Anatomy and Cell Biology Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Anatomy and Cell Biology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

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Theses/Dissertations from 2023

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Transferring organelles into native neurons: A disease-modifying therapy for neurodegenerative disorders, Lohiny Balendran

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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease, Kaitlyn M. Flondra

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Identifying Novel Transcriptional Regulators in Trophoblast Development, Mariyan J. Jeyarajah

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Cognitive, neurophysiological, and molecular alterations following noise-induced hearing loss, Salonee Patel

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Offspring Susceptibility of Developing Depressive-like Phenotypes and Metabolic Dysfunction Following Prenatal Alcohol Exposure and Juvenile Stress in a Mouse Model, Amy Pietrantonio

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Investigating the Role of Endothelial BReast CAncer Susceptibility Gene 2 in Doxorubicin-induced Cardiotoxicity, Berk U. Rasheed

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Pannexin3 in exercise, obesity, and osteoarthritis, Brent Wakefield

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Haptic Simulation in Cerebral Angiography: Establishing New Clinical Competency Targets, Oleksiy Zaika

Theses/Dissertations from 2022

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Past and Present Experience Alters Audiovisual Temporal Perception in Rats, Mohammed Al-youzbaki

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The Effect of Maternal Immune Activation on Placental and Fetal Development in Rats, Kelly J. Baines

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The role of Ire1 in azole sensitivity in Saccharomyces cerevisiae, Malisa Nilakni Fernando

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Role of decorin at the fetal-maternal interface, Chidambra D. Halari

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Elucidating the Role of Hypoxia Signaling in Placental Trophoblast Differentiation, Adam Jaremek

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Connexin 43 Contributes to Phenotypic Variability of the Mouse Skull, Elizabeth Jewlal

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Role of the epithelial-to-mesenchymal transition (EMT) on circulating tumor cell (CTC) and metastasis biology in prostate cancer, Jenna M. Kitz

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Extrinsic And Intrinsic Factors Influencing Homeostasis And Repair In Oral Tissues, Georgia Nikoloudaki

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Anticancer Effects and Mechanisms of CFI-400945 and Radiation in Breast Cancer, Sierra M. Pellizzari

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Identifying and developing candidate indicators of brain inflammation, Austyn D. Roseborough

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Localization and function of Pannexin2 isoform 202, Marina D. Sertsis

Theses/Dissertations from 2021

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Expression of pannexin1 in brain metastases derived from lung cancer, Rober Abdo

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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas, Andrew M.A. Deweyert

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Investigation of β5 integrin function in epithelial ovarian cancer cell adhesion and metastatic properties of spheroids, Dolly Dhaliwal

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Erythrokeratodermia Variabilis et Progressiva (EKVP) Linked Cx30.3 Mutants can be Selectively Rescued by Co-expression of Wildtype Keratinocyte Connexins, Rhett O. Figliuzzi

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Characterization of tissue-specific matrix-derived bioscaffolds for nucleus pulposus cell culture, Marco A. Herrera Quijano

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Cholinergic Modulation of Behaviour, Ornela Kljakic

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Understanding the Kinomic Contributions to Tyrosine Kinase Inhibitor Resistance in Triple Negative Breast Cancer, Cory Lefebvre

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Regional lipid expression abnormalities identified using MALDI IMS correspond to MRI-defined white matter hyperintensities within post-mortem human brain tissue., William J. Pinsky

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Matrin3 Misfolding in Amyotrophic Lateral Sclerosis, Ahmed Salem

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The regulation of Pannexin1 and Pannexin2 in the skin in health and disease, Rafael E. Sanchez Pupo

Theses/Dissertations from 2020

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Characterising the Role of OVOL1 in Cell Growth Regulation, Maram Albakri

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Vascular Stiffening and the Brain: Direct Measures of Cerebrovascular Stiffness in Aging and Vasodilation, Christopher S. Balestrini

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Regulation of Endoplasmic Reticulum Stress in Saccharomyces cerevisiae, Sarah R. Chadwick

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3D Culture Strategies for the Dynamic Expansion and Preconditioning of Adipose-derived Stromal Cells on Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han

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Intranasal Administration of Exosome Packaged Catalase-SKL, a Novel Antioxidant Delivery System Across the Blood-Brain Barrier in mice: Biodistribution and Safety, Qingfan Liu

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Assessment of Autistic-like Behaviour of Mice Lacking ATRX in Forebrain Glutamatergic Neurons, Nicole A. Martin-Kenny

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Extracellular Matrix-Derived Modular Bioscaffolds for Soft Connective Tissue Regeneration, Pascal Morissette Martin

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Evaluation of the Basic Science Pre-Clerkship Curriculum in Medicine at Western University, Madeleine E. Norris

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DNAJC7, a Molecular Chaperone Protein that Modulates Protein Misfolding in Amyotrophic Lateral Sclerosis (ALS), Meaghan Kathleen Stoltz

Theses/Dissertations from 2019

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The Role of Connexin and Pannexin Large-Pore Channels in Hearing, Julia Abitbol

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Hyperactive TORC1 Sensitizes Yeast Cells to Endoplasmic Reticulum Stress by Compromising Cell Wall Integrity, Khadija Ahmed

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Elucidating the mechanism of NUAK1 function in Ovarian Cancer Metastasis, Jamie Fritz

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Comorbid Metabolic Syndrome and Prodromal Alzheimer's Disease in a Rat Model, Nadezda Ivanova

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Translational Control of Stress Induced Breast Cancer Plasticity, Michael Jewer

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The Role of Tra1 in Cellular Stress Responses in Yeast: Implications for Human Diseases, Yuwei Jiang

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AMPK Signalling As A Regulator Of Autophagy In A Model Of Ovarian Tumour Dormancy, Jeremi Laski

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Characterization of Wilms' Tumour 1 (Wt1) as a Biomarker for Fibrosis in Duchenne Muscular Dystrophy, Patrick Murphy

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Biochemical and Functional Analyses of PANX1 Variants, Daniel Nouri Nejad

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Anaplastic Thyroid Cancer: Identification of Candidate Therapeutics and Mechanisms of Disease Progression, Nicole Pinto

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Cortical Plasticity following Adult-Onset Hearing Loss, Ashley L. Schormans

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Cell Recruitment and Differentiation in Wound Repair, John Walker

Theses/Dissertations from 2018

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Teaching Neuroanatomy Virtually: Integrating an Interactive 3D E-Learning Resource for Enhanced Neuroanatomy Education, Lauren Allen

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Detecting A-Series Ganglioside Expression Profile Changes During Microglial Activation, Mona M. Alshaikh

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Anatomy of the Infrarenal Aortic Plexus: Implications for Nerve-Sparing Retroperitoneal Lymph Node Dissection, Tyler Beveridge

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Assessing Cognitive Function in Chronic Sport-Related Head Impacts and Aging, Danielle Brewer-Deluce

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Examining the role of ganglioside homeostasis in neurodegeneration and aging using MALDI imaging mass spectrometry, Sarah Caughlin

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Proteomic Characterization of Ovarian and Breast Cancer Microenvironments for Improved Diagnostics and Therapeutic Targeting, Dylan Z. Dieters-Castator

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Perturbing Gangliosides In-vitro Using Ambroxol as a Treatment for Neurodegeneration, Asmahan Elsariti

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Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH), Dale Edward Fournier

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Lung-derived selectins interact with CD44 and enhance the migration of breast cancer cells, Sami U. Khan

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White Matter Inflammation And Executive Dysfunction: Implications For Alzheimer Disease And Vascular Cognitive Impairment, Alexander Levit

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Influence of the Metastatic Microenvironment on Stem-like Human Breast Cancer Cells, Ashkan Sadri

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Localization and trafficking of Pannexin 1 in polarized and non-polarized cells, Michelle Shum

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The Brain-Heart Connection: Establishment of a Novel Rodent Model of Focal Insular Ischemic Stroke to Examine the Pathophysiology of Stroke-Induced Heart Injury, Victoria Thorburn

Theses/Dissertations from 2017

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Building Muscle: The Role of Insulin-Like Growth Factor Binding Protein-6 and Insulin-Like Growth Factors in the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle, Doaa Aboalola

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Investigating the Role of Cortical Inhibition in Tinnitus, Krystal Beh

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Mechanisms underlying executive function deficits, Sagar Jayawantrao Desai

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Investigation of Chitosan-based Hydrogels as a Cell Delivery Platform for Adipose-derived Stem/Stromal Cell Transplantation to Promote Angiogenesis in Ischemic Tissues, Jobanpreet Singh Dhillon

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Inhibition of Pannexin 1 reduces tumorigenic properties of human melanoma, Taylor J. Freeman

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Role of the Cholinergic Pedunculopontine Tegmental Nucleus in Long-term Habituation, Andrea Gaile Louttit

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NUAK1 Has Tumor Suppressive Activity in Epithelial Ovarian Cancer, Parima Saxena

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Altered Cortical Oscillations: Investigations into a Putative Neural Correlate of Tinnitus, Gregory G P Sigel

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The Role of Cytoplasmic Polyadenylation Element Binding Protein -2 (CPEB-2) in Human Breast Cancer, Joshua Tordjman

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Examination and Assessment of Commercial Anatomical E-Learning Tools: Software Usability, Dual-Task Paradigms and Learning, Sonya E. Van Nuland

Theses/Dissertations from 2016

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The Differential Effects of Connexin26 and Connexin43 in Modulating Epidermal Health in Response to UV Injury, Katanya C. Alaga

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The Role of Forebrain Cholinergic Signalling In Regulating Hippocampal Function And Neuropathology, Mohammed Al-Onaizi

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The Role of Cholinergic Neurotransmission in Sensory Filtering and Sensorimotor Gating, Erin Azzopardi

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Establishing an In Vivo Model for Intratumoral Modulation Therapy for Glioblastoma Multiforme, Mitchell D. Cooper

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Sensory Filtering and Cognitive Function in a Valproic Acid Rat Model of Autism, Theshani A. De Silva

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Comprehensive Molecular Characterization of Human NODAL, Scott D. Findlay

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The Behavioural Phenotype of pThr175-Tau Expression in the Hippocampus of Female Adult Sprague Dawley Rats, Jason J. Gopaul

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Angiogenic Therapy in a Fibrotic Murine Model of Duchenne Muscular Dystrophy, Kelly M. Gutpell

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Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice, Meghan L. Jelen

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Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo, Vanessa R. Lee

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Exploring the regulation and function of epithelial-mesenchymal plasticity in ovarian cancer spheroids, Samah Rafehi

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Behavioural Inflexibility And White Matter Inflammation In An Aged hAPP Rat With Subcortical Stroke, Aaron M. Regis

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Oncolytic Virus Therapy for the Treatment of Metastatic Ovarian Cancer, Jessica Tong

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Investigating Stromal Contributions to the Regulation of Cancer Progression, Krista M. Vincent

Theses/Dissertations from 2015

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Design, Implementation, and Evaluation of an Online Systemic Human Anatomy Course with Laboratory, Stefanie M. Attardi

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Co-Morbidity Of Alzheimer’s Disease And Stroke: Cognitive Deficits And Cellular Pathologies In Two Co-Morbid Animal Models, Jennifer L. Au

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High Throughput Screening For Drug Discovery In Head And Neck Squamous Cell Carcinoma, Morgan D. Black

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Hierarchical Organization in Auditory Cortex of the Cat Using High-Field Functional Magnetic Resonance Imaging, Amee J. Hall

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The Role of Cytoplasmic Polyadenylation Element Binding Protein-2 (CPEB-2) in Breast Cancer, Asma Hasan

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Underlying Mechanisms Regulating Gingival Healing and Fibrosis, Shawna Soheun Kim

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Clinical and Experimental Importance of Circulating Tumor Cells in Prostate Cancer, Lori Lowes

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Analyzing A-series gangliosides in neurons following exposure to glutamate, Dae Hee Park

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The lung microenvironment influences the metastatic behaviour of breast cancer cells in an innovative 3D ex vivo pulmonary metastasis model, Matt M. Piaseczny

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The Role of Bone-Derived Osteopontin in the Migration and Stem-Like Behavior of Breast Cancer Cells, Graciella Pio

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Exploring And Training Spatial Reasoning Via Eye Movements: Implications On Performance, Victoria A. Roach

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Investigating the role of hydrogen sulfide in the survival, growth and angiogenic potential of clear cell renal cell carcinoma cell lines and xenografts, Eric Sonke

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Evaluating the pathological and behavioural consequences of injecting amyloid beta oligomers in the rat, Ryan S. Wong