Bone and Joint Institute
The Bone and Joint Institute positions Western as a global leader in research and innovation in musculoskeletal health. With over 145 members, the Institute brings together a critical mass of experts across disciplines to achieve high-impact transdisciplinary research for the benefit of millions of Canadians suffering from pain and reduced mobility.
Visit the Bone and Joint Institute website for additional information.
Browse The Bone and Joint Institute Publications
Submissions from 2014
Structure-property relationships for a series of poly(ester amide)s containing amino acids, Abdolrasoul Soleimani, Stephan Drappel, Rina Carlini, Adela Goredema, and Elizabeth R. Gillies
Cleaving C-H bonds with hyperthermal H2: Facile chemistry to cross-link organic molecules under low chemical- and energy-loads, Tomas Trebicky, Patrick Crewdson, Maxim Paliy, Igor Bello, Heng Yong Nie, Zhi Zheng, Xiaoli Fan, Jun Yang, Elizabeth R. Gillies, Changyu Tang, Hao Liu, K. W. Wong, and W. M. Lau
Analysis of chondrogenesis using micromass cultures of limb mesenchyme, T. Michael Underhill, Helen J. Dranse, and Lisa M. Hoffman
Development and Performance Evaluation of a Multi-PID Muscle Loading Driven in Vitro Active-Motion Shoulder Simulator and Application to Assessing Reverse Total Shoulder Arthroplasty, Joshua William Giles, Louis Miguel Ferreira, George Singh Athwal, and James Andrew Johnson
The effect of implant design of linked total elbow arthroplasty on stability and stress: A finite element analysis, Ryan Willing, Graham J.W. King, and James A. Johnson
In vitro assessment of the contact mechanics of reverse-engineered distal humeral hemiarthroplasty prostheses, Ryan Willing, Michael Lapner, Graham J.W. King, and James A. Johnson
Development of a computational technique to measure cartilage contact area, Ryan Willing, Michael Lapner, Emily A. Lalone, Graham J.W. King, and James A. Johnson
Evaluation of a computational model to predict elbow range of motion, Ryan T. Willing, Masao Nishiwaki, James A. Johnson, Graham J.W. King, and George S. Athwal
Multiresponsive azobenzene end-cap for self-immolative polymers, Andrew D. Wong, Thomas M. Güngör, and Elizabeth R. Gillies
Improving quantitative CT perfusion parameter measurements using principal component analysis, Timothy Pok Chi Yeung, Mark Dekaban, Nathan De Haan, Laura Morrison, Lisa Hoffman, Yves Bureau, Xiaogang Chen, Slav Yartsev, Glenn Bauman, and Ting Yim Lee
CT Perfusion Imaging as an Early Biomarker of Differential Response to Stereotactic Radiosurgery in C6 Rat Gliomas, Timothy Pok Chi Yeung, Maher Kurdi, Yong Wang, Baraa Al-Khazraji, Laura Morrison, Lisa Hoffman, Dwayne Jackson, Cathie Crukley, Ting-Yim Lee, Glenn Bauman, and Slav Yartsev
Is ORIF superior to nonoperative treatment in isolated displaced partial articular fractures of the radial head?, Albert Yoon, Graham J.W. King, and Ruby Grewal
Submissions from 2013
Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients, Lillian Barra, Mathias Scinocca, Sheri Saunders, Rajesh Bhayana, Sherry Rohekar, Maud Racapé, Robert Coles, Ewa Cairns, and David A. Bell
A magnetic-resonance-imaging-compatible remote catheter navigation system., Mohammad Ali Tavallaei, Yogesh Thakur, Syed Haider, and Maria Drangova
It begins with the right supervisor: Importance of mentorship and clinician-investigator trainee satisfaction levels in Canada, Ju Yoon Yoon, Tom Appleton, Matthew J. Cecchini, Rohann J. Correa, Veronique D. Ram, Xin Wang, Enoch Ng, Mark Speechley, and Jared T. Wilcox
Submissions from 2012
Reply, Andrew J. Kinloch, Saba Alzabin, Natalia Wegner, William Brintnell, Elizabeth Wilson, Lillian Barra, David A. Bell, Ewa Cairns, and Patrick J. Venables
Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis, Shirine E. Usmani, C. Thomas G. Appleton, and Frank Beier
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist, Kyle M. Walker, Mateusz Rytelewski, Delfina M. Mazzuca, Shannon A. Meilleur, Lisa A. Mannik, David Yue, William C. Brintnell, Ian Welch, Ewa Cairns, and S. M.Mansour Haeryfar
Submissions from 2011
Immunization with porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice, Andrew J. Kinloch, Saba Alzabin, William Brintnell, Elizabeth Wilson, Lillian Barra, Natalia Wegner, David A. Bell, Ewa Cairns, and Patrick J. Venables
Submissions from 2010
Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation, C. Thomas G. Appleton, Shirine E. Usmani, John S. Mort, and Frank Beier
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis, Altan Ercan, Jing Cui, Dereck E.W. Chatterton, Kevin D. Deane, Melissa M. Hazen, William Brintnell, Colin I. O'Donnell, Lezlie A. Derber, Michael E. Weinblatt, Nancy A. Shadick, David A. Bell, Ewa Cairns, Daniel H. Solomon, V. Michael Holers, Pauline M. Rudd, and David M. Lee
CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice, David Yue, William Brintnell, Lisa A. Mannik, Darah A. Christie, S. M.Mansour Haeryfar, Joaquín Madrenas, Subrata Chakrabarti, David A. Bell, and Ewa Cairns
Submissions from 2009
Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering, Andrew J.E. Appleton, C. Thomas G. Appleton, Derek R. Boughner, and Kem A. Rogers
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-β activation, Mukundan G. Attur, Glyn D. Palmer, Hayf E. Al-Mussawir, Mandar Dave, Cristina C. Teixeira, Daniel B. Rifkin, C. Thomas G. Appleton, Frank Beier, and Steven B. Abramson
The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli, Denise L. Cecil, C. Thomas G. Appleton, Monika D. Polewski, John S. Mort, Ann Marie Schmidt, Alison Bendele, Frank Beier, and Robert Terkeltaub
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome, Thu A. Chau, Michelle L. McCully, William Brintnell, Gary An, Katherine J. Kasper, Enrique D. Vinés, Paul Kubes, S. M.Mansour Haeryfar, John K. McCormick, Ewa Cairns, David E. Heinrichs, and Joaquín Madrenas
Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin, J. L. Hayworth, K. J. Kasper, M. Leon-Ponte, C. A. Herfst, D. Yue, W. C. Brintnell, D. M. Mazzuca, D. E. Heinrichs, E. Cairns, J. Madrenas, D. W. Hoskin, J. K. McCormick, and S. M.M. Haeryfar
Association of severe inflammatory polyarthritis in primary Sjögren's syndrome: Clinical, serologic, and HLA analysis, Khulood Mohammed, Janet Pope, Nicole Le Riche, William Brintnell, Ewa Cairns, Robert Coles, and David A. Bell
Submissions from 2008
Erratum: Correction: Forced mobilization accelerates pathogenesis: Characterization of a preclinical surgical model of osteoarthritis (Arthritis Research and Therapy) 2008 vol. 10 (407), C. Thomas G. Appleton, David D. McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M. Bernier, James L. Henry, David W. Holdsworth, and Frank Beier
An intriguing relationship between the immune response to citrullinated vimentin and the HLA shared epitope: Comment on the article by Verpoort et al, David A. Bell, Jonathan A. Hill, and Ewa Cairns
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice, Jonathan A. Hill, David A. Bell, William Brintnell, David Yue, Bret Wehrli, Anthony M. Jevnikar, David M. Lee, Wolfgang Hueber, William H. Robinson, and Ewa Cairns
Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography, D. D. McErlain, C. T.G. Appleton, R. B. Litchfield, V. Pitelka, J. L. Henry, S. M. Bernier, F. Beier, and D. W. Holdsworth
Submissions from 2007
Global analyses of gene expression in early experimental osteoarthritis, C. T.G. Appleton, V. Pitelka, J. Henry, and F. Beier
Molecular and histological analysis of a new rat model of experimental knee osteoarthritis, C. Thomas G. Appleton, David D. McErlain, James L. Henry, David W. Holdsworth, and Frank Beier
Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis, C Thomas G Appleton, David D McErlain, Vasek Pitelka, and Neil Schwartz
The influence of MHC class II molecules containing the rheumatoid arthritis shared epitope on the immune response to aggrecan G1 and its peptides, W. Brintnell, D. A. Bell, J. A. Hill, A. M. Jevnikar, A. Sette, J. Sidney, K. Doege, and E. Cairns
Severe necrotizing pancreatitis following combined hepatitis A and B vaccination, Eran Shlomovitz, Ward Davies, Ewa Cairns, William C. Brintnell, Mark Goldszmidt, and George K. Dresser
Submissions from 2006
Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation, C. Thomas G. Appleton, Claudine G. James, and Frank Beier
Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis, Jonathan A. Hill, Jamal Al-Bishri, Dafna D. Gladman, Ewa Cairns, and David A. Bell
Submissions from 2005
Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy, Claudine G. James, C. Thomas G. Appleton, Veronica Ulici, T. Michael Underhill, and Frank Beier
Giving credit where credit is due: John Hunter and the discovery of erythrocyte sedimentation rate, Joaquín Madrenas, Paul Potter, and Ewa Cairns
Submissions from 2004
The joy of citrulline: New insights into the diagnosis, pathogenesis, and treatment of rheumatoid arthritis, Jonathan Hill, Ewa Cairns, and David A. Bell
Submissions from 2003
Erratum: Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA (Journal of Immunology (2003) 171 (691-696)), Jonathan A. Hill, Thomas E. Ichim, Kornel P. Kusznieruk, Mu Li, Xuyan Huang, Xiaotao Yan, Robert Zhong, Ewa Cairns, David A. Bell, and Wei Ping Min
Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA, Jonathan A. Hill, Thomas E. Ichim, Kornel P. Kusznieruk, Mu Li, Xuyan Huang, Xiaotao Yan, Robert Zhong, Ewa Cairns, David A. Bell, and Wei Ping Min
Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule, Jonathan A. Hill, Scott Southwood, Alessandro Sette, Anthony M. Jevnikar, David A. Bell, and Ewa Cairns
The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse model., Jonathan A. Hill, Dequn Wang, Anthony M. Jevnikar, Ewa Cairns, and David A. Bell
Submissions from 2002
The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice, Dequn Wang, Jonathan A. Hill, Ewa Cairns, and David A. Bell
Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice, Dequn Wang, Jonathan A. Hill, Anthony M. Jevnikar, Ewa Cairns, and David A. Bell
Submissions from 1997
V region gene analysis of human IgM hybridoma monoclonal anti-Sm antibodies, M. Mahmoudi, J. Y. Edwards, D. A. Bell, and E. Cairns
Submissions from 1995
Defective antigen-receptor-mediated regulation of immunoglobulin production in B cells from autoimmune strains of mice, Colin C. Anderson, Ewa Cairns, Ulrich H. Rudofsky, and Nicholas R.C. Sinclair
Immunoglobulin gene sequence anlaysis of anti-cardiolipin and anti-cardiolipin idiotype (h3) human monoglonal antibodies, Arthur Hohmann, Ewa Cairns, Michael Brisco, David A. Bell, and Betty Diamond
The role of the immunoglobulin heavy chain in human anti‐dna antibody binding specificity, Ahmoud Mahmoudi, Gregory A. Denomme, Jane Y. Edwards, David A. Bell, and Ewa Cairns
The Importance of the Diversity Region YYGS Motif in Anti‐DNA Antibody Binding to DNA, MAHMOUD MAHMOUDI, DAVID A. BELL, and EWA CAIRNS
Nonsynonymous mutations in an Fc-receptor structural gene in NZB mice, Dennis J. Sawchuk, Mahmoud Mahmoudi, Ewa Cairns, and Nicholas R.St C. Sinclair
Submissions from 1994
Immunoglobulin V Sequences of Two Human Antiplatelet Monoclonal Autoantibodies Derived from B Cells of Normal Origin, Gregory A. Denomme, Mahmoud Mahmoudi, Ewa Cairns, and David A. Bell
Submissions from 1993
Immunoglobulin V region heavy and light chain gene sequences of the lymphoblastoid cell line GM 4672, Gregory A. Denomme, Mahmoud Mahmoudi, Jane Y. Edwards, Hélène Massicotte, Ewa Cairns, and David A. Bell
Submissions from 1992
An inter-laboratory idiotype assay validation study., E. Cairns, S. Andrejchyshyn, and J. Rauch
Submissions from 1990
Comparative study of idiotypes on monoclonal antibodies derived from patients with lupus and leprosy and from normal individuals, C. G. Mackworth-Young, E. Cairns, J. Sabbaga, H. Massicotte, B. Diamond, and R. S. Schwartz
A human anti-cardiolipin autoantibody is encoded by developmentally restricted heavy and light chain variable region genes, Katherine A. Siminovitch, Virginia Misener, Pak C. Kwong, Pei Ming Yang, Carl A. Laskin, Ewa Cairns, David Bell, Laurence A. Rubin, and Pojen P. Chen
Submissions from 1989
Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses, E. Cairns, P. C. Kwong, V. Misener, P. Ip, D. A. Bell, and K. A. Siminovitch
Expression in systemic lupus erythematosus of an idiotype common to DNA-binding and nonbinding monoclonal antibodies produced by normal human lymphoid cells, E. Cairns, H. Massicotte, and D. A. Bell
Submissions from 1987
Antinucleic acid autoantibody responses of normal human origin: antigen specificity and idiotypic characteristics compared to patients with systemic lupus erythematosus and patients with monoclonal IgM., D. A. Bell, E. Cairns, K. Cikalo, V. Ly, J. Block, and W. Pruzanski
Submissions from 1986
Cytoskeletal binding of monoclonal anti‐dna antibodies derived from tonsillar lymphoid cells of a normal subject, EWA Cairns, Ronald Komar, and David A. Bell
Submissions from 1985
The in vitro production of anti-DNA antibody by cultured peripheral blood of tonsillar lymphoid cells from normal donors and SLE patients, E. Cairns, J. St. Germain, and D. A. Bell
Submissions from 1984
A comparison of serologic reactivity among SLE patients with or without anti-Ro (SS-A) antibodies, D. A. Bell, R. Komar, W. B. Chodirker, J. Block, and E. Cairns
Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell origin, E. Cairns, J. Block, and D. A. Bell
Submissions from 1983
Immunoregulation in rheumatoid arthritis: Evaluation of T lymphocyte function in the control of polyclonal immunoglobulin synthesis in vitro, N. Bellamy, E. Cairns, and D. A. Bell
Submissions from 1980
Peanut and horse radish peroxidase isoenzymes. Intraspecies and interspecies immunological relatedness, EWA CAIRNS, ROBERT B.VAN HUYSTEE, and WILLIAM L. CAIRNS