Biochemistry Publications
Scientists in the Department of Biochemistry have expertise in genome dynamics, epigenetics, and gene expression; human genetics and clinical biochemistry; signal transduction and intracellular communication; macromolecular structure and dynamics; proteomics; and bioinformatics.
Visit the Department of Biochemistry Research website for additional information,
Submissions from 2010
Canadian Global Village Reality: Anthropometric Surrogate Cutoffs and Metabolic Abnormalities among Canadians of East Asian, South Asian, and European Descent, Meizi He, E. T. S. Li, Stewart Harris, Murray W. Huff, Chun Y. Yau, and G. Harvey Anderson
A Cancer Derived Mutation in the Retinoblastoma Gene with a Distinct Defect for LXCXE Dependent Interactions, Shauna A. Henley, Sarah M. Francis, Jordan Demone, Peter Ainsworth, and Frederick A. Dick
An Overlapping Kinase and Phosphatase Docking Site Regulates Activity of the Retinoblastoma Protein, Alexander Hirschi, Matthew Cecchini, Rachel C. Steinhardt, Michael R. Schamber, Frederick A. Dick, and Seth M. Rubin
Increased Blood Pressure and Hyperdynamic Cardiovascular Responses in Carriers of a Common Hyperfunctional Variant of Adenylyl Cyclase 6, Gary J. Hodges, Robert Gros, Robert A. Hegele, Stan Van Uum, J. Kevin Shoemaker, and Ross D. Feldman
Mutational Analysis of the C-terminal FATC Domain of Saccharomyces Cerevisiae Tra1, Stephen M. T. Hoke, A. Irina Mutiu, Julie Genereaux, Stephanie Kvas, Michael Buck, Michael Yu, Gregory B. Gloor, and Christopher J. Brandl
The Fibroblast Growth Factor Receptor Substrate 3 Adapter Is a Developmentally Regulated Microtubule-associated Protein Expressed in Migrating and Differentiated Neurons, Todd Hryciw, James I. S. MacDonald, Renée Phillips, Claudia Seah, Stephen Pasternak, and Susan O. Meakin
Matrigel: A Complex Protein Mixture Required for Optimal Growth of Cell Culture, Chris S. Hughes, Lynne M. Postovit, and Gilles A. Lajoie
Deep Sequencing of the Vaginal Microbiota of Women with HIV, Ruben Hummelen, Andrew D. Fernandes, Jean M. Macklaim, Russell J. Dickson, John Changalucha, Gregory B. Gloor, and Gregor Reid
Insulin-like Growth Factor Binding Protein-6 (IGFBP-6) Interacts with DNA-end Binding Protein Ku80 to Regulate Cell Fate, Cristiana Iosef, Gregory Vilk, Theofanis Gkourasas, Kyung-Jong Lee, Benjamin P. C. Chen, Ping Fu, Leon A. Bach, Gilles Lajoie, Madhulika B. Gupta, Shawn S. C. Li, and Victor K. Han
A Novel Mechanism of Cell Growth Regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1, Yan Jiang, Vineshkumar T Puliyappadamba, Liyue Zhang, Wenjuan Wu, Anil Wali, Michael B. Yaffe, Joseph A. Fontana, and Arun K. Rishi
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit, Christopher T. Johansen, Zane R. Gallinger, Jian Wang, Matthew R. Ban, T. Kue Young, Peter Bjerregaard, and Robert A. Hegele
Translating Genomic Analyses into Improved Management of Coronary Artery Disease, Christopher T. Johansen, Matthew B. Lanktree, and Robert A. Hegele
Excess of Rare Variants in Genes Identified by Genome-wide Association Study of Hypertriglyceridemia, Christopher T. Johansen, Jian Wang, Matthew B. Lanktree, Henian Cao, Adam D. McIntyre, Matthew R. Ban, Rebecca A. Martins, Brooke A. Kennedy, Reina G. Hassell, Maartje E. Visser, Stephen M. Schwartz, Benjamin F. Voight, Roberto Elosua, Veikko Salomaa, Christopher J. O'Donnell, Geesje M. Dallinga-Thie, Sonia S. Anand, Salim Yusuf, Murray W. Huff, Sekar Kathiresan, and Robert A. Hegele
In Vivo Detection of PARACEST Agents with Relaxation Correction, Craig K. Jones, Alex X. Li, Mojmír Suchý, Robert H. E. Hudson, Ravi S. Menon, and Robert Bartha
Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets, Tomonori Kaneko, Haiming Huang, Bing Zhao, Lei Li, Huadong Liu, Courtney K. Voss, Chenggang Wu, Martin R. Schiller, and Shawn Shun-Cheng Li
Mammalian Numb-interacting Protein 1/Dual Oxidase Maturation Factor 1 Directs Neuronal Fate in Stem Cells, Karen A. M. Kennedy, Elena A. Ostrakhovitch, Shelley D. E. Sandiford, Thamara Dayarathna, Xiaojun Xie, Elaine Y. L. Waese, Wing Y. Chang, Qingping Feng, Ilona S. Skerjanc, William L. Stanford, and Shawn S. C. Li
ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain, Kristin D. Kernohan, Yan Jiang, Deanna C. Tremblay, Anne C. Bonvissuto, James H. Eubanks, Mellissa R. W. Mann, and Nathalie G. Bérubé
A Unified Genetic, Computational and Experimental Framework Identifies Functionally Relevant Residues of the Homing Endonuclease I-BmoI, Benjamin P. Kleinstiver, Andrew D. Fernandes, Gregory B. Gloor, and David R. Edgell
Laminar Flow Effects During Laser-Induced Oxidative Labeling for Protein Structural Studies by Mass Spectrometry, Lars Konermann, Bradley B. Stocks, and Tomasz Czarny
Mass Spectrometry Combined with Oxidative Labeling for Exploring Protein Structure and Folding, Lars Konermann, Bradley B. Stocks, Yan Pan, and Xin Tong
Toenail Selenium Status and DNA Repair Capacity among Female BRCA1 Mutation Carriers, Joanne Kotsopoulos, Zhou Chen, Katherine A. Vallis, Aletta Poll, Parviz Ghadirian, Greg Kennedy, Peter Ainsworth, and Steven A. Narod
APOC1 T45S Polymorphism Is Associated with Reduced Obesity Indices and Lower Plasma Concentrations of Leptin and Apolipoprotein C-I in Aboriginal Canadians, Piya Lahiry, Henian Cao, Matthew R. Ban, Rebecca L. Pollex, Mary Mamakeesick, Bernard Zinman, Stewart B. Harris, Anthony J. G. Hanley, Murray W. Huff, Philip W. Connelly, and Robert A. Hegele
Kinase Mutations in Human Disease: Interpreting Genotype-phenotype Relationships, Piya Lahiry, Ali Torkamani, Nicholas J. Schork, and Robert A. Hegele
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians, Matthew B. Lanktree, Sonia S. Anand, Salim Yusuf, Robert A. Hegele, and SHARE Investigators
Advances in Genomic Analysis of Stroke: What Have We Learned and Where Are We Headed?, Matthew B. Lanktree, Martin Dichgans, and Robert A. Hegele