Biochemistry Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2018

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Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin, Amy C. Burke

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Regulation of Beta-Catenin by the CTLH Complex, Christopher Chiasson

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Conformational Arrangements of UbcH7-Ubiquitin with OspG and Parkin, Tara E. C. Condos

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Chromatin organizer CTCF in brain development and behaviour, Adrienne Elbert

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Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo, Mohammad Haider Hassan

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Genetic determinants underlying rare diseases identified using next-generation sequencing technologies, Rosettia Ho

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The Role of Thymine-DNA Glycosylase In Transcriptional Regulation, Bart Kolendowski

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The Functional Characterization of the N-terminal Domains of TUT4, Lauren E. Seidl

Theses/Dissertations from 2017

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Autoinhibition and Activation of Parkin, Jacob D. Aguirre

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Characterizing the Cofactor Specificity of NQO2, Shahed Al Massri

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Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation, Katelyn Cousteils

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An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha, Edward Cruise

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Identification of novel binding partners and substrates of histone H3K4 specific demethylase KDM5B/JARID1B, Qi Fang

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Effect on Pellicle Proteome upon Adsorption of Salivary Peptide on Hydroxyapatite and their effects on Enamel Demineralization, Rajesh Kr. Gupta

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Tti2 in PIKK Biosynthesis and Its Use in Identifying Missense Suppressor tRNAs, Kyle S. Hoffman

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The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences, Charles A. Ishak

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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration, Miljan Kuljanin

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Coevolving Residues and the Expansion of Substrate Permissibility in LAGLIDADG Homing Endonucleases, Thomas A. McMurrough

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Regulation of C-RAF stability by the RanBPM/CTLH complex, Christina J. McTavish

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Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2, Adam J. Rabalski

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Investigating E2F independent cell cycle control and tumor suppression by pRB, Michael J. Thwaites

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An invasive tumor cell subpopulation as a therapeutic target in breast cancer, Tahereh Vakili

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Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response, Elizabeth A. Walden

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Structural and Functional Characterization of Non-Homologous End Joining Factors, Huasheng Wang

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Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity, Alanna R. Watson

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Dual-active genome-editing reagents, Jason M. Wolfs

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Investigation of the Interactions between Elg1 and PCNA Involved in the DNA Damage Response, Jingwei Yan

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Investigating the Regulatory Circuitry of Protein Kinases and Proteases in Apoptosis, Stephanie A. Zukowski

Theses/Dissertations from 2016

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Structure and Function Relationships between ATPase Family, AAA Domain Containing Protein 5, Proliferating Cell Nuclear Antigen, and USP1-Associated Factor 1, Tam T. Bui

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Investigating the Role of Extracellular Matrix Proteins in Ovarian Folliculogenesis and Ovarian Cancer, Alexandra Carrier

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Characterization of the catalytic CK2 subunits with substitutions at residues involved in inhibitor binding, Paul Desormeaux

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Assessing the role of the ATRX chromatin remodeling protein in myelination within the mouse central nervous system, Matthew W. Edwards

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Riboregulation of Bacterial Transposons, Michael J. Ellis

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Gene Discovery in Mendelian and Complex Diseases, Sali Farhan

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Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants, Susanna George

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Interaction of SecA with Unfolded Polypeptides, Aliakbar Khalili Yazdi

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Insights into Chibby's structural elements and their interplay in Wnt signaling protein-protein interactions, Ryan C Killoran

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Using mutual information to reprogram DNA specificity of LAGLIDADG endonucleases, Marcon Laforet

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The Role of Sirtuin 6 in Maintaining Vascular Integrity, Sharon Z. Leung

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Structural Analysis of TPR Ligand Complexes of STIP1 Implicated in Alzheimer's Disease, Andrzej Maciejewski

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Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease, Alexander S. McCarton

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Examining the role of ATRX in astrocytes, Haley McConkey

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Nucleoporin-mediated regulation of the Kcnq1ot1 imprinted domain, Saqib Sachani

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Characterization of RanBPM Subcellular Localization and Function in HDAC6 Regulation, Louisa M. Salemi

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Prevention of Murine Atherosclerosis with Bempedoic Acid, Joshua P. Samsoondar

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Characterization of NUMB as a Regulator of Anaplastic Lymphoma Kinase, Ran Wei

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Assisted Reproductive Technologies Disrupt Genomic Imprinting in Human and Mitochondria in Mouse Embryos, Carlee R. White

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Measuring the human gut microbiome: new tools and non alcoholic fatty liver disease, Ruth G. Wong

Theses/Dissertations from 2015

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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation, Adrian Buensuceso

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A Unified Framework for the Prioritization of Variants of Uncertain Significance in Hereditary Breast and Ovarian Cancer Patients, Natasha G. Caminsky

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Interpretation of Mutations, Expression, Copy Number in Somatic Breast Cancer: Implications for Metastasis and Chemotherapy, Stephanie Dorman

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Investigating the Binding of Peptidyl-Prolyl Isomerase Pin1 to a Multi-Site Phosphorylated Substrate Modeled After Phosphatase CDC25C, Michelle K. Dubinsky

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Interdomain interactions of the transactive response DNA binding protein 43 kDa (TDP-43), Karen M. Dunkerley

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The Rational Design and Evaluation of CK2alpha Mutants Bearing Inhibitor-Refractory Amino Acid Substitutions, Sam Reid Fess

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Chemical Biology Approaches to Investigate the Activity and Substrate Specificity of Protein Kinase CK2, Michelle A. Gabriel

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Translesion synthesis and mutations: On the mutagenic properties of the two DNA lesions, 8-oxo-G and Pt-GG, and the functions of Y-family DNA polymerases and Rev3L on the bypass of each of the DNA lesions in mammalian cells, Lizhen Guo

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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage, Krista M. Hawrylyshyn

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Characterizing the Function of Helix Five of the Ku70 von Willebrand A Domain in Non-Homologous End Joining, Sarah M. Hoffer

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Quinone Reductase 2 is a Flavin Redox Switch, Kevin Ka Ki Leung

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The role of thymine DNA glycosylase (TDG) and DNA demethylation in TGF beta signaling, Matthew E.R. Maitland

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Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation to IGFBP-1 Hyperphosphorylation in Fetal Growth Restriction, Niyati M. Malkani

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The role of bone sialoprotein in the tendon-bone insertion, Ryan M. Marinovich

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Examining the Nucleotide Preference of the Linker Domain in Engineered Tev-mTALENs, Brendon C. McDowell

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Investigating the role of the extracellular matrix protein, Spondin 1, in ovarian folliculogenesis, Caitlin O'Flynn

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Isolation and Characterisation of Relaxed Specificity I-TevI Nuclease Domain Mutants, Alexander C. Roy

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The Epigenetic Regulators ATRX and CTCF are Required for Mouse Neuroprogenitor Cell Survival and Brain Development, Lauren Ashley Watson

Theses/Dissertations from 2014

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Investigating the Role of Retinoblastoma Protein and Transforming Growth Factor-Beta in Growth Inhibition, Mehdi Amiri

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Characterizing the interaction between RanBPM and c-Raf, Wesley Berube-Janzen

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The role of the arginine methyltransferase CARM1 in global transcriptional regulation., Niamh Coughlan

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The Roles of Matrix-Associated Periostin in an In Vitro Model of Hypertrophic Scarring, Justin D. Crawford

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Regulation of IGFBP-1 Phosphorylation in Hypoxia Via mTOR Signaling, Ian Damerill

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Maternal Control of Genomic Imprinting: Effects of Infertility and Ovarian Stimulation in a Mouse Model, Michelle M. Denomme

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Regulation of SAGA by the N-terminus of Spt7 in Saccharomyces cerevisiae, Dominik Dobransky

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The Effects of RHAMM on Cell Division, Cell Motility, and Tumorigenesis, Sallie Elhayek

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The Role of the Ku70 vWA Domain in the Response to DNA Double Strand Breaks, Victoria L. Fell

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Bone Sialoprotein and Osteopontin Mediate Bone Development, Erik Martin Holm

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Targeted Proteomics of Human Pluripotent Stem Cells, Kevin Gregory Kania

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Mechanistics of Prothymosin alpha and Nrf2 in the Keap1-Nrf2 mediated Oxidative Stress Response, Halema Khan

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The Role of the Pre-Sensor 1 β Hairpin in Minichromosome Maintenance 2-7 Function, Simon K. W. Lam

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Regulation of the Kcnq1ot1 Imprinting Domain in Mouse, Lauren SM Landschoot

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Characterization of the anti-apoptotic function of the lysine demethylase plant homeodomain finger protein 8 (PHF8), Kimberly Muranko

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Characterizing the domain- and phosphorylation-requirements of the interaction between peptidyl prolyl isomerase Pin1 and mitotic phosphatase CDC25C, Dana Onica

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Investigation of β-Catenin-Mediated Regulation of IGFBP-6 and the Roles of IGFBP-6 and IGF-II in Dupuytren's Disease, Christina N. Raykha

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Host-imposed regulation of bacterial transposons Tn10 and Tn5, Joseph A. Ross

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Post-Translational Control of Retinoblastoma Protein Phosphorylation, Paul M. Stafford

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The Role of Oxygen Tension and Insulin-Like Growth Factor Signaling in the Placental Mesenchymal Stem Cell Fate, Amer Youssef

Theses/Dissertations from 2013

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Resolving the Genetic Etiology of Hypercholesterolemia in Familial Combined Hyperlipidemia, Mary A. Bamimore

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Regulation of Lipid Homeostasis, Inflammatory Signalling and Atherosclerosis by the Peroxisome Proliferator-Activated Receptor Delta, Lazar A. Bojic

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Features of Dormancy in Metastatic Ovarian Cancer Cells, Rohann JM Correa

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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression, Courtney H. Coschi

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Regulation of eukaryotic Mcm2-7 activity, Lance F. DaSilva

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Computational Molecular Coevolution, Russell J. Dickson

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Detection, prioritization and analysis of variants of unknown significance in familial breast cancer genes, Eddie A. Dovigi

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Genetic approaches to studying complex human disease, Joseph B. Dube

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Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1, Brendan T. Innes

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DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases, Benjamin P. Kleinstiver

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Characterizing the human vaginal microbiome using high-throughput sequencing, Jean Megan E. Macklaim

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Structure of C-terminal Domain of Parkin, IBR-RING2, Yeong Ju Noh

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Insights into the Function of the FATC Domain of Saccharomyces Cervisiae TRA1 via Mutation and Suppressor Analysis, Samantha A. Pillon

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The Chromatin Remodeling Protein ATRX in Development and Maintenance of Mouse Skeletal Tissues, Lauren A. Solomon