Title

Quantitative tissue spectroscopy techniques for measuring cerebral perfusion and metabolism

Document Type

Conference Proceeding

Publication Date

1-1-2018

Journal

Optics InfoBase Conference Papers

URL with Digital Object Identifier

10.1364/BRAIN.2018.BF2C.4

Abstract

© OSA 2018. The brain constitutes 2% of the total body weight but accounts for 20% and 25% of total body basal oxygen and glucose consumption, respectively. As well, the brain has very limited energy storage; thus, it relies on adequate blood flow for oxygen and glucose delivery, and disruption in supply can has devastating effects on the brain. In this talk we'll present three pointof- care optical sensing techniques that can quantify cerebral perfusion and oxygen metabolism (i.e., cerebral metabolic rate of oxygen and oxygenation state of cytochrome c oxidase). We will describe the technologies (time-resolved spectroscopy, diffuse correlation spectroscopy, and hyperspectral continuous-wave near-infrared spectroscopy), the advanced algorithms we developed to analyze the optical data to convert them into physiological parameters, and some applications in animal models of brain injury and neonatal studies.

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