Cholesterol and cartilage do not mix well
Nature Reviews Rheumatology
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© 2019, Springer Nature Limited. The molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA?