Medical Biophysics Theses and Dissertations
This collection contains theses and dissertations from the Department of Medical Biophysics, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2023
Evaluating the Biomechanical, Functional, and Clinical Outcomes of Bicruciate Stabilized Total Knee Arthroplasty, Jordan S. Broberg, Doctor of Philosophy, Supervisor: Teeter, Matthew G.
Investigating the role of miRNA-378-3p and its target PDIA-4 in endothelial cells, Shuhan Bu, Master of Science, Supervisor: Singh, Krishna K
Improving the Reliability and Accessibility of CT Perfusion Imaging in Acute Ischemic Stroke, Kevin J. Chung, Doctor of Philosophy, Supervisor: Lee, Ting-Yim
Development of Magnetic Particle Imaging for Quantitative Immune Cell Tracking, Julia J. Gevaert, Doctor of Philosophy, Supervisor: Foster, Paula J.
Spatiotemporal Optimization of Intratumoural Electric Field Modulation for Cancer Therapy, Erin Iredale, Doctor of Philosophy, Supervisor: Wong, Eugene
Investigating Cellular Imaging Techniques for Cancer Cell Tracking, Natasha Knier, Doctor of Philosophy, Supervisor: Foster, Paula J.
Assessing Inflammation in the Pathology of Knee Osteoarthritis, Zachary J. Koudys, Master of Science, Supervisor: Teeter, Matthew G.
Depth-Dependent Analysis of Human Ocular Dominance Columns using fMRI with Phase Regression, Brett T. Liem, Master of Science, Supervisor: Menon, Ravi S.
Novel 129Xe Magnetic Resonance Imaging and Spectroscopy Measurements of Pulmonary Gas-Exchange, Alexander M. Matheson, Doctor of Philosophy, Supervisor: Parraga, Grace E.
Characterization of the DMD mouse's dynamic skeletal muscle microvascular niche, Andrew McClennan, Master of Science, Supervisor: Hoffman, Lisa
The Development and Application of a Novel Index for Assessing Vascular Health Status, Nithin J. Menon, Master of Science, Supervisor: Frisbee, Jefferson C
The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers, Mehrshad Moradshahi, Master of Science, Supervisor: McIntyre, Christopher
Microvascular Responsiveness to Cardiopulmonary Bypass, Michael O'Neil, Doctor of Philosophy, Supervisor: Ellis, Christopher G
Exploring Novel Intradialytic Techniques to Identify & Ameliorate of Hemodialysis-induced Myocardial Ischemic Injury, Jarrin D. Penny, Doctor of Philosophy, Supervisor: McIntyre, CW
An Evaluation of a Deep learning approach for Radiation Dose Reduction in 18F-FDG PET/MRI Pediatric Epilepsy Imaging, Confidence Raymond, Master of Science, Supervisor: Anazodo Udunna
Advancing non-invasive imaging techniques for tracking cellular therapeutics in vivo, Olivia C. Sehl, Doctor of Philosophy, Supervisor: Foster, Paula J.
In vivo multi-modal imaging approaches for cancer, stem and immune cells, Nourhan Shalaby, Doctor of Philosophy, Supervisor: Scholl, Timothy J.
Building a Magnetosome-like Nanoparticle for Magnetic Resonance Imaging, Qin Sun, Doctor of Philosophy, Supervisor: Goldhawk, Donna E.
Longitudinal Computed Tomography Airway Measurements in Ex-Smokers with and without Chronic Obstructive Pulmonary Disease, Paulina V. Wyszkiewicz, Master of Science, Supervisor: Parraga, Grace
Radiomics to Predict Local Progression of Non-Spine Bone Metastases Following Stereotactic Radiotherapy, Lauren M. Zelko, Master of Science, Supervisor: Mattonen, Sarah A.
Theses/Dissertations from 2022
Quantitative Assessment of Cardiac Functional Response after External Beam Radiotherapy using Non-invasive Multi-Modality Imaging, Oi Wai Chau, Doctor of Philosophy, Supervisor: Gaede, Stewart
Delineation of Ascending Aortic Medial Degeneration using Diffusion Tensor Imaging, Justin A. Ching-Johnson, Master of Science, Supervisor: Pickering, Geoffrey J.
Cost-effective non-destructive testing of biomedical components fabricated using additive manufacturing, Santiago Fabian Cobos, Doctor of Philosophy, Supervisor: Holdsworth, David W.
Examining the Association between Brain MRI Measures at 7 Tesla and cognition following COVID-19 Infection, Helma Heidari, Master of Science, Supervisor: Dr. Robert Bartha
Quantitative MRI and 3D-Printing for Monitoring Periprosthetic Joint Infection, Greg Hong, Doctor of Philosophy, Supervisor: Drangova, Maria
Atrial Fibrillation and Cognitive Decline: a Computational Hemodynamics Investigation, Timothy J. Hunter, Master of Science, Supervisor: Goldman, Daniel
Exploration of the pathophysiological mechanisms underlying hemodialysis associated cardiac ischemic injury, Lisa Yun Jeong Hur, Doctor of Philosophy, Supervisor: McIntyre, Christopher W.
Multi-scale computational modeling of coronary blood flow: application to fractional flow reserve., Jermiah Joseph, Master of Science, Supervisor: McIntyre, Christopher W.
An in vivo investigation of short-ranged structural connectivity in the human brain, Jason Kai, Doctor of Philosophy, Supervisor: Khan, Ali R.
Magnetic Resonance Systems Development for Point-of-Care MRI Platforms, Eric J. Lessard, Doctor of Philosophy, Supervisor: Chronik, Blaine A
Simulated and experimental approaches to the development of novel test phantoms for radiofrequency heating of implanted medical devices, Amgad M. Louka, Doctor of Philosophy, Supervisor: Chronik, Blaine A.
Technical Adaptations for Cardiac Sodium MRI, Taylor L. Marcus, Master of Science, Supervisor: McIntyre, Christopher
Applications of Gradient Representations in Resting-State fMRI, Geoffrey Ngo, Doctor of Philosophy, Supervisor: Menon, Ravi S.
A Fast Voxel-based 3D Dose Convolution Method for Personalized Targeted Radionuclide Therapy of Prostate Cancer Patients, Chidera Opara, Master of Science, Supervisor: Lee, Ting Yim
Software and Hardware-based Tools for Improving Ultrasound Guided Prostate Brachytherapy, Nathan Orlando, Doctor of Philosophy, Supervisor: Fenster, Aaron
Investigating tumor perfusion, glycolysis and pH environments with multimodal in vivo imaging, Qi Qi, Doctor of Philosophy, Supervisor: Thiessen, Jonathan D.
Noninvasive Quantification of Tissue Sodium Concentration in the Kidney Disease Spectrum using 23Na Magnetic Resonance Imaging, Fabio R. Salerno, Doctor of Philosophy, Supervisor: McIntyre, Christopher W.
Targeting Prostate Cancer through High Dose Rate Brachytherapy, Christopher Smith, Doctor of Philosophy, Supervisor: Dr. Aaron Ward
Secretion of Salivary Proteins and their Interactions, Karla Tonelli Bicalho Crosara, Doctor of Philosophy, Supervisor: Siqueira, Walter L.
Activatable synthetic biomarker systems for gene- and cell-based cancer detection and theranostics, TianDuo Wang, Doctor of Philosophy, Supervisor: Ronald, John A.
Characterizing The Transcriptome of Sirt6-Deficient Aortic Smooth Muscle Cells, Ryan J. Wong, Master of Science, Supervisor: Dr. J. Geoffrey Pickering
Development of a Near-Full-View Angle Coverage Photoacoustic Tomography System and Its Application Towards Optical Fluence Distribution Imaging, Lawrence CM Yip, Doctor of Philosophy, Supervisor: Carson, Jeffrey J.L.
Anatomical and Functional Lung Imaging with Volumetric Computed Tomography in Non-Small Cell Lung Cancer, Heather Young, Doctor of Philosophy, Supervisor: Gaede, Stewart
Theses/Dissertations from 2021
Computer-assisted lesion classification and intervention planning for prostate cancer, Ryan M. Alfano, Doctor of Philosophy, Supervisor: Ward, Aaron D.
Frequency dependent diffusion kurtosis measurement in the human brain with oscillating gradients, Kevin B. Borsos, Master of Science, Supervisor: Baron, Corey A.
Investigating a Novel Receptor that Mediates Vasoconstriction in Mouse Femoral Arteries, Joselia Carlos, Master of Science, Supervisor: McGuire, John
Ischemic Stroke Thrombus Characterization through Quantitative Magnetic Resonance Imaging, Spencer D. Christiansen, Doctor of Philosophy, Supervisor: Drangova, Maria
Rapid Recovery Of Cerebral Blood Content And Oxygenation In Adults From Time-Resolved Near-Infrared Spectroscopy, David J. F. Cohen, Master of Science, Supervisor: Diop, Mamadou
In Vivo Detection of CAR-T cell Immunotherapy using 3 Tesla Fluorine-19 MRI, Veronica Dubois, Master of Science, Supervisor: Ronald, John A.
A quantitative assessment of hemodynamic and histological parameters in the mdx mouse model, Sarah Hakim, Master of Science, Supervisor: Hoffman, Lisa M.
Investigating Bone Cement Susceptibility Related Artifacts and Adhesion, Eric Kuindersma, Master of Science, Supervisor: Ravi Menon
Delineating the Skeletal Muscle-Microvessel Regeneration Program after Ischemic Injury, Jason J. Lee, Doctor of Philosophy, Supervisor: Pickering, J. Geoffrey
Using Hyperspectral Near-Infrared Spectroscopy and Diffuse Correlation Spectroscopy to Monitor the Effects of Phenylephrine in the Microcirculation, Laura Mawdsley, Master of Science, Supervisor: Ellis, Christopher G.
Experimental, theoretical, and translational studies of RBC distribution in capillary networks, Asher Mendelson, Doctor of Philosophy, Supervisor: Ellis, Christopher G
Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis, David C.R. Michels, Master of Science, Supervisor: Singh, Krishna K.
Non-invasive quantification of cerebral oxygen metabolism by hybrid positron emission tomography/magnetic resonance imaging, Lucas Diovani Lopes Narciso, Doctor of Philosophy, Supervisor: St Lawrence, Keith
Three-dimensional Ultrasound Imaging For Quantifying Knee Cartilage Volume, Samuel Papernick, Master of Science, Supervisor: Fenster, Aaron
NNeMo (Neonatal NeuroMonitor) - a hybrid optical system to characterize perfusion and metabolism in the newborn brain, Ajay Rajaram, Doctor of Philosophy, Supervisor: Keith St. Lawrence
MRI of structural & functional changes associated with Western diet consumption, Lauren M. Smith, Doctor of Philosophy, Supervisor: McKenzie, Charles A.
Validation of Arterial Spin Labeling for Longitudinal Monitoring and Differential Diagnosis of Frontotemporal Dementia, Tracy Ssali, Doctor of Philosophy, Supervisor: Keith St Lawrence
Phase imaging for reducing macrovascular signal contributions in high-resolution fMRI, Olivia W. Stanley, Doctor of Philosophy, Supervisor: Menon, Ravi S
Endothelial Dysfunction in Hindlimb Arteries of Old Sprague Dawley rats, and the Type 2 Diabetic Zucker Diabetic Sprague Dawley strain., Andrea N. Wang, Master of Science, Supervisor: McGuire, John J.
Developing sodium MRI for longitudinal assessment of chemotherapy of glioma in a rat model of cancer, Xin Yue Wang, Master of Science, Supervisor: Scholl, Timothy J.
Measuring inflammation in the entire myocardium in a canine model of myocardial infarction with hybrid PET/MRI, Benjamin Wilk, Doctor of Philosophy, Supervisor: Prato, Frank S.
Exploring Multimodal Cancer Cell Tracking Using Magnetic Particle Imaging and Akaluc BLI, Ryan J. Williams, Master of Science, Supervisor: Ronald, John A
Laparoscopic Image Recovery and Stereo Matching, Wenyao Xia, Doctor of Philosophy, Supervisor: Terry Peters M.
Theses/Dissertations from 2020
Detecting Command-Driven Brain Activity in Patients with Disorders of Consciousness Using TR-fNIRS, Androu Abdalmalak, Doctor of Philosophy, Supervisor: St. Lawrence, Keith
TSPO PET Detects Acute Neuroinflammation but not Diffuse Chronically Activated MHCII Microglia in the Rat, Nassir Al-Khishman, Master of Science, Supervisor: Thiessen, Jonathan D.
Multimodality imaging to quantify the pulmonary vascular tree in COPD, Andrea L. Barker Odhiambo, Master of Science, Supervisor: Parraga, Grace
Impact of Graded Passive Cycling on Hemodynamics, Cerebral Blood Flow, and Heart Function in Healthy Adults and Septic ICU Patients, Jennifer Chen, Master of Science, Supervisor: McIntyre, Christopher W
Lanthanide Nanoparticles as Contrast Agents for In Vivo Dual Energy Microcomputed Tomography of the Mouse Vasculature, Charmainne Cruje, Doctor of Philosophy, Supervisor: Drangova, Maria
Structure and Function of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy, Doctor of Philosophy, Supervisor: Parraga, Grace
Quantifying Mid-pregnancy Placental Metabolism in Guinea Pigs Fed a Lifelong Western Diet, Mary-Ellen E.T Empey, Master of Science, Supervisor: McKenzie, Charles A.
Improving Hydrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient, Adam Helmy Farag, Doctor of Philosophy, Supervisor: Jean Théberge
A Novel System and Image Processing for Improving 3D Ultrasound-guided Interventional Cancer Procedures, Derek J. Gillies, Doctor of Philosophy, Supervisor: Fenster, Aaron
Metabolic Syndrome Impairs Cerebrovascular Tone and Behaviour in Obese Zucker Rats, Brayden D. Halvorson, Master of Science, Supervisor: Frisbee, Jefferson C.
Chronic Neurological Impairment in Patients with Thrombotic Thrombocytopenic Purpura: Findings in Quantitative MRI, Jeffrey Hamilton, Master of Science, Supervisor: Huang, Susan S.H.
Machine Learning for Prostate Histopathology Assessment, Wenchao Han, Doctor of Philosophy, Supervisor: Ward, Aaron D.
Force Application During Colonoscopy as a Marker of Competence: Development of a Novel Training Device, Jeffrey D. Hawel, Master of Science, Supervisor: Patel, Rajni
Cancer Detection in Radical Prostatectomy Histology using Convolutional Neural Networks, Laurie Huang, Master of Science, Supervisor: Ward, Aaron D.
Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection, Tina Khazaee, Master of Science, Supervisor: David W. Holdsworth
Kinetic Analysis of Dynamic PET for Molecular, Functional and Physiological Characterization of Diseases, Fiona Li, Doctor of Philosophy, Supervisor: Lee, Ting-Yim
Exploring the Effects of Hemodialysis on Renal and Hepatic Blood Flow and Function using CT Perfusion Imaging, Raanan Marants, Doctor of Philosophy, Supervisor: Lee, Ting-Yim
Neurite Orientation Dispersion and Density Imaging in a Rodent Model of Mild Traumatic Brain Injury, Patrick McCunn, Doctor of Philosophy, Supervisor: Bartha, Robert
Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres, Kierstin P. Melo, Master of Science, Supervisor: Foster, Paula
A Genetically-Encoded Reporter for In Vivo Imaging in Deep Tissues, Nivin N. Nasri, Doctor of Philosophy, Supervisor: Scholl, Timothy J.
A Clinically Representative Rat Model of Hip Hemiarthroplasty, Adam DM Paish, Doctor of Philosophy, Supervisor: Holdsworth, David W
A Hybrid PET/MRI Brain Connectivity Approach for Improving Epilepsy Surgical Evaluation, Stefan E. Poirier, Master of Science, Supervisor: Anazodo, Udunna C.
A 3D Microvessel Model for the Study of Endothelial Cell Transluminal Pillar Formation, Emma Kate Prescott, Master of Science, Supervisor: Pickering, J. Geoffrey
Tissue Sodium in CKD Patients, Elena Qirjazi, Master of Science, Supervisor: Christopher McIntyre
Hybrid Optical System for Studying the Dynamic Regulation of Blood Flow/Metabolism in the Adult Brain, Marwan Shahid, Master of Science, Supervisor: StLawrence, Keith
Neurocognitive impairment across the continuum of critical illness: exploration of acute insults, functional risk factors, and clinical monitoring tools., Marat Slessarev, Doctor of Philosophy, Supervisor: Ellis, Christopher
An approach for the in-vivo characterization of brain and heart inflammation in Duchenne Muscular Dystrophy, Joanne Tang, Master of Science, Supervisor: Anazodo, Udunna C.
Quantitative Dynamic PET & CT Perfusion for Cancer Imaging: Diagnosis & Monitoring Treatment Response, Dae-Myoung (Danny) Yang, Doctor of Philosophy, Supervisor: Lee, Ting-Yim
Theses/Dissertations from 2019
Analyzing myocardial R2* mapping pre- and post-myocardial infarction in a canine model, Khalid Abdalla, Master of Science, Supervisor: Dr. Donna Goldhawk
Schrödinger Filtering: A Novel Technique for Removing Gradient Artifact from Electroencephalography Data Acquired during Functional Magnetic Resonance Imaging, Gabriel Bruno Benigno, Master of Science, Supervisor: Menon, Ravi S.
Microvascular Stenosis in Critical Limb Ischemia: Role of Partial Endothelial to Mesenchymal Transition, Jacqueline M. Chevalier, Master of Science, Supervisor: Pickering, J. G.
Monocyte MRI Relaxation Rates are Regulated by Extracellular Iron and Hepcidin, Praveen S.B Dassanayake, Master of Science, Supervisor: Goldhawk, Donna
Development of a Computational Method for Assessing Static Field Induced Torque on Medical Implants, Xiao Fan Ding, Master of Science, Supervisor: Chronik, Blaine A.
Piezo1: Proteins for mechanotransduction and integration of endothelial shear stress & intravascular pressure, Juan Garcia Robledo M.D., Master of Science, Supervisor: Dr. Dwayne Jackson