Medical Biophysics Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Medical Biophysics, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2022

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Quantitative Assessment of Cardiac Functional Response after External Beam Radiotherapy using Non-invasive Multi-Modality Imaging, Oi Wai Chau, Doctor of Philosophy, Supervisor: Gaede, Stewart

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Delineation of Ascending Aortic Medial Degeneration using Diffusion Tensor Imaging, Justin A. Ching-Johnson, Master of Science, Supervisor: Pickering, Geoffrey J.

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Cost-effective non-destructive testing of biomedical components fabricated using additive manufacturing, Santiago Fabian Cobos, Doctor of Philosophy, Supervisor: Holdsworth, David W.

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Quantitative MRI and 3D-Printing for Monitoring Periprosthetic Joint Infection, Greg Hong, Doctor of Philosophy, Supervisor: Drangova, Maria

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Atrial Fibrillation and Cognitive Decline: a Computational Hemodynamics Investigation, Timothy J. Hunter, Master of Science, Supervisor: Goldman, Daniel

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Exploration of the pathophysiological mechanisms underlying hemodialysis associated cardiac ischemic injury, Lisa Yun Jeong Hur, Doctor of Philosophy, Supervisor: McIntyre, Christopher W.

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Multi-scale computational modeling of coronary blood flow: application to fractional flow reserve., Jermiah Joseph, Master of Science, Supervisor: McIntyre, Christopher W.

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An in vivo investigation of short-ranged structural connectivity in the human brain, Jason Kai, Doctor of Philosophy, Supervisor: Khan, Ali R.

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Magnetic Resonance Systems Development for Point-of-Care MRI Platforms, Eric J. Lessard, Doctor of Philosophy, Supervisor: Chronik, Blaine A

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Technical Adaptations for Cardiac Sodium MRI, Taylor L. Marcus, Master of Science, Supervisor: McIntyre, Christopher

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Applications of Gradient Representations in Resting-State fMRI, Geoffrey Ngo, Doctor of Philosophy, Supervisor: Menon, Ravi S.

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A Fast Voxel-based 3D Dose Convolution Method for Personalized Targeted Radionuclide Therapy of Prostate Cancer Patients, Chidera Opara, Master of Science, Supervisor: Lee, Ting Yim

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Software and Hardware-based Tools for Improving Ultrasound Guided Prostate Brachytherapy, Nathan Orlando, Doctor of Philosophy, Supervisor: Fenster, Aaron

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Investigating tumor perfusion, glycolysis and pH environments with multimodal in vivo imaging, Qi Qi, Doctor of Philosophy, Supervisor: Thiessen, Jonathan D.

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Targeting Prostate Cancer through High Dose Rate Brachytherapy, Christopher Smith, Doctor of Philosophy, Supervisor: Dr. Aaron Ward

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Activatable synthetic biomarker systems for gene- and cell-based cancer detection and theranostics, TianDuo Wang, Doctor of Philosophy, Supervisor: Ronald, John A.

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Characterizing The Transcriptome of Sirt6-Deficient Aortic Smooth Muscle Cells, Ryan J. Wong, Master of Science, Supervisor: Dr. J. Geoffrey Pickering

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Development of a Near-Full-View Angle Coverage Photoacoustic Tomography System and Its Application Towards Optical Fluence Distribution Imaging, Lawrence CM Yip, Doctor of Philosophy, Supervisor: Carson, Jeffrey J.L.

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Anatomical and Functional Lung Imaging with Volumetric Computed Tomography in Non-Small Cell Lung Cancer, Heather Young, Doctor of Philosophy, Supervisor: Gaede, Stewart

Theses/Dissertations from 2021

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Computer-assisted lesion classification and intervention planning for prostate cancer, Ryan M. Alfano, Doctor of Philosophy, Supervisor: Ward, Aaron D.

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Frequency dependent diffusion kurtosis measurement in the human brain with oscillating gradients, Kevin B. Borsos, Master of Science, Supervisor: Baron, Corey A.

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Investigating a Novel Receptor that Mediates Vasoconstriction in Mouse Femoral Arteries, Joselia Carlos, Master of Science, Supervisor: McGuire, John

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Ischemic Stroke Thrombus Characterization through Quantitative Magnetic Resonance Imaging, Spencer D. Christiansen, Doctor of Philosophy, Supervisor: Drangova, Maria

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Rapid Recovery Of Cerebral Blood Content And Oxygenation In Adults From Time-Resolved Near-Infrared Spectroscopy, David J. F. Cohen, Master of Science, Supervisor: Diop, Mamadou

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In Vivo Detection of CAR-T cell Immunotherapy using 3 Tesla Fluorine-19 MRI, Veronica Dubois, Master of Science, Supervisor: Ronald, John A.

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A quantitative assessment of hemodynamic and histological parameters in the mdx mouse model, Sarah Hakim, Master of Science, Supervisor: Hoffman, Lisa M.

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Investigating Bone Cement Susceptibility Related Artifacts and Adhesion, Eric Kuindersma, Master of Science, Supervisor: Ravi Menon

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Delineating the Skeletal Muscle-Microvessel Regeneration Program after Ischemic Injury, Jason J. Lee, Doctor of Philosophy, Supervisor: Pickering, J. Geoffrey

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Using Hyperspectral Near-Infrared Spectroscopy and Diffuse Correlation Spectroscopy to Monitor the Effects of Phenylephrine in the Microcirculation, Laura Mawdsley, Master of Science, Supervisor: Ellis, Christopher G.

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Experimental, theoretical, and translational studies of RBC distribution in capillary networks, Asher Mendelson, Doctor of Philosophy, Supervisor: Ellis, Christopher G

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Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis, David C.R. Michels, Master of Science, Supervisor: Singh, Krishna K.

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Non-invasive quantification of cerebral oxygen metabolism by hybrid positron emission tomography/magnetic resonance imaging, Lucas Diovani Lopes Narciso, Doctor of Philosophy, Supervisor: St Lawrence, Keith

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Three-dimensional Ultrasound Imaging For Quantifying Knee Cartilage Volume, Samuel Papernick, Master of Science, Supervisor: Fenster, Aaron

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NNeMo (Neonatal NeuroMonitor) - a hybrid optical system to characterize perfusion and metabolism in the newborn brain, Ajay Rajaram, Doctor of Philosophy, Supervisor: Keith St. Lawrence

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MRI of structural & functional changes associated with Western diet consumption, Lauren M. Smith, Doctor of Philosophy, Supervisor: McKenzie, Charles A.

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Validation of Arterial Spin Labeling for Longitudinal Monitoring and Differential Diagnosis of Frontotemporal Dementia, Tracy Ssali, Doctor of Philosophy, Supervisor: Keith St Lawrence

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Phase imaging for reducing macrovascular signal contributions in high-resolution fMRI, Olivia W. Stanley, Doctor of Philosophy, Supervisor: Menon, Ravi S

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Endothelial Dysfunction in Hindlimb Arteries of Old Sprague Dawley rats, and the Type 2 Diabetic Zucker Diabetic Sprague Dawley strain., Andrea N. Wang, Master of Science, Supervisor: McGuire, John J.

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Developing sodium MRI for longitudinal assessment of chemotherapy of glioma in a rat model of cancer, Xin Yue Wang, Master of Science, Supervisor: Scholl, Timothy J.

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Measuring inflammation in the entire myocardium in a canine model of myocardial infarction with hybrid PET/MRI, Benjamin Wilk, Doctor of Philosophy, Supervisor: Prato, Frank S.

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Exploring Multimodal Cancer Cell Tracking Using Magnetic Particle Imaging and Akaluc BLI, Ryan J. Williams, Master of Science, Supervisor: Ronald, John A

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Laparoscopic Image Recovery and Stereo Matching, Wenyao Xia, Doctor of Philosophy, Supervisor: Terry Peters M.

Theses/Dissertations from 2020

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Detecting Command-Driven Brain Activity in Patients with Disorders of Consciousness Using TR-fNIRS, Androu Abdalmalak, Doctor of Philosophy, Supervisor: St. Lawrence, Keith

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TSPO PET Detects Acute Neuroinflammation but not Diffuse Chronically Activated MHCII Microglia in the Rat, Nassir Al-Khishman, Master of Science, Supervisor: Thiessen, Jonathan D.

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Multimodality imaging to quantify the pulmonary vascular tree in COPD, Andrea L. Barker Odhiambo, Master of Science, Supervisor: Parraga, Grace

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Impact of Graded Passive Cycling on Hemodynamics, Cerebral Blood Flow, and Heart Function in Healthy Adults and Septic ICU Patients, Jennifer Chen, Master of Science, Supervisor: McIntyre, Christopher W

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Lanthanide Nanoparticles as Contrast Agents for In Vivo Dual Energy Microcomputed Tomography of the Mouse Vasculature, Charmainne Cruje, Doctor of Philosophy, Supervisor: Drangova, Maria

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Structure and Function of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy, Doctor of Philosophy, Supervisor: Parraga, Grace

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Quantifying Mid-pregnancy Placental Metabolism in Guinea Pigs Fed a Lifelong Western Diet, Mary-Ellen E.T Empey, Master of Science, Supervisor: McKenzie, Charles A.

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Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient, Adam Helmy Farag, Doctor of Philosophy, Supervisor: Jean Théberge

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A Novel System and Image Processing for Improving 3D Ultrasound-guided Interventional Cancer Procedures, Derek J. Gillies, Doctor of Philosophy, Supervisor: Fenster, Aaron

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Metabolic Syndrome Impairs Cerebrovascular Tone and Behaviour in Obese Zucker Rats, Brayden D. Halvorson, Master of Science, Supervisor: Frisbee, Jefferson C.

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Chronic Neurological Impairment in Patients with Thrombotic Thrombocytopenic Purpura: Findings in Quantitative MRI, Jeffrey Hamilton, Master of Science, Supervisor: Huang, Susan S.H.

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Machine Learning for Prostate Histopathology Assessment, Wenchao Han, Doctor of Philosophy, Supervisor: Ward, Aaron D.

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Force Application During Colonoscopy as a Marker of Competence: Development of a Novel Training Device, Jeffrey D. Hawel, Master of Science, Supervisor: Patel, Rajni

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Cancer Detection in Radical Prostatectomy Histology using Convolutional Neural Networks, Laurie Huang, Master of Science, Supervisor: Ward, Aaron D.

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Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection, Tina Khazaee, Master of Science, Supervisor: David W. Holdsworth

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Kinetic Analysis of Dynamic PET for Molecular, Functional and Physiological Characterization of Diseases, Fiona Li, Doctor of Philosophy, Supervisor: Lee, Ting-Yim

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Exploring the Effects of Hemodialysis on Renal and Hepatic Blood Flow and Function using CT Perfusion Imaging, Raanan Marants, Doctor of Philosophy, Supervisor: Lee, Ting-Yim

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Neurite Orientation Dispersion and Density Imaging in a Rodent Model of Mild Traumatic Brain Injury, Patrick McCunn, Doctor of Philosophy, Supervisor: Bartha, Robert

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Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres, Kierstin P. Melo, Master of Science, Supervisor: Foster, Paula

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A Genetically-Encoded Reporter for In Vivo Imaging in Deep Tissues, Nivin N. Nasri, Doctor of Philosophy, Supervisor: Scholl, Timothy J.

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A Clinically Representative Rat Model of Hip Hemiarthroplasty, Adam DM Paish, Doctor of Philosophy, Supervisor: Holdsworth, David W

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A Hybrid PET/MRI Brain Connectivity Approach for Improving Epilepsy Surgical Evaluation, Stefan E. Poirier, Master of Science, Supervisor: Anazodo, Udunna C.

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A 3D Microvessel Model for the Study of Endothelial Cell Transluminal Pillar Formation, Emma Kate Prescott, Master of Science, Supervisor: Pickering, J. Geoffrey

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Tissue Sodium in CKD Patients, Elena Qirjazi, Master of Science, Supervisor: Christopher McIntyre

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Hybrid Optical System for Studying the Dynamic Regulation of Blood Flow/Metabolism in the Adult Brain, Marwan Shahid, Master of Science, Supervisor: StLawrence, Keith

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Neurocognitive impairment across the continuum of critical illness: exploration of acute insults, functional risk factors, and clinical monitoring tools., Marat Slessarev, Doctor of Philosophy, Supervisor: Ellis, Christopher

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An approach for the in-vivo characterization of brain and heart inflammation in Duchenne Muscular Dystrophy, Joanne Tang, Master of Science, Supervisor: Anazodo, Udunna C.

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Quantitative Dynamic PET & CT Perfusion for Cancer Imaging: Diagnosis & Monitoring Treatment Response, Dae-Myoung (Danny) Yang, Doctor of Philosophy, Supervisor: Lee, Ting-Yim

Theses/Dissertations from 2019

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Analyzing myocardial R2* mapping pre- and post-myocardial infarction in a canine model, Khalid Abdalla, Master of Science, Supervisor: Dr. Donna Goldhawk

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Schrödinger Filtering: A Novel Technique for Removing Gradient Artifact from Electroencephalography Data Acquired during Functional Magnetic Resonance Imaging, Gabriel Bruno Benigno, Master of Science, Supervisor: Menon, Ravi S.

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Microvascular Stenosis in Critical Limb Ischemia: Role of Partial Endothelial to Mesenchymal Transition, Jacqueline M. Chevalier, Master of Science, Supervisor: Pickering, J. G.

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Monocyte MRI Relaxation Rates are Regulated by Extracellular Iron and Hepcidin, Praveen S.B Dassanayake, Master of Science, Supervisor: Goldhawk, Donna

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Development of a Computational Method for Assessing Static Field Induced Torque on Medical Implants, Xiao Fan Ding, Master of Science, Supervisor: Chronik, Blaine A.

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Piezo1: Proteins for mechanotransduction and integration of endothelial shear stress & intravascular pressure, Juan Garcia Robledo M.D., Master of Science, Supervisor: Dr. Dwayne Jackson

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Functional Magnetic Resonance Spectroscopy in First-Episode Schizophrenia: Measuring Glutamate and Glutathione Dynamics at 7-Tesla, Peter Jeon, Master of Science, Supervisor: Theberge, Jean

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Towards on-line plan adaptation of unified intensity-modulated arc therapy using a fast-direct aperture optimization algorithm, Michael MacFarlane, Doctor of Philosophy, Supervisor: Chen, Jeff Z.

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Neoadjuvant Stereotactic Ablative Radiotherapy To Treat Early Stage Breast Cancer Patients: The Role Of DCE-MRI, Matthew Mouawad, Doctor of Philosophy, Supervisor: Gaede, Stewart

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An apodized-aperture x-ray detector design for improved image quality in mammography, Tomi F. Nano, Doctor of Philosophy, Supervisor: Cunningham, Ian A.

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Investigating the Mechanisms of Breast Cancer Metastasis Using Multimodality Molecular Imaging, Katie Parkins, Doctor of Philosophy, Supervisor: Foster, Paula J.

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Clinical application of 3D ultrasound in neonatal intraventricular hemorrhage, Priyanka Roy, Master of Science, Supervisor: de Ribaupierre, Sandrine

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Investigating in vivo Brain Metabolite Levels in Concussed Female Athletes and a Murine Model of Repetitive Closed Head Injury, Amy L. Schranz, Doctor of Philosophy, Supervisor: Bartha, Robert

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Texture Analysis and Machine Learning to Predict Pulmonary Ventilation from Thoracic Computed Tomography, Andrew Westcott, Master of Science, Supervisor: Parraga, Grace

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Assessing the Impact of Surgical Technique on Implant Migration, Tibiofemoral Contact Kinematics, and Functional Recovery Following Uncemented Total Knee Arthroplasty, Harley A. Williams, Master of Science, Supervisor: Teeter, Matthew G.

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MRI Investigations of Metabolic and Structural Brain Changes in Alzheimer’s Disease and Vitamin D Deprivation, Dickson Wong, Doctor of Philosophy, Supervisor: Bartha, Robert

Theses/Dissertations from 2018

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7T Magnetic Resonance Spectroscopy of Non-Lesional Temporal Lobe Epilepsy, John Robert Adams, Master of Science, Supervisor: Bartha, Robert

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Acute Pharmacologic Modulation of Glioblastoma pH Monitored by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Mohammed Albatany, Doctor of Philosophy, Supervisor: Bartha, Robert

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Quantitative Analysis of Three-Dimensional Cone-Beam Computed Tomography Using Image Quality Phantoms, Rudy Baronette, Master of Science, Supervisor: Holdsworth, David W.

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Characterization of Human Prostate Cancer Using Sodium Magnetic Resonance Imaging, Nolan Christopher Broeke, Master of Science, Supervisor: Scholl, Timothy J

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Imaging Biomarkers of Pulmonary Structure and Function, Dante Capaldi, Doctor of Philosophy, Supervisor: Dr. Grace Parraga

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High Performance Optical Computed Tomography for Accurate Three-Dimensional Radiation Dosimetry, Kurtis Hendrik Dekker, Doctor of Philosophy, Supervisor: Jordan, Kevin J.

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An Integrated Approach to Analyzing Arteriolar Network Hemodynamics., Zahra Farid, Master of Science, Supervisor: Jackson, Dwayne N.

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Wearable sensors and total knee arthroplasty: Assessing quantitative function to improve the patient experience, Megan Fennema, Master of Science, Supervisor: Teeter, Matthew G.

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Functional CT Imaging for Myocardial Salvage in Acute Myocardial Infarction Management, Lisa Yun Jeong Hur, Master of Science, Supervisor: Drangova, Maria

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Retrospective Motion Correction in Magnetic Resonance Imaging of the Brain, Patricia Johnson, Doctor of Philosophy, Supervisor: Drangova, Maria

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Validation of a Hyperspectral NIRS Method for Measuring Tissue Oxygen Saturation, Matthew Kewin, Master of Science, Supervisor: St Lawrence, Keith

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Development and validation of a stand-alone DCS system for monitoring absolute cerebral blood flow., Mahro Khalid, Master of Science, Supervisor: St. Lawrence, Keith

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Multi-Scale Peripheral Vasculopathy with Metabolic Syndrome, Kent Lemaster, Doctor of Philosophy, Supervisor: Jefferson C. Frisbee

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In Vivo Tracking of Tumour Associated Macrophages in Breast Cancer with Magnetic Resonance Imaging, Ashley V. Makela, Doctor of Philosophy, Supervisor: Foster, Paula J