Physiology and Pharmacology Publications

Differential long-term depression in CA3 but not in dentate gyrus following low-frequency stimulation of the medial perforant path.

Document Type

Article

Publication Date

7-1-2011

Journal

Synapse (New York, N.Y.)

Volume

65

Issue

7

First Page

677

Last Page

686

Abstract

Synaptic plasticity may depend not only on the afferent fibers but also on the recipient structure. The medial perforant path (MPP) from the entorhinalcortex projects to both the dentate gyrus (DG) and CA3, resulting in excitatory postsynaptic potentials (EPSPs) in both areas. In this study, we showed that long-term depression (LTD) following low-frequency stimulation of MPP was found only in CA3a, a CA3 subfield, but not in DG. Field potentials were recorded and current source density (CSD) analyzed in CA3a and DG following stimulation of MPP in urethane-anesthetized rats. MPP evoked a short-latency population spike (PS) and EPSP in CA3a,

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