Medical Biophysics Theses and Dissertations

 

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Theses/Dissertations from 2017

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Characterization of an 18F-Growth Hormone Secretagogue Probe for Positron Emission Tomography Imaging of the Growth Hormone Secretagogue Receptor, Ahmed Abbas, Master of Science, Supervisor: Savita Dhanvantari

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Using Computed Tomography Perfusion to Evaluate the Blood-Brain-Barrier and Blood-Tumor-Barrier Response following Focused Ultrasound Sonication with Microbubble Administration, Hassaan Ahmed, Doctor of Philosophy, Supervisor: Dr. Ting Lee

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Angiogenesis And Neo-Microcirculatory Function In Diseased Tissue Revealed By Intravital Microscopy, Giovanni-Michele Arpino, Doctor of Philosophy, Supervisor: Dr. J Geoffrey Pickering

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Novel Determinants of Smooth Muscle Cell-Based Vascular Integrity, Brittany N. Balint, Doctor of Philosophy, Supervisor: Dr. J. Geoffrey Pickering

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Therapeutic Application of Carbon Monoxide in Acute Limb Compartment Syndrome, Aurelia Bihari, Doctor of Philosophy, Supervisor: Dr Gediminas Cepinskas

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Design of Radio-Frequency Arrays for Ultra-High Field MRI, Ian R O Connell, Doctor of Philosophy, Supervisor: Professor Ravi Menon, Ph.D.

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Determining The Detective Quantum Efficiency (DQE) Of X-Ray Detectors In Clinical Environments, Terenz R. Escartin, Master of Science, Supervisor: Dr. Ian Cunningham

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Nicotinamide Riboside and the Aortic Response to Angiotensin II Infusion in Mice, Sina A. Ghoreishi, Master of Science, Supervisor: Dr. J. Geoffrey Pickering

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Tools for improving high-dose-rate prostate cancer brachytherapy using three-dimensional ultrasound and magnetic resonance imaging, William T. Hrinivich, Doctor of Philosophy, Supervisor: Eugene Wong

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A biomechanical approach for real-time tracking of lung tumors during External Beam Radiation Therapy (EBRT), Elham Karami, Doctor of Philosophy, Supervisor: Abbas Samani

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3D Ultrasound in the Management of Post Hemorrhagic Ventricle Dilatation, Jessica Kishimoto, Doctor of Philosophy, Supervisor: Sandrine de Ribaupierre

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Real-time membrane puncture detection using force sensors for micro-injections in phantoms, Szymon Kowal, Master of Science, Supervisor: James Lacefield

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In Vivo Magnetic Resonance Imaging Morphometry Measurements of Pulmonary Airspace Enlargement, Eric J. Lessard, Master of Science, Supervisor: Grace Parraga

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First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates, Matthew R. Lowerison, Doctor of Philosophy, Supervisor: Dr. James C. Lacefield

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Quantification of Cerebral Blood Flow and Oxidative Metabolism in Infants with Post-Hemorrhagic Ventricular Dilatation, Peter McLachlan, Master of Science, Supervisor: Dr. Keith St Lawrence

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Developments in PET-MRI for Radiotherapy Planning Applications, John Christian Patrick, Doctor of Philosophy, Supervisor: Dr. Stewart Gaede

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The Design, Fabrication, and Characterization of Nanoparticle-Protein Interactions for Theranostic Applications, Wai Hei Tse, Doctor of Philosophy, Supervisor: Dr. Jin Zhang

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Automated Vascular Smooth Muscle Segmentation, Reconstruction, Classification and Simulation on Whole-Slide Histology, Yiwen Xu, Doctor of Philosophy, Supervisor: Aaron D. Ward

Theses/Dissertations from 2016

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Comprehensive Topological, Geometric, And Hemodynamic Analysis Of The Rat Gluteus Maximus Arteriolar Networks, Mohammed K. Al Tarhuni, Master of Science, Supervisor: Dwayne N. Jackson

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Assessment of Post-Treatment Imaging Changes Following Radiotherapy using Magnetic Susceptibility Techniques, Jean-Guy Belliveau, Doctor of Philosophy, Supervisor: Ravi Menon

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Quantitative PET-CT Perfusion Imaging of Prostate Cancer, Adam R. Blais, Doctor of Philosophy, Supervisor: Ting-Yim Lee

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Energy Subtraction Methods as an Alternative to Conventional X-Ray Angiography, Christiane S. Burton, Doctor of Philosophy, Supervisor: Ian A. Cunningham

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Non-Invasive Imaging for the Assessment of Cardiac Dose and Function Following Focused External Beam Irradiation, Omar El-Sherif, Doctor of Philosophy, Supervisor: Dr. Stewart Gaede

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Arthrokinematics of the Distal Radioulnar Joint in the Normal Wrist and Following Distal Radius Malunion, Braden M. Gammon, Master of Science, Supervisor: Dr. Graham King

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Development and Optimization of 19F-MRI for Tracking Cellular Therapeutics, Jeffrey M. Gaudet, Doctor of Philosophy, Supervisor: Paula J. Foster

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Low Frequency Bio-Electrical Impedance Mammography and Dielectric Measurement, Seyyed Hesabgar, Doctor of Philosophy, Supervisor: Dr. Samani

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Measuring Brain Serine With Proton Magnetic Resonance Spectroscopy At 3.0 Tesla, Homa Javadzadeh, Master of Science, Supervisor: Dr. Jean Théberge

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Characterizing the Role of the Neuropeptide Y-Y5R System in Breast Cancer, Jenna Kara, Master of Science, Supervisor: Dr. Paula Foster

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Development of Anatomical and Functional Magnetic Resonance Imaging Measures of Alzheimer Disease, Samaneh Kazemifar, Doctor of Philosophy, Supervisor: Dr. Robert Bartha

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Optimizing the Rehabilitation of Elbow Lateral Collateral Ligament Injuries, Ranita Harpreet Kaur Manocha, Master of Science, Supervisor: Dr. Graham J. W. King

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Radiomics for Response Assessment after Stereotactic Radiotherapy for Lung Cancer, Sarah A. Mattonen, Doctor of Philosophy, Supervisor: Dr. Aaron Ward

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Magnetic Resonance Imaging of Breast Cancer Brain Metastasis Progression and Responses to Radiotherapy, Donna H. Murrell, Doctor of Philosophy, Supervisor: Dr. Paula Foster

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Static Magnetic Field Interactions of Medical Devices in The MRI Environment, Spencer Baird Parent, Master of Science, Supervisor: Dr. Blaine A. Chronik

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Hyperpolarized 3He Magnetic Resonance Imaging Phenotypes of Chronic Obstructive Pulmonary Disease, Damien Pike, Doctor of Philosophy, Supervisor: Dr. Grace Parraga

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Multi-Nuclear Magnetic Resonance Imaging of Obstructive Lung Disease, Khadija Sheikh, Doctor of Philosophy, Supervisor: Dr. Grace Parraga

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Digging Deeper with Diffuse Correlation Spectroscopy, Kyle J. Verdecchia, Doctor of Philosophy, Supervisor: Dr. Keith St. Lawrence

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Characterization of N-butyl Cyanoacrylate (NBCA) Glue Polymerization for the Embolization of Brain Arteriovenous Malformations (AVMs), Bill H. Wang, Master of Science, Supervisor: Dr. Stephen P. Lownie

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Optimizing Respiratory Gated Intensity Modulated Radiation Therapy Planning and Delivery of Early-Stage Non-Small Cell Lung Cancer, Ilma Xhaferllari, Doctor of Philosophy, Supervisor: Stewart Gaede

Theses/Dissertations from 2015

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Gait Analysis and Therapeutic Application of Carbon Monoxide in a Rodent Model of Complex Regional Pain Syndrome Type-1, Hussein Abdo, Master of Science, Supervisor: Dr. David Sanders

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Novel Techniques For Investigating The Regulation Of Skeletal Muscle Hemodynamics, Baraa K. Al-Khazraji, Doctor of Philosophy, Supervisor: Dr. Dwayne Jackson

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Mapping the Impact and Plasticity of Cortical-Cardiovascular Interactions in Vascular Disease Using Structural and Functional MRI, Udunna C. Anazodo, Doctor of Philosophy, Supervisor: Keith S St Lawrence

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Evaluation of novel salivary peptides and a new application method for prevention and treatment of oral disease, Tayebeh Basiri, Master of Science, Supervisor: Walter L. Siqueira

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Distal Humerus Hemiarthroplasty: Joint Kinematics, Stability, Congruency and Implant Design, Sagar J. Desai, Master of Science, Supervisor: Dr. Graham King

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Hyperpolarized 129Xe Magnetic Resonance Imaging of Radiation-Induced Lung Injury, Ozkan Doganay, Doctor of Philosophy, Supervisor: Giles Santyr

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Apodized-Aperture Pixel Design X-Ray Detector for Improvement of Detective Quantum Efficiency at High Spatial Frequencies, Elina Ismailova, Master of Science, Supervisor: Dr Ian Cunningham

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Development of a small animal conformal irradiator with dual energy x-ray computed tomography imaging for kilovoltage dosimetry, Michael D. Jensen, Doctor of Philosophy, Supervisor: Eugene Wong

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Towards Adaptive Radiotherapy through Development of Treatment Response Prediction, Anthony V. Lausch, Doctor of Philosophy, Supervisor: Dr. Eugene Wong

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Three-Dimensional Computed Tomography Measurements of Pulmonary Artery Volumes: Development and Application, Tamas J. Lindenmaier, Master of Science, Supervisor: Dr. Grace Parraga

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Characterization of Maga Expression and Iron Uptake in P19 Cells: Implications for Use as a Gene-Based Contrast Agent, Linshan Liu, Master of Science, Supervisor: Donna Goldhawk

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Intracellular Acidification in Brain Tumors Induced by Topiramate : In-Vivo Detection Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Kamini Y. Marathe, Master of Science, Supervisor: Dr. Robert Bartha

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Laminar fMRI in Auditory Cortex at 7T, Jacob JL Matthews, Master of Science, Supervisor: Dr. Rhodri Cusack

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Blood Supply to the Brain via the Carotid Arteries: Examining Obstructive and Sclerotic Disorders using Theoretical and Experimental Models, Onaizah Onaizah, Master of Science, Supervisor: Dr. Mair Zamir

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Non-invasive Quantification of Alveolar Morphometry Measurements in Older Never-smokers, Gregory A. Paulin, Master of Science, Supervisor: Dr. Grace Parraga

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Investigation of Endogenous In-Vivo Sodium Concentration in Human Prostate Cancer Measured With 23Na Magnetic Resonance Imaging, Justin C. Peterson, Master of Science, Supervisor: Timothy Scholl

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Towards the Development of a MagA Reporter Gene Expression Construct for Magnetic Resonance Imaging, Karina Quiaoit, Master of Science, Supervisor: Donna Goldhawk

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Estimating Hemodynamics in Skeletal Muscle Arteriolar Networks Reconstructed From In Vivo Data, Amani H. Saleem, Master of Science, Supervisor: Dr. Daniel Goldman

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The Kinetics of Cystatin C: A Marker for Dialysis Adequacy, Huang S. Shih-Han, Doctor of Philosophy, Supervisor: Dr. Robert Lindsay

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The Development and Validation of a Molecular Imaging Probe Targeted to Cathepsin D for the In-vivo Detection of Alzheimer Disease, Jonatan Snir, Doctor of Philosophy, Supervisor: Drs. Robert Bartha

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Feasibility of using Arterial Spin Labeling for Detecting Longitudinal Changes in Cerebral Blood Flow, Tracy Ssali, Master of Science, Supervisor: Dr Keith St Lawrence

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Pulmonary Imaging to Better Understand Asthma, Sarah Svenningsen, Doctor of Philosophy, Supervisor: Grace Parraga

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Resting and Functional Magnetic Resonance Spectroscopy of Glutamate in Schizophrenia at 7 Tesla, Reggie E. Taylor, Doctor of Philosophy, Supervisor: Dr. Jean Théberge

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Role of Cerebrovascular Abnormality in Neurodegenerative Disease and Subcortical Ischemic Disease: CT Perfusion and PET Imaging, Jun Yang, Doctor of Philosophy, Supervisor: Ting-Yim Lee

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Novel protective salivary peptides and the chitosan nanoparticles delivery system, Flavia Zaidan Cardoso Salina, Master of Science, Supervisor: Dr. Walter Luiz Siqueira

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Evaluation of Radiation Dose-Response in a Breast Cancer Brain Metastasis Model, Niloufar Zarghami, Master of Science, Supervisor: Dr. Eugene Wong

Theses/Dissertations from 2014

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The Repair, Reconstruction and Replacement of the Coronoid Process, Bashar Alolabi, Master of Science, Supervisor: Dr. Graham King

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Towards Stem Cell Treatment for Duchenne Muscular Dystrophy-Related Cardiomyopathy, Bogdan A. Bondoc, Master of Science, Supervisor: Lisa Hoffman

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Advances in image acquisition and filtering for MRI neuroimaging at 7 tesla, Andrew T. Curtis, Doctor of Philosophy, Supervisor: Dr. Ravi Menon

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Reinforcement of Flowable Dental Composites with Titanium Dioxide Nanotubes, Manal Dafar, Master of Science, Supervisor: Dr. Amin Rizkalla

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Nasopharyngeal method for selective brain cooling and development of a time-resolved near-infrared technique to monitor brain temperature and oxidation status during hypothermia, Mohammad Fazel Bakhsheshi, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee

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Metabolic Correlates in Spinal Cord Compression Measured by Magnetic Resonance Spectroscopy in the Motor and Sensory Cortices, Sandy Goncalves, Master of Science, Supervisor: Dr. Neil Duggal

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Novel Mechanisms In The Sorting Of Proglucagon To The Secretory Granules Of The Regulated Secretory Pathway, Leonard M. Guizzetti, Doctor of Philosophy, Supervisor: Dr. Savita Dhanvantari

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Intensity Based Non-rigid Registration of 3D Whole Mouse Optical and MR Image Volumes, Jacqueline Kathleen Harris, Master of Science, Supervisor: Dr. Charles McKenzie

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The Development of a Digital X-ray Imaging System for The Characterization of Transmission of Whole-Body Vibration in Mice, Zhengyi Hu, Master of Science, Supervisor: David W. Holdsworth

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Investigating Cortical Changes in Cervical Spondylotic Myelopathy Using Functional Magnetic Resonance Imaging, Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging, Izabela Kowalczyk, Doctor of Philosophy, Supervisor: Dr. Robert Bartha

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The Development and Application of a Forearm Simulator to Investigate Radial Head Biomechanics, Brent A. Lanting, Master of Science, Supervisor: Graham King

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Pathophysiology of Compartment Syndrome, Abdel-Rahman Lawendy, Doctor of Philosophy, Supervisor: Gediminas Cepinskas

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Quantitative Analysis of Relaxation Rate Dependence on Interecho Time in MagA-expressing, Iron-labeled Cells, Casey Yesol Lee, Master of Science, Supervisor: Dr. Neil Gelman

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Ultra High Field (7T) Magnetic Resonance Imaging of Intracranial Vessel Wall, Pablo Lopez-Ojeda, Master of Science, Supervisor: Dr. Mel Boulton

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Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity, Kathryn Y. Manning, Master of Science, Supervisor: Dr. Ravi Menon

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Fully Automated Segmentation and Quantification of Abdominal Adipose Tissue Compartments in Mouse MRI, Colin M. McCurdy, Master of Science, Supervisor: Charles McKenzie

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Temperature and pH Imaging using Chemical Exchange Saturation Transfer (CEST) MRI Contrast, Nevin Neil Campbell McVicar, Doctor of Philosophy, Supervisor: Dr. Robert Bartha

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Pre-diabetes and sympathetic nervous system mediated microvascular dysregulation in skeletal muscle, Nicole M. Novielli, Doctor of Philosophy, Supervisor: Dr. Dwayne Jackson

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Dual energy imaging for determining urinary calculi composition: A theoretical and experimental study with computed tomography, Stephanie Nykamp, Master of Science, Supervisor: Dr. Ian Cunningham

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A Non-Contrast Magnetic Resonance Imaging Technique to Assess Blood-Brain Barrier Permeability, Harini Pandithasekera, Master of Science, Supervisor: Dr. Keith St. Lawrence

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Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease, Jacob Penner, Doctor of Philosophy, Supervisor: Robert Bartha

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Investigation of Techniques to increase the Field of View of a Staring Transducer Array for Photoacoustic Imaging, Avery Raess, Master of Science, Supervisor: Dr. Jeffrey Carson

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MRI Relaxation Rates: A Quantitative Approach to Track Tumour Cells Expressing MagA, Anindita Sengupta, Master of Science, Supervisor: Dr. Neil Gelman

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Multiparametric Imaging and MR Image Texture Analysis in Brain Tumors, Harish A. Sharma, Doctor of Philosophy, Supervisor: Dr. Robert Bartha

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Potential for Photoacoustic Imaging of Neonatal Brain, Pantea Tavakolian, Master of Science, Supervisor: Dr. Jeffrey Carson

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The Effect of Diffusive and Convective Sodium Balance During Hemodialysis on Interdialytic Weight Gain, Benjamin Thomson, Master of Science, Supervisor: Dr. Robert Lindsay

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A Pseudo Non-Cartesian Pulse Sequence For Hyperpolarized Xenon-129 Gas MRI of Rodent Lungs At Low Magnetic Field Strength, Krzysztof Wawrzyn, Master of Science, Supervisor: Giles Edmund Santyr

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Three-dimensional Photoacoustic Tomography System Design Analysis and Optimization, Philip Wong, Master of Science, Supervisor: Dr. Jeffrey J.L. Carson

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Functional Imaging of Malignant Gliomas with CT Perfusion, Timothy Pok Chi Yeung, Doctor of Philosophy, Supervisor: Drs. Glenn Bauman

Theses/Dissertations from 2013

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Delta Relaxation Enhanced Magnetic Resonance - Development and Application of a Field-Cycling Contrast Mechanism, Yonathan Araya, Master of Science, Supervisor: Dr. Timothy Scholl

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Effects of a Power-Line Frequency Magnetic Field on Human Cognitive Processing, Michael Corbacio, Master of Science, Supervisor: Dr Alexandre Legros

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Complex Shoulder Instability: The Role of the Latarjet Coracoid Transfer, Ryan Degen, Master of Science, Supervisor: Dr. Jim Johnson

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Improving Acute Stroke Management with CT Perfusion Imaging: Approaches to Treatment Guidance and Brain Tissue Salvage, Christopher D. d'Esterre, Doctor of Philosophy, Supervisor: Dr. Ting-Yim Lee

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The Impact of Lateral Electron Disequilibrium on Stereotactic Body Radiation Therapy of Lung Cancer, Brandon Disher, Doctor of Philosophy, Supervisor: Dr. Jerry J. Battista

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Imaging Breast Cancer Progression and Lymph Node Metastases in Murine Models Using MRI and Magnetic Nanoparticles, Vasiliki Economopoulos, Doctor of Philosophy, Supervisor: Dr. Paula Foster

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On The Development of a Dynamic Contrast-Enhanced Near-Infrared Technique to Measure Cerebral Blood Flow in the Neurocritical Care Unit, Jonathan T. Elliott, Doctor of Philosophy, Supervisor: Keith St. Lawrence