Investigating the role of RXRα in spine development of embryonic mice
Faculty
Science
Supervisor Name
Dr. Cheryle Séguin
Keywords
spine development, intervertebral disc, RXRα
Description
My project is about using a mouse model to investigate the role of the RXRα gene in spine health. I used histology techniques to prepare and analyze samples of wild type and knockout mice (e.g. sectioning, staining and imaging slides, etc.). Embryonic mice were used to investigate how development of the spine at early stages is affected by the presence or absence of the gene. We hope to determine the role of RXRα in spine development to see if it would be an effective target for therapeutics for disc degeneration.
Acknowledgements
Thank you to Dr. Cheryle Séguin, the Western USRI Program, and the Department of Physiology and Pharmacology.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Document Type
Video
Investigating the role of RXRα in spine development of embryonic mice
My project is about using a mouse model to investigate the role of the RXRα gene in spine health. I used histology techniques to prepare and analyze samples of wild type and knockout mice (e.g. sectioning, staining and imaging slides, etc.). Embryonic mice were used to investigate how development of the spine at early stages is affected by the presence or absence of the gene. We hope to determine the role of RXRα in spine development to see if it would be an effective target for therapeutics for disc degeneration.