Bone and Joint Institute

 

The Bone and Joint Institute positions Western as a global leader in research and innovation in musculoskeletal health. With over 145 members, the Institute brings together a critical mass of experts across disciplines to achieve high-impact transdisciplinary research for the benefit of millions of Canadians suffering from pain and reduced mobility.

Visit the Bone and Joint Institute website for additional information.

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Submissions from 2014

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Photodegradable poly(ester amide)s for indirect light-triggered release of paclitaxel, Abdolrasoul Soleimani, Aneta Borecki, and Elizabeth R. Gillies

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Structure-property relationships for a series of poly(ester amide)s containing amino acids, Abdolrasoul Soleimani, Stephan Drappel, Rina Carlini, Adela Goredema, and Elizabeth R. Gillies

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Cleaving C-H bonds with hyperthermal H2: Facile chemistry to cross-link organic molecules under low chemical- and energy-loads, Tomas Trebicky, Patrick Crewdson, Maxim Paliy, Igor Bello, Heng Yong Nie, Zhi Zheng, Xiaoli Fan, Jun Yang, Elizabeth R. Gillies, Changyu Tang, Hao Liu, K. W. Wong, and W. M. Lau

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Analysis of chondrogenesis using micromass cultures of limb mesenchyme, T. Michael Underhill, Helen J. Dranse, and Lisa M. Hoffman

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Development and Performance Evaluation of a Multi-PID Muscle Loading Driven in Vitro Active-Motion Shoulder Simulator and Application to Assessing Reverse Total Shoulder Arthroplasty, Joshua William Giles, Louis Miguel Ferreira, George Singh Athwal, and James Andrew Johnson

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The effect of implant design of linked total elbow arthroplasty on stability and stress: A finite element analysis, Ryan Willing, Graham J.W. King, and James A. Johnson

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In vitro assessment of the contact mechanics of reverse-engineered distal humeral hemiarthroplasty prostheses, Ryan Willing, Michael Lapner, Graham J.W. King, and James A. Johnson

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Development of a computational technique to measure cartilage contact area, Ryan Willing, Michael Lapner, Emily A. Lalone, Graham J.W. King, and James A. Johnson

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Evaluation of a computational model to predict elbow range of motion, Ryan T. Willing, Masao Nishiwaki, James A. Johnson, Graham J.W. King, and George S. Athwal

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Multiresponsive azobenzene end-cap for self-immolative polymers, Andrew D. Wong, Thomas M. Güngör, and Elizabeth R. Gillies

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Improving quantitative CT perfusion parameter measurements using principal component analysis, Timothy Pok Chi Yeung, Mark Dekaban, Nathan De Haan, Laura Morrison, Lisa Hoffman, Yves Bureau, Xiaogang Chen, Slav Yartsev, Glenn Bauman, and Ting Yim Lee

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CT Perfusion Imaging as an Early Biomarker of Differential Response to Stereotactic Radiosurgery in C6 Rat Gliomas, Timothy Pok Chi Yeung, Maher Kurdi, Yong Wang, Baraa Al-Khazraji, Laura Morrison, Lisa Hoffman, Dwayne Jackson, Cathie Crukley, Ting-Yim Lee, Glenn Bauman, and Slav Yartsev

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Is ORIF superior to nonoperative treatment in isolated displaced partial articular fractures of the radial head?, Albert Yoon, Graham J.W. King, and Ruby Grewal

Submissions from 2013

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Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients, Lillian Barra, Mathias Scinocca, Sheri Saunders, Rajesh Bhayana, Sherry Rohekar, Maud Racapé, Robert Coles, Ewa Cairns, and David A. Bell

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A magnetic-resonance-imaging-compatible remote catheter navigation system., Mohammad Ali Tavallaei, Yogesh Thakur, Syed Haider, and Maria Drangova

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It begins with the right supervisor: Importance of mentorship and clinician-investigator trainee satisfaction levels in Canada, Ju Yoon Yoon, Tom Appleton, Matthew J. Cecchini, Rohann J. Correa, Veronique D. Ram, Xin Wang, Enoch Ng, Mark Speechley, and Jared T. Wilcox

Submissions from 2012

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Reply, Andrew J. Kinloch, Saba Alzabin, Natalia Wegner, William Brintnell, Elizabeth Wilson, Lillian Barra, David A. Bell, Ewa Cairns, and Patrick J. Venables

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Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis, Shirine E. Usmani, C. Thomas G. Appleton, and Frank Beier

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Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist, Kyle M. Walker, Mateusz Rytelewski, Delfina M. Mazzuca, Shannon A. Meilleur, Lisa A. Mannik, David Yue, William C. Brintnell, Ian Welch, Ewa Cairns, and S. M.Mansour Haeryfar

Submissions from 2011

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Immunization with porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice, Andrew J. Kinloch, Saba Alzabin, William Brintnell, Elizabeth Wilson, Lillian Barra, Natalia Wegner, David A. Bell, Ewa Cairns, and Patrick J. Venables

Submissions from 2010

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Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation, C. Thomas G. Appleton, Shirine E. Usmani, John S. Mort, and Frank Beier

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Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis, Altan Ercan, Jing Cui, Dereck E.W. Chatterton, Kevin D. Deane, Melissa M. Hazen, William Brintnell, Colin I. O'Donnell, Lezlie A. Derber, Michael E. Weinblatt, Nancy A. Shadick, David A. Bell, Ewa Cairns, Daniel H. Solomon, V. Michael Holers, Pauline M. Rudd, and David M. Lee

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CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice, David Yue, William Brintnell, Lisa A. Mannik, Darah A. Christie, S. M.Mansour Haeryfar, Joaquín Madrenas, Subrata Chakrabarti, David A. Bell, and Ewa Cairns

Submissions from 2009

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Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering, Andrew J.E. Appleton, C. Thomas G. Appleton, Derek R. Boughner, and Kem A. Rogers

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F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-β activation, Mukundan G. Attur, Glyn D. Palmer, Hayf E. Al-Mussawir, Mandar Dave, Cristina C. Teixeira, Daniel B. Rifkin, C. Thomas G. Appleton, Frank Beier, and Steven B. Abramson

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The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli, Denise L. Cecil, C. Thomas G. Appleton, Monika D. Polewski, John S. Mort, Ann Marie Schmidt, Alison Bendele, Frank Beier, and Robert Terkeltaub

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Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome, Thu A. Chau, Michelle L. McCully, William Brintnell, Gary An, Katherine J. Kasper, Enrique D. Vinés, Paul Kubes, S. M.Mansour Haeryfar, John K. McCormick, Ewa Cairns, David E. Heinrichs, and Joaquín Madrenas

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Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin, J. L. Hayworth, K. J. Kasper, M. Leon-Ponte, C. A. Herfst, D. Yue, W. C. Brintnell, D. M. Mazzuca, D. E. Heinrichs, E. Cairns, J. Madrenas, D. W. Hoskin, J. K. McCormick, and S. M.M. Haeryfar

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Association of severe inflammatory polyarthritis in primary Sjögren's syndrome: Clinical, serologic, and HLA analysis, Khulood Mohammed, Janet Pope, Nicole Le Riche, William Brintnell, Ewa Cairns, Robert Coles, and David A. Bell

Submissions from 2008

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Erratum: Correction: Forced mobilization accelerates pathogenesis: Characterization of a preclinical surgical model of osteoarthritis (Arthritis Research and Therapy) 2008 vol. 10 (407), C. Thomas G. Appleton, David D. McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M. Bernier, James L. Henry, David W. Holdsworth, and Frank Beier

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An intriguing relationship between the immune response to citrullinated vimentin and the HLA shared epitope: Comment on the article by Verpoort et al, David A. Bell, Jonathan A. Hill, and Ewa Cairns

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Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice, Jonathan A. Hill, David A. Bell, William Brintnell, David Yue, Bret Wehrli, Anthony M. Jevnikar, David M. Lee, Wolfgang Hueber, William H. Robinson, and Ewa Cairns

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Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography, D. D. McErlain, C. T.G. Appleton, R. B. Litchfield, V. Pitelka, J. L. Henry, S. M. Bernier, F. Beier, and D. W. Holdsworth

Submissions from 2007

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Global analyses of gene expression in early experimental osteoarthritis, C. T.G. Appleton, V. Pitelka, J. Henry, and F. Beier

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Molecular and histological analysis of a new rat model of experimental knee osteoarthritis, C. Thomas G. Appleton, David D. McErlain, James L. Henry, David W. Holdsworth, and Frank Beier

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Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis, C Thomas G Appleton, David D McErlain, Vasek Pitelka, and Neil Schwartz

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The influence of MHC class II molecules containing the rheumatoid arthritis shared epitope on the immune response to aggrecan G1 and its peptides, W. Brintnell, D. A. Bell, J. A. Hill, A. M. Jevnikar, A. Sette, J. Sidney, K. Doege, and E. Cairns

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Severe necrotizing pancreatitis following combined hepatitis A and B vaccination, Eran Shlomovitz, Ward Davies, Ewa Cairns, William C. Brintnell, Mark Goldszmidt, and George K. Dresser

Submissions from 2006

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Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation, C. Thomas G. Appleton, Claudine G. James, and Frank Beier

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Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis, Jonathan A. Hill, Jamal Al-Bishri, Dafna D. Gladman, Ewa Cairns, and David A. Bell

Submissions from 2005

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Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy, Claudine G. James, C. Thomas G. Appleton, Veronica Ulici, T. Michael Underhill, and Frank Beier

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Giving credit where credit is due: John Hunter and the discovery of erythrocyte sedimentation rate, Joaquín Madrenas, Paul Potter, and Ewa Cairns

Submissions from 2004

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The joy of citrulline: New insights into the diagnosis, pathogenesis, and treatment of rheumatoid arthritis, Jonathan Hill, Ewa Cairns, and David A. Bell

Submissions from 2003

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Erratum: Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA (Journal of Immunology (2003) 171 (691-696)), Jonathan A. Hill, Thomas E. Ichim, Kornel P. Kusznieruk, Mu Li, Xuyan Huang, Xiaotao Yan, Robert Zhong, Ewa Cairns, David A. Bell, and Wei Ping Min

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Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA, Jonathan A. Hill, Thomas E. Ichim, Kornel P. Kusznieruk, Mu Li, Xuyan Huang, Xiaotao Yan, Robert Zhong, Ewa Cairns, David A. Bell, and Wei Ping Min

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Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule, Jonathan A. Hill, Scott Southwood, Alessandro Sette, Anthony M. Jevnikar, David A. Bell, and Ewa Cairns

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The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse model., Jonathan A. Hill, Dequn Wang, Anthony M. Jevnikar, Ewa Cairns, and David A. Bell

Submissions from 2002

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The influence of HLA-DR4 (0401) on the immune response to type II collagen and the development of collagen induced arthritis in mice, Dequn Wang, Jonathan A. Hill, Ewa Cairns, and David A. Bell

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Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice, Dequn Wang, Jonathan A. Hill, Anthony M. Jevnikar, Ewa Cairns, and David A. Bell

Submissions from 1997

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V region gene analysis of human IgM hybridoma monoclonal anti-Sm antibodies, M. Mahmoudi, J. Y. Edwards, D. A. Bell, and E. Cairns

Submissions from 1995

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Defective antigen-receptor-mediated regulation of immunoglobulin production in B cells from autoimmune strains of mice, Colin C. Anderson, Ewa Cairns, Ulrich H. Rudofsky, and Nicholas R.C. Sinclair

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Immunoglobulin gene sequence anlaysis of anti-cardiolipin and anti-cardiolipin idiotype (h3) human monoglonal antibodies, Arthur Hohmann, Ewa Cairns, Michael Brisco, David A. Bell, and Betty Diamond

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The role of the immunoglobulin heavy chain in human anti‐dna antibody binding specificity, Ahmoud Mahmoudi, Gregory A. Denomme, Jane Y. Edwards, David A. Bell, and Ewa Cairns

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The Importance of the Diversity Region YYGS Motif in Anti‐DNA Antibody Binding to DNA, MAHMOUD MAHMOUDI, DAVID A. BELL, and EWA CAIRNS

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Nonsynonymous mutations in an Fc-receptor structural gene in NZB mice, Dennis J. Sawchuk, Mahmoud Mahmoudi, Ewa Cairns, and Nicholas R.St C. Sinclair

Submissions from 1994

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Immunoglobulin V Sequences of Two Human Antiplatelet Monoclonal Autoantibodies Derived from B Cells of Normal Origin, Gregory A. Denomme, Mahmoud Mahmoudi, Ewa Cairns, and David A. Bell

Submissions from 1993

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Immunoglobulin V region heavy and light chain gene sequences of the lymphoblastoid cell line GM 4672, Gregory A. Denomme, Mahmoud Mahmoudi, Jane Y. Edwards, Hélène Massicotte, Ewa Cairns, and David A. Bell

Submissions from 1992

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An inter-laboratory idiotype assay validation study., E. Cairns, S. Andrejchyshyn, and J. Rauch

Submissions from 1990

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Comparative study of idiotypes on monoclonal antibodies derived from patients with lupus and leprosy and from normal individuals, C. G. Mackworth-Young, E. Cairns, J. Sabbaga, H. Massicotte, B. Diamond, and R. S. Schwartz

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A human anti-cardiolipin autoantibody is encoded by developmentally restricted heavy and light chain variable region genes, Katherine A. Siminovitch, Virginia Misener, Pak C. Kwong, Pei Ming Yang, Carl A. Laskin, Ewa Cairns, David Bell, Laurence A. Rubin, and Pojen P. Chen

Submissions from 1989

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Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses, E. Cairns, P. C. Kwong, V. Misener, P. Ip, D. A. Bell, and K. A. Siminovitch

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Expression in systemic lupus erythematosus of an idiotype common to DNA-binding and nonbinding monoclonal antibodies produced by normal human lymphoid cells, E. Cairns, H. Massicotte, and D. A. Bell

Submissions from 1987

Antinucleic acid autoantibody responses of normal human origin: antigen specificity and idiotypic characteristics compared to patients with systemic lupus erythematosus and patients with monoclonal IgM., D. A. Bell, E. Cairns, K. Cikalo, V. Ly, J. Block, and W. Pruzanski

Submissions from 1986

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Cytoskeletal binding of monoclonal anti‐dna antibodies derived from tonsillar lymphoid cells of a normal subject, EWA Cairns, Ronald Komar, and David A. Bell

Submissions from 1985

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The in vitro production of anti-DNA antibody by cultured peripheral blood of tonsillar lymphoid cells from normal donors and SLE patients, E. Cairns, J. St. Germain, and D. A. Bell

Submissions from 1984

A comparison of serologic reactivity among SLE patients with or without anti-Ro (SS-A) antibodies, D. A. Bell, R. Komar, W. B. Chodirker, J. Block, and E. Cairns

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Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell origin, E. Cairns, J. Block, and D. A. Bell

Submissions from 1983

Immunoregulation in rheumatoid arthritis: Evaluation of T lymphocyte function in the control of polyclonal immunoglobulin synthesis in vitro, N. Bellamy, E. Cairns, and D. A. Bell

Submissions from 1980

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Peanut and horse radish peroxidase isoenzymes. Intraspecies and interspecies immunological relatedness, EWA CAIRNS, ROBERT B.VAN HUYSTEE, and WILLIAM L. CAIRNS