Faculty
Kinesiology
Supervisor Name
Dr. Jamie Melling
Keywords
Type 1 Diabetes, Male, Exercise, Hypoglycemia, Metabolism, Glycogen
Description
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder that results in insufficient endogenous insulin production. Regular exercise has numerous health benefits for individuals with T1DM, however, most insulin-dependent diabetics avoid physical activity due to the fear of exercise-induced hypoglycemia (low blood glucose/BG).
The risk of hypoglycemia in this population may be partly due to lower liver glycogen stores which is a major source of blood glucose during exercise. However, the mechanism that leads to lower glycogen stores in T1DM is unknown.
The purpose of this study was to determine the effect of an acute bout of moderate-intensity aerobic exercise on:
- Glycogen storage in the liver and skeletal muscle of T1DM rats.
- Content of gluconeogenic enzymes including Glucose 6-Phosphatase (G6Pase) and Phosphoenolpyruvate Carboxykinase (PEPCK) in T1DM rats.
Acknowledgements
I want to thank my supervisor, Dr. Jamie Melling for his valuable mentorship throughout the summer. I would also like to thank Mitch Sammut for his guidance in western blotting techniques and other lab protocols. Also, thank you to fellow USRI student, Julianna Mereu, for assisting me in various lab procedures. Finally, special thanks to Western Research, Western Libraries and Student Experience for making this incredible research opportunity possible.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Document Type
Poster
Included in
Exercise Science Commons, Medical Biochemistry Commons, Medical Molecular Biology Commons, Medical Physiology Commons, Nutritional and Metabolic Diseases Commons
The Effect of Type 1 Diabetes on the Metabolic Response to Exercise
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder that results in insufficient endogenous insulin production. Regular exercise has numerous health benefits for individuals with T1DM, however, most insulin-dependent diabetics avoid physical activity due to the fear of exercise-induced hypoglycemia (low blood glucose/BG).
The risk of hypoglycemia in this population may be partly due to lower liver glycogen stores which is a major source of blood glucose during exercise. However, the mechanism that leads to lower glycogen stores in T1DM is unknown.
The purpose of this study was to determine the effect of an acute bout of moderate-intensity aerobic exercise on:
- Glycogen storage in the liver and skeletal muscle of T1DM rats.
- Content of gluconeogenic enzymes including Glucose 6-Phosphatase (G6Pase) and Phosphoenolpyruvate Carboxykinase (PEPCK) in T1DM rats.