Medical Biophysics Theses and Dissertations
This collection contains theses and dissertations from the Department of Medical Biophysics, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2018
7T Magnetic Resonance Spectroscopy of Non-Lesional Temporal Lobe Epilepsy, John Robert Adams, Master of Science, Supervisor: Bartha, Robert
Quantitative Analysis of Three-Dimensional Cone-Beam Computed Tomography Using Image Quality Phantoms, Rudy Baronette, Master of Science, Supervisor: Holdsworth, David W.
Characterization of Human Prostate Cancer Using Sodium Magnetic Resonance Imaging, Nolan Christopher Broeke, Master of Science, Supervisor: Scholl, Timothy J
Imaging Biomarkers of Pulmonary Structure and Function, Dante Capaldi, Doctor of Philosophy, Supervisor: Dr. Grace Parraga
High Performance Optical Computed Tomography for Accurate Three-Dimensional Radiation Dosimetry, Kurtis Hendrik Dekker, Doctor of Philosophy, Supervisor: Jordan, Kevin J.
An Integrated Approach to Analyzing Arteriolar Network Hemodynamics., Zahra Farid, Master of Science, Supervisor: Jackson, Dwayne N.
Functional CT Imaging for Myocardial Salvage in Acute Myocardial Infarction Management, Lisa Yun Jeong Hur, Master of Science, Supervisor: Drangova, Maria
Validation of a Hyperspectral NIRS Method for Measuring Tissue Oxygen Saturation, Matthew Kewin, Master of Science, Supervisor: St Lawrence, Keith
Development and validation of a stand-alone DCS system for monitoring absolute cerebral blood flow., Mahro Khalid, Master of Science, Supervisor: St. Lawrence, Keith
Multi-Scale Peripheral Vasculopathy with Metabolic Syndrome, Kent Lemaster, Doctor of Philosophy, Supervisor: Jefferson C. Frisbee
Diffusion and Functional MRI of the Brain Following Sports-Related Impacts and Concussion, Kathryn Y. Manning, Doctor of Philosophy, Supervisor: Menon, Ravi S.
Toward optimization of target planning for magnetic resonance image-targeted, 3D transrectal ultrasound-guided fusion prostate biopsy, Peter Martin, Doctor of Philosophy, Supervisor: Ward, Aaron D.
Investigating the Cortical, Metabolic and Behavioral Effects of Transcranial Direct Current Stimulation in Preparation for Combined Rehabilitation, Kayla N. Ryan, Doctor of Philosophy, Supervisor: Bartha, Robert
Methods for the Investigation of Microvascular Control of Oxygen Distribution, Richard Sove, Doctor of Philosophy, Supervisor: Ellis, Christopher G.
Analysis of Subchondral Bone and Microvessels Using a Novel Vascular Perfusion Contrast Agent and Optimized Dual-Energy Computed Tomography, Justin J. Tse, Doctor of Philosophy, Supervisor: Holdsworth, David W
Optimization of Decision Making in Personalized Radiation Therapy using Deformable Image Registration, Jason Vickress, Doctor of Philosophy, Supervisor: Yartsev, Slav
Theses/Dissertations from 2017
Characterization of an 18F-Growth Hormone Secretagogue Probe for Positron Emission Tomography Imaging of the Growth Hormone Secretagogue Receptor, Ahmed Abbas, Master of Science, Supervisor: Savita Dhanvantari
Using Computed Tomography Perfusion to Evaluate the Blood-Brain-Barrier and Blood-Tumor-Barrier Response following Focused Ultrasound Sonication with Microbubble Administration, Hassaan Ahmed, Doctor of Philosophy, Supervisor: Dr. Ting Lee
Hepcidin-mediated Iron Regulation in P19 Cells is Detectable by MRI, Kobra Alizadeh Pourbouyeh, Master of Science, Supervisor: Goldhawk, Donna E.
Angiogenesis And Neo-Microcirculatory Function In Diseased Tissue Revealed By Intravital Microscopy, Giovanni-Michele Arpino, Doctor of Philosophy, Supervisor: Dr. J Geoffrey Pickering
Novel Determinants of Smooth Muscle Cell-Based Vascular Integrity, Brittany N. Balint, Doctor of Philosophy, Supervisor: Dr. J. Geoffrey Pickering
Therapeutic Application of Carbon Monoxide in Acute Limb Compartment Syndrome, Aurelia Bihari, Doctor of Philosophy, Supervisor: Dr Gediminas Cepinskas
Design of Radio-Frequency Arrays for Ultra-High Field MRI, Ian R O Connell, Doctor of Philosophy, Supervisor: Professor Ravi Menon, Ph.D.
Determining The Detective Quantum Efficiency (DQE) Of X-Ray Detectors In Clinical Environments, Terenz R. Escartin, Master of Science, Supervisor: Dr. Ian Cunningham
Nicotinamide Riboside and the Aortic Response to Angiotensin II Infusion in Mice, Sina A. Ghoreishi, Master of Science, Supervisor: Dr. J. Geoffrey Pickering
Tools for improving high-dose-rate prostate cancer brachytherapy using three-dimensional ultrasound and magnetic resonance imaging, William T. Hrinivich, Doctor of Philosophy, Supervisor: Eugene Wong
A biomechanical approach for real-time tracking of lung tumors during External Beam Radiation Therapy (EBRT), Elham Karami, Doctor of Philosophy, Supervisor: Abbas Samani
3D Ultrasound in the Management of Post Hemorrhagic Ventricle Dilatation, Jessica Kishimoto, Doctor of Philosophy, Supervisor: Sandrine de Ribaupierre
Intraoperative Photoacoustic Imaging of Breast Cancer, Ivan Kosik, Doctor of Philosophy, Supervisor: Jeffrey Carson
Real-time membrane puncture detection using force sensors for micro-injections in phantoms, Szymon Kowal, Master of Science, Supervisor: James Lacefield
In Vivo Magnetic Resonance Imaging Morphometry Measurements of Pulmonary Airspace Enlargement, Eric J. Lessard, Master of Science, Supervisor: Grace Parraga
Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging, Trung Le, Master of Science, Supervisor: Scholl, Timothy J.
A Longitudinal Study of Tumour Metabolism Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging in a Preclinical Model of Glioma, Heeseung Lim, Doctor of Philosophy, Supervisor: Timothy J. Scholl
First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates, Matthew R. Lowerison, Doctor of Philosophy, Supervisor: Dr. James C. Lacefield
Quantification of Cerebral Blood Flow and Oxidative Metabolism in Infants with Post-Hemorrhagic Ventricular Dilatation, Peter McLachlan, Master of Science, Supervisor: Dr. Keith St Lawrence
Developments in PET-MRI for Radiotherapy Planning Applications, John Christian Patrick, Doctor of Philosophy, Supervisor: Dr. Stewart Gaede
The Design, Fabrication, and Characterization of Nanoparticle-Protein Interactions for Theranostic Applications, Wai Hei Tse, Doctor of Philosophy, Supervisor: Dr. Jin Zhang
Automated Vascular Smooth Muscle Segmentation, Reconstruction, Classification and Simulation on Whole-Slide Histology, Yiwen Xu, Doctor of Philosophy, Supervisor: Aaron D. Ward
Evaluating Small Airways Disease in Asthma and COPD using the Forced Oscillation Technique and Magnetic Resonance Imaging, Heather M. Young, Master of Science, Supervisor: Parraga, Grace E.
Theses/Dissertations from 2016
Comprehensive Topological, Geometric, And Hemodynamic Analysis Of The Rat Gluteus Maximus Arteriolar Networks, Mohammed K. Al Tarhuni, Master of Science, Supervisor: Dwayne N. Jackson
Assessment of Post-Treatment Imaging Changes Following Radiotherapy using Magnetic Susceptibility Techniques, Jean-Guy Belliveau, Doctor of Philosophy, Supervisor: Ravi Menon
Quantitative PET-CT Perfusion Imaging of Prostate Cancer, Adam R. Blais, Doctor of Philosophy, Supervisor: Ting-Yim Lee
Energy Subtraction Methods as an Alternative to Conventional X-Ray Angiography, Christiane S. Burton, Doctor of Philosophy, Supervisor: Ian A. Cunningham
Non-Invasive Imaging for the Assessment of Cardiac Dose and Function Following Focused External Beam Irradiation, Omar El-Sherif, Doctor of Philosophy, Supervisor: Dr. Stewart Gaede
Arthrokinematics of the Distal Radioulnar Joint in the Normal Wrist and Following Distal Radius Malunion, Braden M. Gammon, Master of Science, Supervisor: Dr. Graham King
Development and Optimization of 19F-MRI for Tracking Cellular Therapeutics, Jeffrey M. Gaudet, Doctor of Philosophy, Supervisor: Paula J. Foster
Low Frequency Bio-Electrical Impedance Mammography and Dielectric Measurement, Seyyed Hesabgar, Doctor of Philosophy, Supervisor: Dr. Samani
Measuring Brain Serine With Proton Magnetic Resonance Spectroscopy At 3.0 Tesla, Homa Javadzadeh, Master of Science, Supervisor: Dr. Jean Théberge
Characterizing the Role of the Neuropeptide Y-Y5R System in Breast Cancer, Jenna Kara, Master of Science, Supervisor: Dr. Paula Foster
Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease, Samaneh Kazemifar, Doctor of Philosophy, Supervisor: Dr. Robert Bartha
Optimizing the Rehabilitation of Elbow Lateral Collateral Ligament Injuries, Ranita Harpreet Kaur Manocha, Master of Science, Supervisor: Dr. Graham J. W. King
Radiomics for Response Assessment after Stereotactic Radiotherapy for Lung Cancer, Sarah A. Mattonen, Doctor of Philosophy, Supervisor: Dr. Aaron Ward
Magnetic Resonance Imaging of Breast Cancer Brain Metastasis Progression and Responses to Radiotherapy, Donna H. Murrell, Doctor of Philosophy, Supervisor: Dr. Paula Foster
Static Magnetic Field Interactions of Medical Devices in The MRI Environment, Spencer Baird Parent, Master of Science, Supervisor: Dr. Blaine A. Chronik
Hyperpolarized 3He Magnetic Resonance Imaging Phenotypes of Chronic Obstructive Pulmonary Disease, Damien Pike, Doctor of Philosophy, Supervisor: Dr. Grace Parraga
Multi-Nuclear Magnetic Resonance Imaging of Obstructive Lung Disease, Khadija Sheikh, Doctor of Philosophy, Supervisor: Dr. Grace Parraga
Digging Deeper with Diffuse Correlation Spectroscopy, Kyle J. Verdecchia, Doctor of Philosophy, Supervisor: Dr. Keith St. Lawrence
Characterization of N-butyl Cyanoacrylate (NBCA) Glue Polymerization for the Embolization of Brain Arteriovenous Malformations (AVMs), Bill H. Wang, Master of Science, Supervisor: Dr. Stephen P. Lownie
Optimizing Respiratory Gated Intensity Modulated Radiation Therapy Planning and Delivery of Early-Stage Non-Small Cell Lung Cancer, Ilma Xhaferllari, Doctor of Philosophy, Supervisor: Stewart Gaede
Theses/Dissertations from 2015
Gait Analysis and Therapeutic Application of Carbon Monoxide in a Rodent Model of Complex Regional Pain Syndrome Type-1, Hussein Abdo, Master of Science, Supervisor: Dr. David Sanders
Novel Techniques For Investigating The Regulation Of Skeletal Muscle Hemodynamics, Baraa K. Al-Khazraji, Doctor of Philosophy, Supervisor: Dr. Dwayne Jackson
Mapping the Impact and Plasticity of Cortical-Cardiovascular Interactions in Vascular Disease Using Structural and Functional MRI, Udunna C. Anazodo, Doctor of Philosophy, Supervisor: Keith S St Lawrence
Evaluation of novel salivary peptides and a new application method for prevention and treatment of oral disease, Tayebeh Basiri, Master of Science, Supervisor: Walter L. Siqueira
Distal Humerus Hemiarthroplasty: Joint Kinematics, Stability, Congruency and Implant Design, Sagar J. Desai, Master of Science, Supervisor: Dr. Graham King
Hyperpolarized 129Xe Magnetic Resonance Imaging of Radiation-Induced Lung Injury, Ozkan Doganay, Doctor of Philosophy, Supervisor: Giles Santyr
Apodized-Aperture Pixel Design X-Ray Detector for Improvement of Detective Quantum Efficiency at High Spatial Frequencies, Elina Ismailova, Master of Science, Supervisor: Dr Ian Cunningham
Development of a small animal conformal irradiator with dual energy x-ray computed tomography imaging for kilovoltage dosimetry, Michael D. Jensen, Doctor of Philosophy, Supervisor: Eugene Wong
Towards Adaptive Radiotherapy through Development of Treatment Response Prediction, Anthony V. Lausch, Doctor of Philosophy, Supervisor: Dr. Eugene Wong
Three-Dimensional Computed Tomography Measurements of Pulmonary Artery Volumes: Development and Application, Tamas J. Lindenmaier, Master of Science, Supervisor: Dr. Grace Parraga
Characterization of Maga Expression and Iron Uptake in P19 Cells: Implications for Use as a Gene-Based Contrast Agent, Linshan Liu, Master of Science, Supervisor: Donna Goldhawk
Intracellular Acidification in Brain Tumors Induced by Topiramate : In-Vivo Detection Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Kamini Y. Marathe, Master of Science, Supervisor: Dr. Robert Bartha
Laminar fMRI in Auditory Cortex at 7T, Jacob JL Matthews, Master of Science, Supervisor: Dr. Rhodri Cusack
Blood Supply to the Brain via the Carotid Arteries: Examining Obstructive and Sclerotic Disorders using Theoretical and Experimental Models, Onaizah Onaizah, Master of Science, Supervisor: Dr. Mair Zamir
Non-invasive Quantification of Alveolar Morphometry Measurements in Older Never-smokers, Gregory A. Paulin, Master of Science, Supervisor: Dr. Grace Parraga
Investigation of Endogenous In-Vivo Sodium Concentration in Human Prostate Cancer Measured With 23Na Magnetic Resonance Imaging, Justin C. Peterson, Master of Science, Supervisor: Timothy Scholl
Towards the Development of a MagA Reporter Gene Expression Construct for Magnetic Resonance Imaging, Karina Quiaoit, Master of Science, Supervisor: Donna Goldhawk
Estimating Hemodynamics in Skeletal Muscle Arteriolar Networks Reconstructed From In Vivo Data, Amani H. Saleem, Master of Science, Supervisor: Dr. Daniel Goldman
The Kinetics of Cystatin C: A Marker for Dialysis Adequacy, Huang S. Shih-Han, Doctor of Philosophy, Supervisor: Dr. Robert Lindsay
The Development and Validation of a Molecular Imaging Probe Targeted to Cathepsin D for the In-vivo Detection of Alzheimer Disease, Jonatan Snir, Doctor of Philosophy, Supervisor: Drs. Robert Bartha
Feasibility of using Arterial Spin Labeling for Detecting Longitudinal Changes in Cerebral Blood Flow, Tracy Ssali, Master of Science, Supervisor: Dr Keith St Lawrence
Pulmonary Imaging to Better Understand Asthma, Sarah Svenningsen, Doctor of Philosophy, Supervisor: Grace Parraga
Resting and Functional Magnetic Resonance Spectroscopy of Glutamate in Schizophrenia at 7 Tesla, Reggie E. Taylor, Doctor of Philosophy, Supervisor: Dr. Jean Théberge
Role of Cerebrovascular Abnormality in Neurodegenerative Disease and Subcortical Ischemic Disease: CT Perfusion and PET Imaging, Jun Yang, Doctor of Philosophy, Supervisor: Ting-Yim Lee
Novel protective salivary peptides and the chitosan nanoparticles delivery system, Flavia Zaidan Cardoso Salina, Master of Science, Supervisor: Dr. Walter Luiz Siqueira
Evaluation of Radiation Dose-Response in a Breast Cancer Brain Metastasis Model, Niloufar Zarghami, Master of Science, Supervisor: Dr. Eugene Wong
Theses/Dissertations from 2014
The Repair, Reconstruction and Replacement of the Coronoid Process, Bashar Alolabi, Master of Science, Supervisor: Dr. Graham King
Towards Stem Cell Treatment for Duchenne Muscular Dystrophy-Related Cardiomyopathy, Bogdan A. Bondoc, Master of Science, Supervisor: Lisa Hoffman
Advances in image acquisition and filtering for MRI neuroimaging at 7 tesla, Andrew T. Curtis, Doctor of Philosophy, Supervisor: Dr. Ravi Menon
Reinforcement of Flowable Dental Composites with Titanium Dioxide Nanotubes, Manal Dafar, Master of Science, Supervisor: Dr. Amin Rizkalla
Nasopharyngeal method for selective brain cooling and development of a time-resolved near-infrared technique to monitor brain temperature and oxidation status during hypothermia, Mohammad Fazel Bakhsheshi, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee
Metabolic Correlates in Spinal Cord Compression Measured by Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices, Sandy Goncalves, Master of Science, Supervisor: Dr. Neil Duggal
Novel Mechanisms In The Sorting Of Proglucagon To The Secretory Granules Of The Regulated Secretory Pathway, Leonard M. Guizzetti, Doctor of Philosophy, Supervisor: Dr. Savita Dhanvantari
Intensity Based Non-rigid Registration of 3D Whole Mouse Optical and MR Image Volumes, Jacqueline Kathleen Harris, Master of Science, Supervisor: Dr. Charles McKenzie
The Development of a Digital X-ray Imaging System for The Characterization of Transmission of Whole-Body Vibration in Mice, Zhengyi Hu, Master of Science, Supervisor: David W. Holdsworth
Investigating Cortical Changes in Cervical Spondylotic Myelopathy Using Functional Magnetic Resonance Imaging, Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging, Izabela Kowalczyk, Doctor of Philosophy, Supervisor: Dr. Robert Bartha
The Development and Application of a Forearm Simulator to Investigate Radial Head Biomechanics, Brent A. Lanting, Master of Science, Supervisor: Graham King
Pathophysiology of Compartment Syndrome, Abdel-Rahman Lawendy, Doctor of Philosophy, Supervisor: Gediminas Cepinskas
Quantitative Analysis of Relaxation Rate Dependence on Interecho Time in MagA-expressing, Iron-labeled Cells, Casey Yesol Lee, Master of Science, Supervisor: Dr. Neil Gelman
Ultra High Field (7T) Magnetic Resonance Imaging of Intracranial Vessel Wall, Pablo Lopez-Ojeda, Master of Science, Supervisor: Dr. Mel Boulton
Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity, Kathryn Y. Manning, Master of Science, Supervisor: Dr. Ravi Menon