What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects?
Document Type
Letter to the Editor
Publication Date
6-1-2018
Journal
The European Respiratory Journal
Volume
51
Issue
6
First Page
1800324
URL with Digital Object Identifier
https://doi.org/10.1183/13993003.00324-2018
Abstract
Pulmonary magnetic resonance imaging (MRI) using inhaled polarised gases provides a way to directly visualise and sensitively measure lung ventilation abnormalities or ventilation defects [1]; the burden in individual patients may be directly quantified as the percent ventilation volume [2], ventilation defect volume (VDV) [3] or ventilation defect percent (VDP) [4], which is VDV normalised to the total lung volume. In patients with asthma, MRI ventilation defects worsen during methacholine [5] and exercise challenge [5, 6], and respond to bronchodilation [5, 6]. However, it is still unknown if quantitative changes in MRI ventilation abnormalities directly reflect changes in patient-related outcomes like symptoms; this is important when considering MRI for clinical and research studies in asthma patients, which require an understanding of the minimal clinically important difference (MCID).
Citation of this paper:
Eddy RL, Svenningsen S, McCormack DG, et al. What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects? Eur Respir J 2018; 51: 1800324 [https://doi.org/10.1183/13993003.00324-2018].
Notes
This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication. The final published version is available at: https://doi.org/10.1183/13993003.00324-2018