Medical Biophysics Theses and Dissertations
This collection contains theses and dissertations from the Department of Medical Biophysics, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2015
Intracellular Acidification in Brain Tumors Induced by Topiramate : In-Vivo Detection Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Kamini Y. Marathe, Master of Science, Supervisor: Dr. Robert Bartha
Laminar fMRI in Auditory Cortex at 7T, Jacob JL Matthews, Master of Science, Supervisor: Dr. Rhodri Cusack
Blood Supply to the Brain via the Carotid Arteries: Examining Obstructive and Sclerotic Disorders using Theoretical and Experimental Models, Onaizah Onaizah, Master of Science, Supervisor: Dr. Mair Zamir
Non-invasive Quantification of Alveolar Morphometry Measurements in Older Never-smokers, Gregory A. Paulin, Master of Science, Supervisor: Dr. Grace Parraga
Investigation of Endogenous In-Vivo Sodium Concentration in Human Prostate Cancer Measured With 23Na Magnetic Resonance Imaging, Justin C. Peterson, Master of Science, Supervisor: Timothy Scholl
Towards the Development of a MagA Reporter Gene Expression Construct for Magnetic Resonance Imaging, Karina Quiaoit, Master of Science, Supervisor: Donna Goldhawk
Estimating Hemodynamics in Skeletal Muscle Arteriolar Networks Reconstructed From In Vivo Data, Amani H. Saleem, Master of Science, Supervisor: Dr. Daniel Goldman
The Kinetics of Cystatin C: A Marker for Dialysis Adequacy, Huang S. Shih-Han, Doctor of Philosophy, Supervisor: Dr. Robert Lindsay
The Development and Validation of a Molecular Imaging Probe Targeted to Cathepsin D for the In-vivo Detection of Alzheimer Disease, Jonatan Snir, Doctor of Philosophy, Supervisor: Drs. Robert Bartha
Feasibility of using Arterial Spin Labeling for Detecting Longitudinal Changes in Cerebral Blood Flow, Tracy Ssali, Master of Science, Supervisor: Dr Keith St Lawrence
Pulmonary Imaging to Better Understand Asthma, Sarah Svenningsen, Doctor of Philosophy, Supervisor: Grace Parraga
Resting and Functional Magnetic Resonance Spectroscopy of Glutamate in Schizophrenia at 7 Tesla, Reggie E. Taylor, Doctor of Philosophy, Supervisor: Dr. Jean Théberge
Role of Cerebrovascular Abnormality in Neurodegenerative Disease and Subcortical Ischemic Disease: CT Perfusion and PET Imaging, Jun Yang, Doctor of Philosophy, Supervisor: Ting-Yim Lee
Novel protective salivary peptides and the chitosan nanoparticles delivery system, Flavia Zaidan Cardoso Salina, Master of Science, Supervisor: Dr. Walter Luiz Siqueira
Evaluation of Radiation Dose-Response in a Breast Cancer Brain Metastasis Model, Niloufar Zarghami, Master of Science, Supervisor: Dr. Eugene Wong
Theses/Dissertations from 2014
The Repair, Reconstruction and Replacement of the Coronoid Process, Bashar Alolabi, Master of Science, Supervisor: Dr. Graham King
Towards Stem Cell Treatment for Duchenne Muscular Dystrophy-Related Cardiomyopathy, Bogdan A. Bondoc, Master of Science, Supervisor: Lisa Hoffman
Advances in image acquisition and filtering for MRI neuroimaging at 7 tesla, Andrew T. Curtis, Doctor of Philosophy, Supervisor: Dr. Ravi Menon
Reinforcement of Flowable Dental Composites with Titanium Dioxide Nanotubes, Manal Dafar, Master of Science, Supervisor: Dr. Amin Rizkalla
Nasopharyngeal method for selective brain cooling and development of a time-resolved near-infrared technique to monitor brain temperature and oxidation status during hypothermia, Mohammad Fazel Bakhsheshi, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee
Metabolic Correlates in Spinal Cord Compression Measured by Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices, Sandy Goncalves, Master of Science, Supervisor: Dr. Neil Duggal
Novel Mechanisms In The Sorting Of Proglucagon To The Secretory Granules Of The Regulated Secretory Pathway, Leonard M. Guizzetti, Doctor of Philosophy, Supervisor: Dr. Savita Dhanvantari
Intensity Based Non-rigid Registration of 3D Whole Mouse Optical and MR Image Volumes, Jacqueline Kathleen Harris, Master of Science, Supervisor: Dr. Charles McKenzie
The Development of a Digital X-ray Imaging System for The Characterization of Transmission of Whole-Body Vibration in Mice, Zhengyi Hu, Master of Science, Supervisor: David W. Holdsworth
Investigating Cortical Changes in Cervical Spondylotic Myelopathy Using Functional Magnetic Resonance Imaging, Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging, Izabela Kowalczyk, Doctor of Philosophy, Supervisor: Dr. Robert Bartha
The Development and Application of a Forearm Simulator to Investigate Radial Head Biomechanics, Brent A. Lanting, Master of Science, Supervisor: Graham King
Pathophysiology of Compartment Syndrome, Abdel-Rahman Lawendy, Doctor of Philosophy, Supervisor: Gediminas Cepinskas
Quantitative Analysis of Relaxation Rate Dependence on Interecho Time in MagA-expressing, Iron-labeled Cells, Casey Yesol Lee, Master of Science, Supervisor: Dr. Neil Gelman
Ultra High Field (7T) Magnetic Resonance Imaging of Intracranial Vessel Wall, Pablo Lopez-Ojeda, Master of Science, Supervisor: Dr. Mel Boulton
Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity, Kathryn Y. Manning, Master of Science, Supervisor: Dr. Ravi Menon
Fully Automated Segmentation and Quantification of Abdominal Adipose Tissue Compartments in Mouse MRI, Colin M. McCurdy, Master of Science, Supervisor: Charles McKenzie
Temperature and pH Imaging using Chemical Exchange Saturation Transfer (CEST) MRI Contrast, Nevin Neil Campbell McVicar, Doctor of Philosophy, Supervisor: Dr. Robert Bartha
Pre-diabetes and sympathetic nervous system mediated microvascular dysregulation in skeletal muscle, Nicole M. Novielli, Doctor of Philosophy, Supervisor: Dr. Dwayne Jackson
Dual energy imaging for determining urinary calculi composition: A theoretical and experimental study with computed tomography, Stephanie Nykamp, Master of Science, Supervisor: Dr. Ian Cunningham
A Non-Contrast Magnetic Resonance Imaging Technique to Assess Blood-Brain Barrier Permeability, Harini Pandithasekera, Master of Science, Supervisor: Dr. Keith St. Lawrence
Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease, Jacob Penner, Doctor of Philosophy, Supervisor: Robert Bartha
Investigation of Techniques to increase the Field of View of a Staring Transducer Array for Photoacoustic Imaging, Avery Raess, Master of Science, Supervisor: Dr. Jeffrey Carson
MRI Relaxation Rates: A Quantitative Approach to Track Tumour Cells Expressing MagA, Anindita Sengupta, Master of Science, Supervisor: Dr. Neil Gelman
Multiparametric Imaging and MR Image Texture Analysis in Brain Tumors, Harish A. Sharma, Doctor of Philosophy, Supervisor: Dr. Robert Bartha
Potential for Photoacoustic Imaging of Neonatal Brain, Pantea Tavakolian, Master of Science, Supervisor: Dr. Jeffrey Carson
The Effect of Diffusive and Convective Sodium Balance During Hemodialysis on Interdialytic Weight Gain, Benjamin Thomson, Master of Science, Supervisor: Dr. Robert Lindsay
A Pseudo Non-Cartesian Pulse Sequence For Hyperpolarized Xenon-129 Gas MRI of Rodent Lungs At Low Magnetic Field Strength, Krzysztof Wawrzyn, Master of Science, Supervisor: Giles Edmund Santyr
Three-dimensional Photoacoustic Tomography System Design Analysis and Optimization, Philip Wong, Master of Science, Supervisor: Dr. Jeffrey J.L. Carson
Functional Imaging of Malignant Gliomas with CT Perfusion, Timothy Pok Chi Yeung, Doctor of Philosophy, Supervisor: Drs. Glenn Bauman
Theses/Dissertations from 2013
Delta Relaxation Enhanced Magnetic Resonance - Development and Application of a Field-Cycling Contrast Mechanism, Yonathan Araya, Master of Science, Supervisor: Dr. Timothy Scholl
Effects of a Power-Line Frequency Magnetic Field on Human Cognitive Processing, Michael Corbacio, Master of Science, Supervisor: Dr Alexandre Legros
Complex Shoulder Instability: The Role of the Latarjet Coracoid Transfer, Ryan Degen, Master of Science, Supervisor: Dr. Jim Johnson
Improving Acute Stroke Management with CT Perfusion Imaging: Approaches to Treatment Guidance and Brain Tissue Salvage, Christopher D. d'Esterre, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee
The Impact of Lateral Electron Disequilibrium on Stereotactic Body Radiation Therapy of Lung Cancer, Brandon Disher, Doctor of Philosophy, Supervisor: Dr. Jerry J. Battista
Imaging Breast Cancer Progression and Lymph Node Metastases in Murine Models Using MRI and Magnetic Nanoparticles, Vasiliki Economopoulos, Doctor of Philosophy, Supervisor: Dr. Paula Foster
On The Development of a Dynamic Contrast-Enhanced Near-Infrared Technique to Measure Cerebral Blood Flow in the Neurocritical Care Unit, Jonathan T. Elliott, Doctor of Philosophy, Supervisor: Keith St. Lawrence
Magnetic resonance imaging of brain tissue abnormalities: transverse relaxation time in autism and Tourette syndrome and development of a novel whole-brain myelin mapping technique, Yann Gagnon, Doctor of Philosophy, Supervisor: Drs. Jean Théberge
Development of a translational animal model of sepsis, Nathaniel E. Hayward, Master of Science, Supervisor: Dr. Christopher G Ellis
Pulmonary Structure and Function in Chronic Obstructive Pulmonary Disease Evaluated using Hyperpolarized Noble Gas Magnetic Resonance Imaging, Miranda Kirby, Doctor of Philosophy, Supervisor: Dr. Grace Parraga
Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer, Christiane L. Mallett, Doctor of Philosophy, Supervisor: Paula Foster
Evaluating and Improving 4D-CT Image Segmentation for Lung Cancer Radiotherapy, Spencer P. Martin, Master of Science, Supervisor: Dr Stewart Gaede
The Effect of Selective Hypothermia on Stroke Volume, Thomas K. Mattingly, Master of Science, Supervisor: Stephen Lownie, MD
Two dimensional angular domain optical imaging in biological tissues, Eldon Ng, Master of Science, Supervisor: Jeffrey J.L. Carson
Atlas-Based Attenuation Correction for PET/MRI, John Christian Patrick, Master of Science, Supervisor: Dr. Robert Stodlika
Magnetic Resonance Imaging of Iron in Early Multiple Sclerosis at 3 Tesla, Matthew P. Quinn, Doctor of Philosophy, Supervisor: Ravi Menon
Design and Development of a Novel Expanding Pedicle Screw for Use in the Osteoporotic Lumbar Spine, Parham Rasoulinejad, Master of Science, Supervisor: Dr. Chris Bailey
Investigating Adenosine’s Role in Controlling the Cerebral Metabolic Rate of Oxygen following Hypoxia-Ischemia, Mustafa Ridha, Master of Science, Supervisor: Dr. Keith St. Lawrence
Glass-Ceramics for Non-Metallic Dental Implant Applications, Selma Saadaldin, Doctor of Philosophy, Supervisor: Dr. Amin Rizkalla
Image quality of energy-dependent approaches for x-ray angiography, Jesse Evan Tanguay, Doctor of Philosophy, Supervisor: Ian Cunningham
Metabolic Imaging of Early Radiation-Induced Lung Injury Using Hyperpolarized 13C-Pyruvate in Rodent Lungs, Kundan Thind, Doctor of Philosophy, Supervisor: Giles Santyr
Theses/Dissertations from 2012
The Differential Expression of EGFL7 Transcripts during Angiogenesis in Human Fibrosarcoma, Navid Baktash, Master of Science, Supervisor: Dr. John D. Lewis
Three-dimensional Ultrasound Measurements of Carotid Atherosclerosis in Vulnerable Patient Populations, Daniel N. Buchanan, Master of Science, Supervisor: Dr. Grace Parraga
Peptide-Mediated Targeting of Angiogenesis for Molecular Imaging and Treatment of Cancer, Choi-Fong Cho, Doctor of Philosophy, Supervisor: Dr. John Lewis
Applications of Rapid Cardiac Micro-CT, Sarah A. Detombe, Doctor of Philosophy, Supervisor: Dr. Maria Drangova
Coherent Scatter Computed Tomography for Core Composition Analysis of Intact Kidney Stones - Prospective Clinical Study, Cristian Dihel, Master of Science, Supervisor: Dr. Ian Cunningham
Modeling Oxygen Transport in Three-Dimensional Capillary Networks, Graham M. Fraser, Doctor of Philosophy, Supervisor: Christopher G. Ellis
In vivo magnetic resonance imaging for assessing the integrity of the blood-tumour barrier in a mouse model of melanoma brain metastasis, Mariama Henry, Master of Science, Supervisor: Dr. Paula Foster
MRI-Based Attenuation Correction in Emission Computed Tomography, Harry R. Marshall, Doctor of Philosophy, Supervisor: Robert Z Stodilka
The Impact of the Neuropeptide Y System on the Progression of Breast Cancer, Philip J. Medeiros, Doctor of Philosophy, Supervisor: Dr. Dwayne Jackson
Characterization of Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy (DMD) Using Echocardiography, DCE-CT, and PET-FDG, Seyed Hamed Moazami, Master of Science, Supervisor: Dr. Lisa Hoffman
Targeted Intracellular Therapeutic Delivery Using Liposomes Formulated with Multifunctional FAST proteins, Rae L. Nesbitt, Master of Science, Supervisor: Dr. John Lewis
Assessment of Wear in Total Knee Arthroplasty Using Advanced Radiographic Techniques, Matthew G. Teeter, Doctor of Philosophy, Supervisor: David W Holdsworth
Theses/Dissertations from 2011
Glutamatergic Metabolites and Gray Matter Losses in Schizophrenia: A Longitudinal Study Using In Vivo Proton Magnetic Resonance Spectroscopy, Naoko Aoyama, Doctor of Philosophy, Supervisor: Dr. Peter C. Williamson
In Vivo Cellular MRI In Experimental Traumatic Spinal Cord Injury, Laura E. Gonzalez-Lara, Doctor of Philosophy, Supervisor: Paula J. Foster, Ph.D.
Strategies for Reducing the Impact of Tumour Motion During Helical Tomotherapy, Bryan Kim, Doctor of Philosophy, Supervisor: Dr. Jerry Battista
From Isolated Tumour Cells to Overt Lymph Node Metastases: Biological and Imaging Studies on the Development of Experimental Lymph Node Metastases, Michael M. Lizardo, Doctor of Philosophy, Supervisor: Dr. Ann F. Chambers
Metastatic Disease: Interactions Between Tumor Cells and Host Environment During Cancer Cell Spread, Jennifer M. MacLean, Doctor of Philosophy, Supervisor: Drs Ann F Chambers
Quantification of Pulmonary Ventilation using Hyperpolarized 3He Magnetic Resonance Imaging, Lindsay Mathew, Doctor of Philosophy, Supervisor: Dr. Grace Parraga
Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics, David D. McErlain, Doctor of Philosophy, Supervisor: Dr. David W. Holdsworth
Assessing and Improving 4D-CT Imaging for Radiotherapy Applications, Greg Pierce, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee
Magnetic Field Effects On The Neuroprocessing Of Pain, John A. Robertson, Doctor of Philosophy, Supervisor: Dr. Alex Thomas
Real-time Three-dimensional Photoacoustic Imaging, Michael B. Roumeliotis, Doctor of Philosophy, Supervisor: Dr. Jeffrey Carson
Hemodynamics in the Stenosed Carotid Bifurcation with Plaque Ulceration, Emily Y. Wong, Doctor of Philosophy, Supervisor: Dr. David Holdsworth
Theses/Dissertations from 2010
Improvements in Cardiac Spect/CT for the Purpose of Tracking Transplanted Cells, Eric Sabondjian, Doctor of Philosophy, Supervisor: Robert Z. Stodilka