Biochemistry Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2022

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The development of Sinorhizobium meliloti and Deinococcus radiodurans as chassis for synthetic biology applications, Stephanie L. Brumwell

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Applications of nanopore DNA sequencing for improved genome assembly, Daniel Giguere

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Dual Functions of Interstrand Crosslink Repair Nuclease SNM1A, Ryan Grainger

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Perseverance of protein homeostasis despite mistranslation, Farah Hasan

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Towards more complete metagenomic analyses through circularized genomes and conjugative elements, Benjamin R. Joris

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Identification and characterization of novel fumonisin-detoxifying enzymes, Michael C. Kovacevic

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Kinetic and structural influences of acetylation on ubiquitin processing, Rachel E. Lacoursiere

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Illuminating Transfer RNA Variants as Genetic Modifiers in Models of Human Disease, Jeremy T. Lant

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Characterization of disease-causing HARS mutations, Yi Qiu

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Global Regulation of miRNA and mRNA Homeostasis by Terminal Uridylyltransferases TENT3A/B, Pengcheng Zhang

Theses/Dissertations from 2021

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Mapping Ku70 Protein Interactions Using Proximity-Dependent Biotin Identification, Sanna Abbasi

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Applications of Genetic Testing for Endocrine and Metabolic Disorders, Amanda Berberich

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Implications and Applications of Transfer RNA Variants that Mistranslate the Genetic Code, Matthew D. Berg

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Biochemical and biophysical characterization of a novel fumonisin detoxifying enzyme from Aspergillus niger, Shane G. Butler

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Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations, Megan Nicole Chang

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Investigating The Role Of PKC And Its Mechanisms In Regulation Of IGF-I Bioavailability In Fetal Growth Restriction, Allan W. Chen

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The Genetic Landscape of Neurodegenerative and Cerebrovascular Disease Phenotypes., Allison A. Dilliott

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New Perspectives on Phosphorylation State in the Parkin Ubiquitination Cascade, Karen Dunkerley

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The study of the structure and dynamics of parkin activation, Elaine Aisha Freeman

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Development of 3D Bioartificial Human Tissue Models of Periprosthetic Shoulder Joint Infection, Tony B. Huang

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tRNA Regulation in Humans: The cellular effect of a pathological HARS Y454S mutation, Rosan Kenana

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Genetic Approaches for the Study of Complex Human Diseases, Julieta Lazarte

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Uncovering the ubiquitin ligase activity and substrates of the human C-terminal to LisH (CTLH) complex, Matthew E.R. Maitland

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Characterizing the Role of TDG in FXR-dependent Signaling, Oladapo A. Onabote

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Functional Role of DREAM and DYRK1A in High-Grade Serous Ovarian Cancer Cell Dormancy, Pirunthan Perampalam

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Disruption of Insertion Sequence 200 (IS200) leads to a premature induction of the Cysteine regulon in Salmonella Typhimurium, Naomi-Jean Q. Scherba

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A Characterization of RGNEF Biophysical Properties and Interactome, Brooke E. Wile

Theses/Dissertations from 2020

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Nutrient Sensing Pathways Mediating IGFBP1 Phosphorylation in FGR, Shapnil Bhuiyan

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The Genetic Determinants of Complex Lipid and Lipoprotein Phenotypes, Jacqueline S. Dron

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Development of a Thermosensitive Endonuclease to Act as a Plasmid Kill-Switch, Christopher D. Leichthammer

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AWT1 is Constantly Expressed in Palmar Fascia Fibrosis and Promotes a Pro-Inflammatory Milieu, Johnny Luo

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Practical Applications and Future Directions of Genetic Code Expansion: Validation of Novel Akt1 Substrates and the Design of a Synthetic Auxotroph Strain of B. subtilis, McShane M. McKenna

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Deciphering the CK2-dependent phosphoproteome and its integration with regulatory PTM networks, Teresa Nunez de Villavicencio Diaz

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Generation of Conditional Ku70 Knockouts in Human Cell Lines Using CRISPR/Cas9 and Dual-Nuclease CRISPR/TevCas9, Gursimran Parmar

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Thyroxine-Dependent and -Independent Effects on Premature Aging and Myelination in ATRX Mutant Mice, Megan E. Rowland

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Development of the Model Marine Diatom Phaeodactylum tricornutum for Synthetic Biology Applications, Samuel S. Slattery

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The role of Heat Shock Protein 90 in the Keap1/Nrf2 Mediated Oxidative-Stress Response, Zheng Song

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Structural Study of the Complex Between DNA Polymerase Iota and Ub-PCNA, Harrison Taylor

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Quinone Reductase 2 Roles in Proteomic Regulation and Response to Treatment with Clinical Drugs, Matthew D. Walker

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Calcium signaling and pathogenesis of dysferlin C2 domains, Yuning Wang

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Determining Whether the Nature of the Amino Acid Substitution or the Extent of Mistranslation Affects the Impact of Mistranslating tRNAs in Saccharomyces cerevisiae., Yanrui Zhu

Theses/Dissertations from 2019

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Placental MicroRNA Expression in Pregnancies Complicated with Preeclampsia and Intrauterine Growth Restriction, Zain Awamleh

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Differentially activating the oncogenic kinase Akt1, Nileeka Balasuriya

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Regulation of RNA stability by terminal nucleotidyltransferases, Christina Z. Chung

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The Characterization of the Rat Bone Sialoprotein Knockout Phenotype, Benjamin Harvey

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Improving the genetic diagnosis of familial hypercholesterolemia, Michael Iacocca

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High Molecular-Weight Hyaluronan Prevents Basal Cell Carcinoma Via Promoting Apoptosis In Cancer-Initiating Adult Stem Cells, Violet Liu

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Applications of Phosphotyrosine Superbinding SH2 Domain Variants, Xuguang Liu

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Functional investigation of the role of the retinoblastoma protein in genome stability, Aren E. Marshall

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Structure and Function of Stomatin-like Protein 2, Safee Mian

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Nobiletin Corrects Intestinal Insulin Resistance and Lipid Metabolism in Ldlr-/- Mice Fed a High-fat Diet, Nadya Morrow

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Systematic identification of the lysine methylome using methyllysine binding domains, Wen Qin

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Investigating the Role of ATRX in Glutamatergic Hippocampal Neurons, Renee Tamming

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Structural and Functional Characterization of Deinococcal DNA Damage Response A (DdrA), Filip Todorovic

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Parkin Structural Perturbations in Oxidative Stress, An Tran

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Mass Spectrometry-Based Proteomics Analysis Of Bioactive Proteins In EMD That Modulate Adhesion Of Gingival Fibroblast To Improve Bio-Integration Of Dental Implants, David Zuanazzi Machado Jr

Theses/Dissertations from 2018

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Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin, Amy C. Burke

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Regulation of Beta-Catenin by the CTLH Complex, Christopher Chiasson

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Conformational Arrangements of UbcH7-Ubiquitin with OspG and Parkin, Tara E. C. Condos

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Chromatin organizer CTCF in brain development and behaviour, Adrienne Elbert

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Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo, Mohammad Haider Hassan

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Genetic determinants underlying rare diseases identified using next-generation sequencing technologies, Rosettia Ho

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The Role of Thymine-DNA Glycosylase In Transcriptional Regulation, Bart Kolendowski

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Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR), Bethany N. Radford

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The Functional Characterization of the N-terminal Domains of TUT4, Lauren E. Seidl

Theses/Dissertations from 2017

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Autoinhibition and Activation of Parkin, Jacob D. Aguirre

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Characterizing the Cofactor Specificity of NQO2, Shahed Al Massri

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Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation, Katelyn Cousteils

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An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha, Edward Cruise

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Identification of novel binding partners and substrates of histone H3K4 specific demethylase KDM5B/JARID1B, Qi Fang

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Effect on Pellicle Proteome upon Adsorption of Salivary Peptide on Hydroxyapatite and their effects on Enamel Demineralization, Rajesh Kr. Gupta

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Tti2 in PIKK Biosynthesis and Its Use in Identifying Missense Suppressor tRNAs, Kyle S. Hoffman

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The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences, Charles A. Ishak

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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration, Miljan Kuljanin

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Coevolving Residues and the Expansion of Substrate Permissibility in LAGLIDADG Homing Endonucleases, Thomas A. McMurrough

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Regulation of C-RAF stability by the RanBPM/CTLH complex, Christina J. McTavish

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Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2, Adam J. Rabalski

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Investigating E2F independent cell cycle control and tumor suppression by pRB, Michael J. Thwaites

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An invasive tumor cell subpopulation as a therapeutic target in breast cancer, Tahereh Vakili

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Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response, Elizabeth A. Walden

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Structural and Functional Characterization of Non-Homologous End Joining Factors, Huasheng Wang

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Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity, Alanna R. Watson

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Dual-active genome-editing reagents, Jason M. Wolfs

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Investigation of the Interactions between Elg1 and PCNA Involved in the DNA Damage Response, Jingwei Yan

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Investigating the Regulatory Circuitry of Protein Kinases and Proteases in Apoptosis, Stephanie A. Zukowski

Theses/Dissertations from 2016

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Structure and Function Relationships between ATPase Family, AAA Domain Containing Protein 5, Proliferating Cell Nuclear Antigen, and USP1-Associated Factor 1, Tam T. Bui

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Investigating the Role of Extracellular Matrix Proteins in Ovarian Folliculogenesis and Ovarian Cancer, Alexandra Carrier

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Characterization of the catalytic CK2 subunits with substitutions at residues involved in inhibitor binding, Paul Desormeaux

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Assessing the role of the ATRX chromatin remodeling protein in myelination within the mouse central nervous system, Matthew W. Edwards

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Riboregulation of Bacterial Transposons, Michael J. Ellis

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Gene Discovery in Mendelian and Complex Diseases, Sali Farhan

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Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants, Susanna George

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Interaction of SecA with Unfolded Polypeptides, Aliakbar Khalili Yazdi

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Insights into Chibby's structural elements and their interplay in Wnt signaling protein-protein interactions, Ryan C Killoran

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Using mutual information to reprogram DNA specificity of LAGLIDADG endonucleases, Marcon Laforet

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The Role of Sirtuin 6 in Maintaining Vascular Integrity, Sharon Z. Leung

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Structural Analysis of TPR Ligand Complexes of STIP1 Implicated in Alzheimer's Disease, Andrzej Maciejewski

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Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease, Alexander S. McCarton

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Examining the role of ATRX in astrocytes, Haley McConkey

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Nucleoporin-mediated regulation of the Kcnq1ot1 imprinted domain, Saqib Sachani