Physiology and Pharmacology Publications

Title

A normalization circuit underlying coding of spatial attention in primate lateral prefrontal cortex

Document Type

Article

Publication Date

3-1-2019

Journal

eNeuro

Volume

6

Issue

2

URL with Digital Object Identifier

10.1523/ENEURO.0301-18.2019

Abstract

© 2019 Duong et al. Lateral prefrontal cortex (LPFC) neurons signal the allocation of voluntary attention; however, the neural computations underlying this function remain unknown. To investigate this, we recorded from neuronal ensembles in the LPFC of two Macaca fascicularis performing a visuospatial attention task. LPFC neural responses to a single stimulus were normalized when additional stimuli/distracters appeared across the visual field and were wellcharacterized by an averaging computation. Deploying attention toward an individual stimulus surrounded by distracters shifted neural activity from an averaging regime toward a regime similar to that when the attended stimulus was presented in isolation (winner-take-all; WTA). However, attentional modulation is both qualitatively and quantitatively dependent on a neuron’s visuospatial tuning. Our results show that during attentive vision, LPFC neuronal ensemble activity can be robustly read out by downstream areas to generate motor commands, and/or fed back into sensory areas to filter out distracter signals in favor of target signals.

This document is currently not available here.

Share

COinS