Gene Expression Microarray Data from Human Microvascular Endothelial Cells Supplemented with a Low Concentration of Niacin

Authors

Nica M. Borradaile, Western UniversityFollow
Jennifer M. Hughes-Large, Western UniversityFollow

Document Type

Article

Publication Date

2-3-2016

Journal

Data in Brief

Volume

6

First Page

899

Last Page

902

URL with Digital Object Identifier

http://dx.doi.org/10.1016/j.dib.2016.01.039

Abstract

The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly through activation of niacin receptors [1]. Here we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in human microvascular endothelial cells treated with 10 μM niacin. Statistical analyses of robust multi-array average (RMA) values revealed that only 16 genes exhibited greater than 1.3-fold differential expression. Of these 16, only 5 were identified protein coding genes, while 3 of the remaining 11 genes appeared to be small nuclear/nucleolar RNAs. Altered expression of EFCAB4B, NAP1L2, and OR13C8 was confirmed by real time quantitative PCR.