Biochemistry Theses and Dissertations
This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2017
Regulation of C-RAF stability by the RanBPM/CTLH complex, Christina J. McTavish
Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2, Adam J. Rabalski
Investigating E2F independent cell cycle control and tumor suppression by pRB, Michael J. Thwaites
An invasive tumor cell subpopulation as a therapeutic target in breast cancer, Tahereh Vakili
Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response, Elizabeth A. Walden
Structural and Functional Characterization of Non-Homologous End Joining Factors, Huasheng Wang
Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity, Alanna R. Watson
Dual-active genome-editing reagents, Jason M. Wolfs
Investigation of the Interactions between Elg1 and PCNA Involved in the DNA Damage Response, Jingwei Yan
Investigating the Regulatory Circuitry of Protein Kinases and Proteases in Apoptosis, Stephanie A. Zukowski
Theses/Dissertations from 2016
Investigating the Role of Extracellular Matrix Proteins in Ovarian Folliculogenesis and Ovarian Cancer, Alexandra Carrier
Characterization of the catalytic CK2 subunits with substitutions at residues involved in inhibitor binding, Paul Desormeaux
Assessing the role of the ATRX chromatin remodeling protein in myelination within the mouse central nervous system, Matthew W. Edwards
Riboregulation of Bacterial Transposons, Michael J. Ellis
Gene Discovery in Mendelian and Complex Diseases, Sali Farhan
Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants, Susanna George
Interaction of SecA with Unfolded Polypeptides, Aliakbar Khalili Yazdi
Insights into Chibby's structural elements and their interplay in Wnt signaling protein-protein interactions, Ryan C Killoran
Using mutual information to reprogram DNA specificity of LAGLIDADG endonucleases, Marcon Laforet
The Role of Sirtuin 6 in Maintaining Vascular Integrity, Sharon Z. Leung
Structural Analysis of TPR Ligand Complexes of STIP1 Implicated in Alzheimer's Disease, Andrzej Maciejewski
Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease, Alexander S. McCarton
Examining the role of ATRX in astrocytes, Haley McConkey
Nucleoporin-mediated regulation of the Kcnq1ot1 imprinted domain, Saqib Sachani
Characterization of RanBPM Subcellular Localization and Function in HDAC6 Regulation, Louisa M. Salemi
Prevention of Murine Atherosclerosis with Bempedoic Acid, Joshua P. Samsoondar
Characterization of NUMB as a Regulator of Anaplastic Lymphoma Kinase, Ran Wei
Assisted Reproductive Technologies Disrupt Genomic Imprinting in Human and Mitochondria in Mouse Embryos, Carlee R. White
Measuring the human gut microbiome: new tools and non alcoholic fatty liver disease, Ruth G. Wong
Theses/Dissertations from 2015
Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation, Adrian Buensuceso
A Unified Framework for the Prioritization of Variants of Uncertain Significance in Hereditary Breast and Ovarian Cancer Patients, Natasha G. Caminsky
Interpretation of Mutations, Expression, Copy Number in Somatic Breast Cancer: Implications for Metastasis and Chemotherapy, Stephanie Dorman
Investigating the Binding of Peptidyl-Prolyl Isomerase Pin1 to a Multi-Site Phosphorylated Substrate Modeled After Phosphatase CDC25C, Michelle K. Dubinsky
Interdomain interactions of the transactive response DNA binding protein 43 kDa (TDP-43), Karen M. Dunkerley
The Rational Design and Evaluation of CK2alpha Mutants Bearing Inhibitor-Refractory Amino Acid Substitutions, Sam Reid Fess
Chemical Biology Approaches to Investigate the Activity and Substrate Specificity of Protein Kinase CK2, Michelle A. Gabriel
Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage, Krista M. Hawrylyshyn
Characterizing the Function of Helix Five of the Ku70 von Willebrand A Domain in Non-Homologous End Joining, Sarah M. Hoffer
Quinone Reductase 2 is a Flavin Redox Switch, Kevin Ka Ki Leung
The role of thymine DNA glycosylase (TDG) and DNA demethylation in TGF beta signaling, Matthew E.R. Maitland
Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation to IGFBP-1 Hyperphosphorylation in Fetal Growth Restriction, Niyati M. Malkani
The role of bone sialoprotein in the tendon-bone insertion, Ryan M. Marinovich
Examining the Nucleotide Preference of the Linker Domain in Engineered Tev-mTALENs, Brendon C. McDowell
Investigating the role of the extracellular matrix protein, Spondin 1, in ovarian folliculogenesis, Caitlin O'Flynn
Isolation and Characterisation of Relaxed Specificity I-TevI Nuclease Domain Mutants, Alexander C. Roy
The Epigenetic Regulators ATRX and CTCF are Required for Mouse Neuroprogenitor Cell Survival and Brain Development, Lauren Ashley Watson
Theses/Dissertations from 2014
Investigating the Role of Retinoblastoma Protein and Transforming Growth Factor-Beta in Growth Inhibition, Mehdi Amiri
Characterizing the interaction between RanBPM and c-Raf, Wesley Berube-Janzen
The role of the arginine methyltransferase CARM1 in global transcriptional regulation., Niamh Coughlan
The Roles of Matrix-Associated Periostin in an In Vitro Model of Hypertrophic Scarring, Justin D. Crawford
Regulation of IGFBP-1 Phosphorylation in Hypoxia Via mTOR Signaling, Ian Damerill
Maternal Control of Genomic Imprinting: Effects of Infertility and Ovarian Stimulation in a Mouse Model, Michelle M. Denomme
Regulation of SAGA by the N-terminus of Spt7 in Saccharomyces cerevisiae, Dominik Dobransky
The Effects of RHAMM on Cell Division, Cell Motility, and Tumorigenesis, Sallie Elhayek
The Role of the Ku70 vWA Domain in the Response to DNA Double Strand Breaks, Victoria L. Fell
Bone Sialoprotein and Osteopontin Mediate Bone Development, Erik Martin Holm
Targeted Proteomics of Human Pluripotent Stem Cells, Kevin Gregory Kania
Mechanistics of Prothymosin alpha and Nrf2 in the Keap1-Nrf2 mediated Oxidative Stress Response, Halema Khan
The Role of the Pre-Sensor 1 β Hairpin in Minichromosome Maintenance 2-7 Function, Simon K. W. Lam
Regulation of the Kcnq1ot1 Imprinting Domain in Mouse, Lauren SM Landschoot
Characterization of the anti-apoptotic function of the lysine demethylase plant homeodomain finger protein 8 (PHF8), Kimberly Muranko
Investigation of β-Catenin-Mediated Regulation of IGFBP-6 and the Roles of IGFBP-6 and IGF-II in Dupuytren's Disease, Christina N. Raykha
Host-imposed regulation of bacterial transposons Tn10 and Tn5, Joseph A. Ross
Post-Translational Control of Retinoblastoma Protein Phosphorylation, Paul M. Stafford
The Role of Oxygen Tension and Insulin-Like Growth Factor Signaling in the Placental Mesenchymal Stem Cell Fate, Amer Youssef
Theses/Dissertations from 2013
Resolving the Genetic Etiology of Hypercholesterolemia in Familial Combined Hyperlipidemia, Mary A. Bamimore
Regulation of Lipid Homeostasis, Inflammatory Signalling and Atherosclerosis by the Peroxisome Proliferator-Activated Receptor Delta, Lazar A. Bojic
Features of Dormancy in Metastatic Ovarian Cancer Cells, Rohann JM Correa
Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression, Courtney H. Coschi
Regulation of eukaryotic Mcm2-7 activity, Lance F. DaSilva
Computational Molecular Coevolution, Russell J. Dickson
Detection, prioritization and analysis of variants of unknown significance in familial breast cancer genes, Eddie A. Dovigi
Genetic approaches to studying complex human disease, Joseph B. Dube
Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1, Brendan T. Innes
DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases, Benjamin P. Kleinstiver
Characterizing the human vaginal microbiome using high-throughput sequencing, Jean Megan E. Macklaim
Structure of C-terminal Domain of Parkin, IBR-RING2, Yeong Ju Noh
Insights into the Function of the FATC Domain of Saccharomyces Cervisiae TRA1 via Mutation and Suppressor Analysis, Samantha A. Pillon
The Chromatin Remodeling Protein ATRX in Development and Maintenance of Mouse Skeletal Tissues, Lauren A. Solomon
Identification of the Salivary Proteome in Children Throughout the Course of Dental Eruption, Nada Tabbara
Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression, Srikanth Talluri
Transcriptional Regulation by the Oncogenic ZNF217/CoREST Complex, Gobi Thillainadesan
Investigating the interplay between protein kinases and caspases, Jacob P. Turowec
Characterization of the Interaction Between Bone Sialoprotein and Type I Collagen, Rose Yee
Theses/Dissertations from 2012
Characterization of a tumour suppressor function of RanBPM, Elnaz Atabakhsh
Experimental and computational analysis of the structure and dynamics of intrinsically disordered proteins, Elio Anthony Cino
Telomere length dynamics in aging mice, Paul J. Comartin
Investigating Binding Partners of the Neuronal Adaptor Protein ShcC Involved in Learning and Memory, Kayla RM Driver
Structural and Bioinformatic Analysis of the b Subunit of F-ATP synthase, Ardeshir Goliaei
Mass Spectrometry-Based Proteomics Analysis of the Matrix Microenvironment in Pluripotent Stem Cell Culture, Christopher Hughes
Regulation of the bacterial transposon Tn5, Crystal R. McLellan
The Regulation of Prokaryotic Transposable Elements by the RNA Binding Protein Hfq, Brian J. Munshaw
Structural Characterization of Protein Folding Intermediates by Oxidative Labeling and Mass Spectrometry, Bradley B. Stocks
The cross talk between TrkB and NMDA receptors through RasGrf1, Asghar Talebian
Investigation of histone lysine methylation in stem cell differentiation using inhibitor peptide, Wendy Zhu