Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning., Stephanie N Dorman, Katherina Baranova, Joan H M Knoll, Brad L Urquhart, Gabriella Mariani, Maria Luisa Carcangiu, and Peter K Rogan

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GAR22β regulates cell migration, sperm motility, and axoneme structure, Ivonne Gamper, David Fleck, Meltem Barlin, Marc Spehr, Sara El Sayad, Henning Kleine, Sebastian Maxeiner, Carmen Schalla, Gülcan Aydin, Mareike Hoss, David W. Litchfield, Bernhard Lüscher, Martin Zenke, and Antonio Sechi

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MTORC1 and CK2 coordinate ternary and eIF4F complex assembly, Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, and Ivan Topisirovic

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Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary., M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P Rogan, J S Hoch, and G S Zaric

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Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing., Yanxin Li, Joan H Knoll, Ruth C Wilkins, Farrah N Flegal, and Peter K Rogan

Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing, Yanxin Li, Joan H. Knoll, Ruth C. Wilkins, Farrah N. Flegal, and Peter K. Rogan

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Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity., Andrzej Maciejewski, Valeriy G Ostapchenko, Flavio H Beraldo, Vania F Prado, Marco A M Prado, and Wing-Yiu Choy

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A Unified Analytic Framework for Prioritization of Non-Coding Variants of Uncertain Significance in Heritable Breast and Ovarian Cancer, Eliseos J. Mucaki, Natasha G. Caminsky, Ami M. Perri, Ruipeng Lu, Alain Laederach, Matthew Halvorsen, Joan H. M. Knoll, and Peter K. Rogan

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Molecular pathways: Emergence of protein kinase CK2 (CSNK2) as a potential target to inhibit survival and DNA damage response and repair pathways in cancer cells, Adam J. Rabalski, Laszlo Gyenis, and David W. Litchfield

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Centromere detection of human metaphase chromosome images using a candidate based method, Peter Rogan

Submissions from 2015

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Beclin-1 Expression is Retained in High-Grade Serous Ovarian Cancer yet is Not Essential for Autophagy Induction In Vitro, Rohann J. M. Correa, Yudith Ramos Valdes, Trevor G. Shepherd, and Gabriel E. DiMattia

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Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells, Sarah A. Dick, Natasha C. Chang, Nicolas A. Dumont, Ryan A.V. Bell, Charis Putinski, Yoichi Kawabe, David W. Litchfield, Michael A. Rudnicki, Lynn A. Megeney, and Eric N. Olson

Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1, Brendan T. Innes, Modupeola A. Sowole, Laszlo Gyenis, Michelle Dubinsky, Lars Konermann, David W. Litchfield, Christopher J. Brandl, and Brian H. Shilton

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Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1., Halema Khan, Ryan C Killoran, Anne Brickenden, Jingsong Fan, Daiwen Yang, and Wing-Yiu Choy