Faculty
Schulich Medicine & Dentistry
Supervisor Name
Dr. Mansour Haeryfar
Keywords
cross-talk, iNKT cell, MAIT cell, immunology, T cell, invariant T cells, cytokines, immune interactions, immune regulation
Description
Invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells are unique subsets of invariant T cells that are involved in regulating various tumor responses and display potent anti-microbial properties. Upon their activation, iNKT and MAIT cells secrete large quantities of T helper 1 (Th1)-, Th2-, and Th17-type cytokines that mediate their ability to regulate a variety of other immune cells, including B cells, natural killer cells, and macrophages. However, whether and how iNKT and MAIT cells regulate each other in vivo remains unknown. Here, we provide evidence for a cross-talk between iNKT and MAIT cells that resembles the interactions they have with other immune cells.
Acknowledgements
I would like to thank Dr. Mansour Haeryfar for his support and guidance with this project. I would also like to thank Md Rasheduzzaman Rashu and Dr. Marina Ninkov for their technical help and support. Lastly, I would like to thank the USRI program and Schulich Medicine & Dentistry for funding this exciting research.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Document Type
Poster
Included in
Interrogation of the iNKT-MAIT Cell Interface
Invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells are unique subsets of invariant T cells that are involved in regulating various tumor responses and display potent anti-microbial properties. Upon their activation, iNKT and MAIT cells secrete large quantities of T helper 1 (Th1)-, Th2-, and Th17-type cytokines that mediate their ability to regulate a variety of other immune cells, including B cells, natural killer cells, and macrophages. However, whether and how iNKT and MAIT cells regulate each other in vivo remains unknown. Here, we provide evidence for a cross-talk between iNKT and MAIT cells that resembles the interactions they have with other immune cells.