Biochemistry Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2013

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Regulation of Lipid Homeostasis, Inflammatory Signalling and Atherosclerosis by the Peroxisome Proliferator-Activated Receptor Delta, Lazar A. Bojic

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Features of Dormancy in Metastatic Ovarian Cancer Cells, Rohann JM Correa

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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression, Courtney H. Coschi

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Regulation of eukaryotic Mcm2-7 activity, Lance F. DaSilva

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Computational Molecular Coevolution, Russell J. Dickson

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Detection, prioritization and analysis of variants of unknown significance in familial breast cancer genes, Eddie A. Dovigi

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Genetic approaches to studying complex human disease, Joseph B. Dube

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Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1, Brendan T. Innes

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DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases, Benjamin P. Kleinstiver

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Characterizing the human vaginal microbiome using high-throughput sequencing, Jean Megan E. Macklaim

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Structure of C-terminal Domain of Parkin, IBR-RING2, Yeong Ju Noh

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Insights into the Function of the FATC Domain of Saccharomyces Cervisiae TRA1 via Mutation and Suppressor Analysis, Samantha A. Pillon

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The Chromatin Remodeling Protein ATRX in Development and Maintenance of Mouse Skeletal Tissues, Lauren A. Solomon

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Identification of the Salivary Proteome in Children Throughout the Course of Dental Eruption, Nada Tabbara

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Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression, Srikanth Talluri

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Transcriptional Regulation by the Oncogenic ZNF217/CoREST Complex, Gobi Thillainadesan

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Investigating the interplay between protein kinases and caspases, Jacob P. Turowec

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Characterization of the Interaction Between Bone Sialoprotein and Type I Collagen, Rose Yee

Theses/Dissertations from 2012

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Characterization of a tumour suppressor function of RanBPM, Elnaz Atabakhsh

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Characterization of the Interaction between the Parkin Ubiquitin-like domain and Ataxin-3 Ubiquitin Interacting Domains, Jane J. Bai

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Experimental and computational analysis of the structure and dynamics of intrinsically disordered proteins, Elio Anthony Cino

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Telomere length dynamics in aging mice, Paul J. Comartin

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Investigating Binding Partners of the Neuronal Adaptor Protein ShcC Involved in Learning and Memory, Kayla RM Driver

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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain, Sarah J. Gamble

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Structural and Bioinformatic Analysis of the b Subunit of F-ATP synthase, Ardeshir Goliaei

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Mass Spectrometry-Based Proteomics Analysis of the Matrix Microenvironment in Pluripotent Stem Cell Culture, Christopher Hughes

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Regulation of the bacterial transposon Tn5, Crystal R. McLellan

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The Regulation of Prokaryotic Transposable Elements by the RNA Binding Protein Hfq, Brian J. Munshaw

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Structural Characterization of Protein Folding Intermediates by Oxidative Labeling and Mass Spectrometry, Bradley B. Stocks

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The cross talk between TrkB and NMDA receptors through RasGrf1, Asghar Talebian

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Investigation of histone lysine methylation in stem cell differentiation using inhibitor peptide, Wendy Zhu

Theses/Dissertations from 2011

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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis., Matthew J. Cecchini

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Structural Characterization of HIP2 Enzyme Interactions in Ubiquitination, Benjamin W. Cook

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ATPase Regulation in the Maltose Transporter, Alister D. Gould

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Elucidating the genetic determinants of the archetypal complex disease hypertriglyceridemia, Christopher T. Johansen

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Structural Role of S100 Proteins in Membrane Repair, Atoosa Rezvanpour

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The Regulation of Cell Division and Neurogenesis by the Chromatin Remodeling Protein ATRX, Kieran L. Ritchie

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Maternal and Fetal Plasma Protein Changes in Fetal Growth Restriction, Maxim D. Seferovic

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The Effects of Superovulation and Embryo Culture on Genomic Imprinting in a Mouse Model System, Brenna A. M. Velker

Theses/Dissertations from 2010

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Structural insights into DNA replication and lesion bypass by Y family DNA polymerases, Kevin N. Kirouac

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Identification of Regions Responsible for the Open Conformation of S100A10 Using Chimaeric S100A11/S100A10 Proteins, Liliana Santamaria-Kisiel

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Mitotic Regulation of Protein Kinase CK2, Nicole A. St. Denis

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The role of the Mcm2 subunit in regulating the activities of the Mcm2-7 helicase, Brent E. Stead