Physiology and Pharmacology Publications
Document Type
Article
Publication Date
5-19-2020
Journal
Cell Reports Medicine
Volume
1
Issue
2
First Page
100018
Last Page
100018
URL with Digital Object Identifier
https://doi.org/10.1016/j.xcrm.2020.100018
Abstract
Bariatric surgery, in addition to the benefit of sustained weight loss, can also reduce cardiometabolic risk and mortality. Lifelong vessel maintenance is integral to the prevention of cardiovascular disease. Using aldehyde dehydrogenase activity, an intracellular detoxifying enzyme present at high levels within pro-vascular progenitor cells, we observed an association between chronic obesity and "regenerative cell exhaustion" (RCE), a pathology whereby chronic assault on circulating regenerative cell types can result in adverse inflammation and diminished vessel repair. We also describe that, at 3 months following bariatric surgery, systemic inflammatory burden was reduced and pro-angiogenic macrophage precursor content was improved in subjects with severe obesity, suggesting the restoration of a microenvironment to support vessel homeostasis. These data suggest that bariatric surgery may reverse deleterious events that predispose patients with morbid obesity to cardiovascular risk.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Citation of this paper:
David A. Hess, Justin Z. Trac, Stephen A. Glazer, Daniella C. Terenzi, Adrian Quan, Hwee Teoh, Mohammed Al-Omran, Deepak L. Bhatt, C. David Mazer, Ori D. Rotstein, Subodh Verma, Vascular Risk Reduction in Obesity through Reduced Granulocyte Burden and Improved Angiogenic Monocyte Content following Bariatric Surgery, Cell Reports Medicine, Volume 1, Issue 2, 2020, 100018, ISSN 2666-3791, https://doi.org/10.1016/j.xcrm.2020.100018. (https://www.sciencedirect.com/science/article/pii/S2666379120300239)
