Anatomy and Cell Biology Theses and Dissertations
This collection contains theses and dissertations from the Department of Anatomy and Cell Biology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2024
Studies of Anticancer Mechanisms of CFI-400945, Radiation and its Combination in Triple Negative Breast Cancer, Harjot Athwal
Unfolding the Role of Endoplasmic Reticulum Stress and IRE1 Signaling in Trophoblast Differentiation, Diba Chowdhury
Interrogating the ability of ambroxol to modulate microglia functions, Sairam Gajavelli
Characterizing Hypoxia, Neutrophil Persistence and Revascularization in the Murine db/db Model of Type II Diabetic Impaired Skin Healing, Michael R. Grynyshyn
Investigating Synergistic Combinations of MRT68921 and Afatinib as a Therapeutic Strategy in Epithelial Ovarian Cancer, Tiffany P A Johnston
The Integrated stress response, a novel mediator of pro-inflammatory microglia phenotypes, Erica Kane
Differential effects of cannabis vapour constituents on brain connectivity: Exploring the long-term effects of adolescent exposure, Pedro Marinho
The Roles of FABP3 in Endothelial Dysfunction and the Transcriptomic Insights into Cardiovascular Disease, Chi Hien Nguyen
The Characterization of Pannexin 1 and Pannexin 3 Channels and their Isoforms in Skin Health and Keratinocytic Cancers, Brooke O'Donnell
Understanding How Hypoxia Alters the Breast Cancer Proteome in the Context of Molecular Subtypes and Metastatic Organotropism, David P. Susman
Investigating the Role of Pannexin 1 in Patient-Derived Glioblastoma Multiforme Cells, Carlijn Van Kessel
Functional Profiling of the Gut Microbiome from Bulk to Single-Cell: A Pilot Study on Exercise-Induced Effects, Qianrui (Ray) Wang
Human Trophoblast Differentiation In Vitro Within 3D Matrix-Free Cultures, Michael Zheng
Theses/Dissertations from 2023
Transferring organelles into native neurons: A disease-modifying therapy for neurodegenerative disorders, Lohiny Balendran
Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease, Kaitlyn M. Flondra
Identifying Novel Transcriptional Regulators in Trophoblast Development, Mariyan J. Jeyarajah
Cognitive, neurophysiological, and molecular alterations following noise-induced hearing loss, Salonee Patel
Investigating the Role of Endothelial BReast CAncer Susceptibility Gene 2 in Doxorubicin-induced Cardiotoxicity, Berk U. Rasheed
Pannexin3 in exercise, obesity, and osteoarthritis, Brent Wakefield
Haptic Simulation in Cerebral Angiography: Establishing New Clinical Competency Targets, Oleksiy Zaika
Theses/Dissertations from 2022
Past and Present Experience Alters Audiovisual Temporal Perception in Rats, Mohammed Al-youzbaki
The Effect of Maternal Immune Activation on Placental and Fetal Development in Rats, Kelly J. Baines
The role of Ire1 in azole sensitivity in Saccharomyces cerevisiae, Malisa Nilakni Fernando
Role of decorin at the fetal-maternal interface, Chidambra D. Halari
Elucidating the Role of Hypoxia Signaling in Placental Trophoblast Differentiation, Adam Jaremek
Connexin 43 Contributes to Phenotypic Variability of the Mouse Skull, Elizabeth Jewlal
Role of the epithelial-to-mesenchymal transition (EMT) on circulating tumor cell (CTC) and metastasis biology in prostate cancer, Jenna M. Kitz
Extrinsic And Intrinsic Factors Influencing Homeostasis And Repair In Oral Tissues, Georgia Nikoloudaki
Anticancer Effects and Mechanisms of CFI-400945 and Radiation in Breast Cancer, Sierra M. Pellizzari
Identifying and developing candidate indicators of brain inflammation, Austyn D. Roseborough
Localization and function of Pannexin2 isoform 202, Marina D. Sertsis
Theses/Dissertations from 2021
Expression of pannexin1 in brain metastases derived from lung cancer, Rober Abdo
Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas, Andrew M.A. Deweyert
Investigation of β5 integrin function in epithelial ovarian cancer cell adhesion and metastatic properties of spheroids, Dolly Dhaliwal
Erythrokeratodermia Variabilis et Progressiva (EKVP) Linked Cx30.3 Mutants can be Selectively Rescued by Co-expression of Wildtype Keratinocyte Connexins, Rhett O. Figliuzzi
Characterization of tissue-specific matrix-derived bioscaffolds for nucleus pulposus cell culture, Marco A. Herrera Quijano
Cholinergic Modulation of Behaviour, Ornela Kljakic
Understanding the Kinomic Contributions to Tyrosine Kinase Inhibitor Resistance in Triple Negative Breast Cancer, Cory Lefebvre
Regional lipid expression abnormalities identified using MALDI IMS correspond to MRI-defined white matter hyperintensities within post-mortem human brain tissue., William J. Pinsky
Matrin3 Misfolding in Amyotrophic Lateral Sclerosis, Ahmed Salem
The regulation of Pannexin1 and Pannexin2 in the skin in health and disease, Rafael E. Sanchez Pupo
Theses/Dissertations from 2020
Characterising the Role of OVOL1 in Cell Growth Regulation, Maram Albakri
Vascular Stiffening and the Brain: Direct Measures of Cerebrovascular Stiffness in Aging and Vasodilation, Christopher S. Balestrini
Regulation of Endoplasmic Reticulum Stress in Saccharomyces cerevisiae, Sarah R. Chadwick
Assessment of Autistic-like Behaviour of Mice Lacking ATRX in Forebrain Glutamatergic Neurons, Nicole A. Martin-Kenny
Extracellular Matrix-Derived Modular Bioscaffolds for Soft Connective Tissue Regeneration, Pascal Morissette Martin
Evaluation of the Basic Science Pre-Clerkship Curriculum in Medicine at Western University, Madeleine E. Norris
DNAJC7, a Molecular Chaperone Protein that Modulates Protein Misfolding in Amyotrophic Lateral Sclerosis (ALS), Meaghan Kathleen Stoltz
Theses/Dissertations from 2019
The Role of Connexin and Pannexin Large-Pore Channels in Hearing, Julia Abitbol
Hyperactive TORC1 Sensitizes Yeast Cells to Endoplasmic Reticulum Stress by Compromising Cell Wall Integrity, Khadija Ahmed
Elucidating the mechanism of NUAK1 function in Ovarian Cancer Metastasis, Jamie Fritz
Comorbid Metabolic Syndrome and Prodromal Alzheimer's Disease in a Rat Model, Nadezda Ivanova
Translational Control of Stress Induced Breast Cancer Plasticity, Michael Jewer
The Role of Tra1 in Cellular Stress Responses in Yeast: Implications for Human Diseases, Yuwei Jiang
AMPK Signalling As A Regulator Of Autophagy In A Model Of Ovarian Tumour Dormancy, Jeremi Laski
Characterization of Wilms' Tumour 1 (Wt1) as a Biomarker for Fibrosis in Duchenne Muscular Dystrophy, Patrick Murphy
Biochemical and Functional Analyses of PANX1 Variants, Daniel Nouri Nejad
Anaplastic Thyroid Cancer: Identification of Candidate Therapeutics and Mechanisms of Disease Progression, Nicole Pinto
Cortical Plasticity following Adult-Onset Hearing Loss, Ashley L. Schormans
Cell Recruitment and Differentiation in Wound Repair, John Walker
Theses/Dissertations from 2018
Teaching Neuroanatomy Virtually: Integrating an Interactive 3D E-Learning Resource for Enhanced Neuroanatomy Education, Lauren Allen
Detecting A-Series Ganglioside Expression Profile Changes During Microglial Activation, Mona M. Alshaikh
Anatomy of the Infrarenal Aortic Plexus: Implications for Nerve-Sparing Retroperitoneal Lymph Node Dissection, Tyler Beveridge
Assessing Cognitive Function in Chronic Sport-Related Head Impacts and Aging, Danielle Brewer-Deluce
Examining the role of ganglioside homeostasis in neurodegeneration and aging using MALDI imaging mass spectrometry, Sarah Caughlin
Proteomic Characterization of Ovarian and Breast Cancer Microenvironments for Improved Diagnostics and Therapeutic Targeting, Dylan Z. Dieters-Castator
Perturbing Gangliosides In-vitro Using Ambroxol as a Treatment for Neurodegeneration, Asmahan Elsariti
Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH), Dale Edward Fournier
Lung-derived selectins interact with CD44 and enhance the migration of breast cancer cells, Sami U. Khan
White Matter Inflammation And Executive Dysfunction: Implications For Alzheimer Disease And Vascular Cognitive Impairment, Alexander Levit
Influence of the Metastatic Microenvironment on Stem-like Human Breast Cancer Cells, Ashkan Sadri
Localization and trafficking of Pannexin 1 in polarized and non-polarized cells, Michelle Shum
The Brain-Heart Connection: Establishment of a Novel Rodent Model of Focal Insular Ischemic Stroke to Examine the Pathophysiology of Stroke-Induced Heart Injury, Victoria Thorburn
Theses/Dissertations from 2017
Investigating the Role of Cortical Inhibition in Tinnitus, Krystal Beh
Mechanisms underlying executive function deficits, Sagar Jayawantrao Desai
Investigation of Chitosan-based Hydrogels as a Cell Delivery Platform for Adipose-derived Stem/Stromal Cell Transplantation to Promote Angiogenesis in Ischemic Tissues, Jobanpreet Singh Dhillon
Inhibition of Pannexin 1 reduces tumorigenic properties of human melanoma, Taylor J. Freeman
Role of the Cholinergic Pedunculopontine Tegmental Nucleus in Long-term Habituation, Andrea Gaile Louttit
NUAK1 Has Tumor Suppressive Activity in Epithelial Ovarian Cancer, Parima Saxena
Altered Cortical Oscillations: Investigations into a Putative Neural Correlate of Tinnitus, Gregory G P Sigel
The Role of Cytoplasmic Polyadenylation Element Binding Protein -2 (CPEB-2) in Human Breast Cancer, Joshua Tordjman
Examination and Assessment of Commercial Anatomical E-Learning Tools: Software Usability, Dual-Task Paradigms and Learning, Sonya E. Van Nuland
Theses/Dissertations from 2016
The Differential Effects of Connexin26 and Connexin43 in Modulating Epidermal Health in Response to UV Injury, Katanya C. Alaga
The Role of Forebrain Cholinergic Signalling In Regulating Hippocampal Function And Neuropathology, Mohammed Al-Onaizi
The Role of Cholinergic Neurotransmission in Sensory Filtering and Sensorimotor Gating, Erin Azzopardi
Establishing an In Vivo Model for Intratumoral Modulation Therapy for Glioblastoma Multiforme, Mitchell D. Cooper
Sensory Filtering and Cognitive Function in a Valproic Acid Rat Model of Autism, Theshani A. De Silva
Comprehensive Molecular Characterization of Human NODAL, Scott D. Findlay
The Behavioural Phenotype of pThr175-Tau Expression in the Hippocampus of Female Adult Sprague Dawley Rats, Jason J. Gopaul
Angiogenic Therapy in a Fibrotic Murine Model of Duchenne Muscular Dystrophy, Kelly M. Gutpell
Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice, Meghan L. Jelen
Panx1 and Panx3 regulate adipocyte development and fat accumulation in vivo, Vanessa R. Lee
Exploring the regulation and function of epithelial-mesenchymal plasticity in ovarian cancer spheroids, Samah Rafehi
Behavioural Inflexibility And White Matter Inflammation In An Aged hAPP Rat With Subcortical Stroke, Aaron M. Regis
Oncolytic Virus Therapy for the Treatment of Metastatic Ovarian Cancer, Jessica Tong
Investigating Stromal Contributions to the Regulation of Cancer Progression, Krista M. Vincent