Cholesterol and cartilage do not mix well

Authors

Frank Beier, Western University

Document Type

Article

Publication Date

5-1-2019

Journal

Nature Reviews Rheumatology

First Page

253

Last Page

254

URL with Digital Object Identifier

10.1038/s41584-019-0204-z

Abstract

© 2019, Springer Nature Limited. The molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA?