Biochemistry Theses and Dissertations
This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2024
Human transfer RNA anticodon variants suppress pathogenic nonsense mutations, Aruun Beharry
Proteomic characterization of LIN28A-driven resistance to imatinib in Chronic Myeloid Leukemia, Owen F. J. Hovey
Investigating the Dynamic Composition, Subcellular Localization, and Functions of the Human C-terminal to LisH Complex, Gabriel Onea
Resolving the Longitudinal Triglyceride Phenotype of Heterozygous LPL and Apo A-V Deficiency, Shehan D. Perera
Elucidating the temporal regulation of protein kinase CK2 by the peptidyl-prolyl isomerase Pin1, Scott E. Roffey
Delivery and differentially phosphorylated AKT1 regulation in mammalian cells, Tarana Siddika
Transfer RNA Missense Suppressors in Nature and Disease, Rasangi Tennakoon
Kinome and Phosphor-proteome Dynamics of TCR/PD-1 Signalling and Strategies of Blocking PD-1 Signaling for Novel Immunotherapy, Shanshan Zhong
Theses/Dissertations from 2023
Genetic Tools Towards A Synthetic Biology Approach For Whole Mitochondrial Genome Engineering, Ryan R. Cochrane
Multi-omics analysis of epithelial ovarian cancer metastasis, Mallory I. Frederick
Functionalizing conjugative systems to deliver CRISPR nucleases for targeted bacterial killing, Thomas A. Hamilton
Characterizing SaCas9 and SaCas9[D10E] tolerance to mismatches using Directed Evolution Using Fluorescence Activated Cell Sorting (DEUFACS), Olha Haydaychuk
The inner workings of thrombin-activatable fibrinolysis inhibitor: a study of the TM-mediated activation of TAFI and inactivation of TAFIa, Haley D N Marier
Advances in Phaeodactylum tricornutum nuclear engineering, Mark Pampuch
Developing Regulated CRISPR Systems to Control Bacterial Microbiomes, Gregory M. Pellegrino
State-of-the-art Approaches for Sequencing, Assembling and Annotating Naphthenic Acid Degrading Bacterial Metagenomes, Henry H. Say
Mechanism of Permissive Cleavage Activity of TevCas12a, Alexa White
Acetylation regulates Thioredoxin Reductase activity and oligomerization, DAVID E. WRIGHT
Kinetic Analyses of SaCas9[D10E] in vitro, Claire Zhang
Theses/Dissertations from 2022
The development of Sinorhizobium meliloti and Deinococcus radiodurans as chassis for synthetic biology applications, Stephanie L. Brumwell
Applications of nanopore DNA sequencing for improved genome assembly, Daniel Giguere
Dual Functions of Interstrand Crosslink Repair Nuclease SNM1A, Ryan Grainger
Probing the genetic code with Leucine tRNA variants, Peter Anderson Hall
Perseverance of protein homeostasis despite mistranslation, Farah Hasan
Towards more complete metagenomic analyses through circularized genomes and conjugative elements, Benjamin R. Joris
Dissecting the Molecular Basis of NRF2 Activity Modulation in the Oxidative Stress Response, Nadun Karunatilleke
Chromatin regulation by RB-interacting proteins in cellular immune functions, Seung June Kim
Identification and characterization of novel fumonisin-detoxifying enzymes, Michael C. Kovacevic
Kinetic and structural influences of acetylation on ubiquitin processing, Rachel E. Lacoursiere
Illuminating Transfer RNA Variants as Genetic Modifiers in Models of Human Disease, Jeremy T. Lant
RHAMM as a biomarker and therapeutic target in triple-negative breast cancer, Britney Messam
Characterization of disease-causing HARS mutations, Yi Qiu
Global Regulation of miRNA and mRNA Homeostasis by Terminal Uridylyltransferases TENT3A/B, Pengcheng Zhang
Theses/Dissertations from 2021
Mapping Ku70 Protein Interactions Using Proximity-Dependent Biotin Identification, Sanna Abbasi
Applications of Genetic Testing for Endocrine and Metabolic Disorders, Amanda Berberich
Implications and Applications of Transfer RNA Variants that Mistranslate the Genetic Code, Matthew D. Berg
Biochemical and biophysical characterization of a novel fumonisin detoxifying enzyme from Aspergillus niger, Shane G. Butler
Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations, Megan Nicole Chang
Investigating The Role Of PKC And Its Mechanisms In Regulation Of IGF-I Bioavailability In Fetal Growth Restriction, Allan W. Chen
The Genetic Landscape of Neurodegenerative and Cerebrovascular Disease Phenotypes., Allison A. Dilliott
New Perspectives on Phosphorylation State in the Parkin Ubiquitination Cascade, Karen Dunkerley
The study of the structure and dynamics of parkin activation, Elaine Aisha Freeman
Development of 3D Bioartificial Human Tissue Models of Periprosthetic Shoulder Joint Infection, Tony B. Huang
tRNA Regulation in Humans: The cellular effect of a pathological HARS Y454S mutation, Rosan Kenana
Genetic Approaches for the Study of Complex Human Diseases, Julieta Lazarte
Uncovering the ubiquitin ligase activity and substrates of the human C-terminal to LisH (CTLH) complex, Matthew E.R. Maitland
Characterizing the Role of TDG in FXR-dependent Signaling, Oladapo A. Onabote
Functional Role of DREAM and DYRK1A in High-Grade Serous Ovarian Cancer Cell Dormancy, Pirunthan Perampalam
Disruption of Insertion Sequence 200 (IS200) leads to a premature induction of the Cysteine regulon in Salmonella Typhimurium, Naomi-Jean Q. Scherba
A Characterization of RGNEF Biophysical Properties and Interactome, Brooke E. Wile
Theses/Dissertations from 2020
Nutrient Sensing Pathways Mediating IGFBP1 Phosphorylation in FGR, Shapnil Bhuiyan
The Genetic Determinants of Complex Lipid and Lipoprotein Phenotypes, Jacqueline S. Dron
Development of a Thermosensitive Endonuclease to Act as a Plasmid Kill-Switch, Christopher D. Leichthammer
AWT1 is Constantly Expressed in Palmar Fascia Fibrosis and Promotes a Pro-Inflammatory Milieu, Johnny Luo
Practical Applications and Future Directions of Genetic Code Expansion: Validation of Novel Akt1 Substrates and the Design of a Synthetic Auxotroph Strain of B. subtilis, McShane M. McKenna
Deciphering the CK2-dependent phosphoproteome and its integration with regulatory PTM networks, Teresa Nunez de Villavicencio Diaz
Generation of Conditional Ku70 Knockouts in Human Cell Lines Using CRISPR/Cas9 and Dual-Nuclease CRISPR/TevCas9, Gursimran Parmar
Thyroxine-Dependent and -Independent Effects on Premature Aging and Myelination in ATRX Mutant Mice, Megan E. Rowland
Development of the Model Marine Diatom Phaeodactylum tricornutum for Synthetic Biology Applications, Samuel S. Slattery
The role of Heat Shock Protein 90 in the Keap1/Nrf2 Mediated Oxidative-Stress Response, Zheng Song
Structural Study of the Complex Between DNA Polymerase Iota and Ub-PCNA, Harrison Taylor
Quinone Reductase 2 Roles in Proteomic Regulation and Response to Treatment with Clinical Drugs, Matthew D. Walker
Calcium signaling and pathogenesis of dysferlin C2 domains, Yuning Wang
Theses/Dissertations from 2019
Placental MicroRNA Expression in Pregnancies Complicated with Preeclampsia and Intrauterine Growth Restriction, Zain Awamleh
Differentially activating the oncogenic kinase Akt1, Nileeka Balasuriya
Regulation of RNA stability by terminal nucleotidyltransferases, Christina Z. Chung
The Characterization of the Rat Bone Sialoprotein Knockout Phenotype, Benjamin Harvey
Improving the genetic diagnosis of familial hypercholesterolemia, Michael Iacocca
Applications of Phosphotyrosine Superbinding SH2 Domain Variants, Xuguang Liu
Functional investigation of the role of the retinoblastoma protein in genome stability, Aren E. Marshall
Structure and Function of Stomatin-like Protein 2, Safee Mian
Nobiletin Corrects Intestinal Insulin Resistance and Lipid Metabolism in Ldlr-/- Mice Fed a High-fat Diet, Nadya Morrow
Systematic identification of the lysine methylome using methyllysine binding domains, Wen Qin
Investigating the Role of ATRX in Glutamatergic Hippocampal Neurons, Renee Tamming
Structural and Functional Characterization of Deinococcal DNA Damage Response A (DdrA), Filip Todorovic
Parkin Structural Perturbations in Oxidative Stress, An Tran
Mass Spectrometry-Based Proteomics Analysis Of Bioactive Proteins In EMD That Modulate Adhesion Of Gingival Fibroblast To Improve Bio-Integration Of Dental Implants, David Zuanazzi Machado Jr
Theses/Dissertations from 2018
Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin, Amy C. Burke
Regulation of Beta-Catenin by the CTLH Complex, Christopher Chiasson
Conformational Arrangements of UbcH7-Ubiquitin with OspG and Parkin, Tara E. C. Condos
Chromatin organizer CTCF in brain development and behaviour, Adrienne Elbert
Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo, Mohammad Haider Hassan
Genetic determinants underlying rare diseases identified using next-generation sequencing technologies, Rosettia Ho
The Role of Thymine-DNA Glycosylase In Transcriptional Regulation, Bart Kolendowski
Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR), Bethany N. Radford
The Functional Characterization of the N-terminal Domains of TUT4, Lauren E. Seidl
Theses/Dissertations from 2017
Autoinhibition and Activation of Parkin, Jacob D. Aguirre
Characterizing the Cofactor Specificity of NQO2, Shahed Al Massri
Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation, Katelyn Cousteils
An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha, Edward Cruise
Effect on Pellicle Proteome upon Adsorption of Salivary Peptide on Hydroxyapatite and their effects on Enamel Demineralization, Rajesh Kr. Gupta
Tti2 in PIKK Biosynthesis and Its Use in Identifying Missense Suppressor tRNAs, Kyle S. Hoffman
The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences, Charles A. Ishak
Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration, Miljan Kuljanin
Coevolving Residues and the Expansion of Substrate Permissibility in LAGLIDADG Homing Endonucleases, Thomas A. McMurrough