Efect of 25 weeks probiotic supplementation on immune function of HIV patients

Authors

Jacquelyn L. Hill, The University of Western Ontario
M. Karen Campbell, The University of Western Ontario
Guang Yong Zou, The University of Western Ontario
John R.G. Challis, University of Toronto
Gregor Reid, The University of Western Ontario
Hiroshi Chisaka, University of Toronto
Alan D. Bocking, University of Toronto

Document Type

Article

Publication Date

1-1-2008

Journal

American Journal of Obstetrics and Gynecology

Volume

198

Issue

4

First Page

468.e1

Last Page

468.e9

URL with Digital Object Identifier

10.1016/j.ajog.2008.01.007

Abstract

Objective: The objective of the study was to use recursive partitioning (RP) to identify gestational age-specific and threshold values for infectious and endocrine biomarkers of imminent delivery. Study Design: RP was developed using a previously collected data set and then applied to a prospectively collected cohort of women in threatened preterm labor. Predictors of preterm birth were considered, including white blood cell count (WBC), corticotrophin-releasing hormone (CRH), cortisol, and maternal age. Results: At 22-27 weeks' gestation, WBC of greater than 12,000/mL was the most accurate predictor of delivery within 48 hours; at 28-31 weeks' gestation, CRH of greater than 684 pg/mL was the most accurate predictor; and at 32-26 weeks' gestation, CRH and maternal age were the most important variables. Conclusions: These results indicate that maternal WBC greater than 12,000/mL prior to 28 weeks' gestation and CRH beyond 28 weeks are the most accurate biomarkers in predicting preterm birth within 48 hours. RP assists in establishing clinically relevant and gestational age-specific threshold levels for these variables. © 2008 Mosby, Inc. All rights reserved.