Faculty
Science
Supervisor Name
Dr. Alexei Ouriadov
Keywords
MRI, hyperpolarized gas MRI, emphysema, ventilatory ADC, apparent diffusion coefficient, ventilation defect percent
Description
Hyperpolarized gas pulmonary MRI provides the identification of biomarkers of various obstructive lung diseases such as emphysema. However, emphysema progression is able to cause increasing unventilated lung areas which likely excludes the estimates of the largest apparent diffusion coefficient (ADC). As such, longitudinal observation of the emphysema progression using hyperpolarized gas MRI-based ADC can be problematic, masking the severity of emphysema. The ventilatory ADC (vADC) method, which is the combination of static-ventilation (SV) and ADC measurements, adapted for 129Xe MRI should aid to provide an accurate assessment of the emphysema-progression. Moreover, the SV measurements providing the gas-distribution should remain to portray an increase in the ventilation defects reflecting the progression of emphysema. The objective of this project is to show that the progression of emphysema can be accurately quantified using the vADC approach by utilizing pulmonary static-ventilation and diffusion-weighted images of 129Xe.
Acknowledgements
Thank you to Dr. Alexei Ouriadov and Western University - Undergraduate Summer Research Internship for their continued support as well as guidance on this project.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Document Type
Poster
Included in
The Use of the 129Xe MRI Ventilatory ADC Approach for the Evaluation of Emphysema Progression
Hyperpolarized gas pulmonary MRI provides the identification of biomarkers of various obstructive lung diseases such as emphysema. However, emphysema progression is able to cause increasing unventilated lung areas which likely excludes the estimates of the largest apparent diffusion coefficient (ADC). As such, longitudinal observation of the emphysema progression using hyperpolarized gas MRI-based ADC can be problematic, masking the severity of emphysema. The ventilatory ADC (vADC) method, which is the combination of static-ventilation (SV) and ADC measurements, adapted for 129Xe MRI should aid to provide an accurate assessment of the emphysema-progression. Moreover, the SV measurements providing the gas-distribution should remain to portray an increase in the ventilation defects reflecting the progression of emphysema. The objective of this project is to show that the progression of emphysema can be accurately quantified using the vADC approach by utilizing pulmonary static-ventilation and diffusion-weighted images of 129Xe.