Physiology and Pharmacology Theses and Dissertations

 

This collection contains theses and dissertations from the Department of Physiology and Pharmacology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Follow

Theses/Dissertations from 2024

PDF

The Effects of S-glutathionylation on the Structure and Function of the Mitochondrial Calcium Uniporter (MCU), Arine Pawakian

Theses/Dissertations from 2023

PDF

Characterization of A Novel Mouse Model Expressing Human 82-kDa Choline Acetyltransferase: Potential Role in Physiological and Pathological Aging, Hadir EmadElDin AlQot

PDF

Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis, Jasika Bashal

PDF

Lipoprotein(a), Oxidized Phospholipids, and Vascular Smooth Muscle Cell Phenotype and Viability, Michael Dunphy

PDF

Upstream Regulators and Downstream Signals of YAP/TAZ in NAFLD, Chen Jun Gao

PDF

Regulation of Metalloproteinase Activity is Critical for Pulmonary Microvascular Endothelial Cell Barrier Function, Devika P. Jayawardena

PDF

Generation Of An Amplifiable Biosensor Based On Conjugation For Detection Of Salmonella In Food Samples, Kyra Keer

PDF

Characterizing the Spatial Distribution of Inhibitory Interneurons Across Early Sensory and Association Areas in Callithrix jacchus, Nika Khajehdehi

PDF

Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics, Yong Jin Lim

PDF

Adverse Effects and Pharmacokinetic Characteristics of High-Dose Glucocorticoid Treatment in Children with Rheumatic Diseases, Renee X. Pang

PDF

Metabolomic Biomarkers for Hypertensive Disease of Pregnancy, Akasham Rajagopaul

PDF

Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc, Taylor Dominick Spence Shelton

PDF

Non-Renal Alterations of Drug Disposition in Chronic Kidney Disease, Nicholas Tonial

PDF

Eukaryotic Elongation Factor 1A1 in Non-Alcoholic Fatty Liver Disease and Metabolism, Rachel B. Wilson

PDF

Characterizing How beta-annulated 1,4-Dihydropyridines Inhibit TGF-beta Signalling, Stephanie Wojtowicz-Piotrowski

PDF

Effects of High Glucose on Autophagy and Apoptosis in Preimplantation Mouse Embryo Culture, Virginia Wolfe

PDF

Functional Validation of Human Multipotent Stromal Cell-secreted Islet Regenerative Proteins, Xin Yue Xie

Theses/Dissertations from 2022

PDF

Collagen IV-β1Integrin Regulation of Exocytotic Machinery in Pancreatic Beta-Cell Insulin Secretion, Malina Barillaro

PDF

Biomechanical Loading as a Driver of Synovial Neovascularization and Microvascular Dysfunction in Knee Osteoarthritis, Mckenzie Carter

PDF

Impaired Efferocytosis in Knee Osteoarthritis, Luigi M. Del Sordo

PDF

The Impact of Excess Nutrients, Fatty Acids or Glucose, on BeWo Placental Trophoblast Metabolic Function, Zachary JW Easton

PDF

MicroRNAs as Non-invasive Predictors of Preimplantation Embryo Developmental Competence, David C. Hawke

PDF

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 are Important for their Gap Junction Channel Ion Permeation and Gating, Roa'a Jaradat

PDF

Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum, Gurneet Jassal

PDF

The Effect of OATP2B1-Mediated Statin Transport on Beta Cell Dysfunction, Jihoon Kwon

PDF

The Arg76 Residue of Cx50, Cx43 and Cx45 is Important for the Formation of Functional Gap Junction Channels, Tianhe Li

PDF

The Molecular Mechanisms of Hepatic Mitochondrial Dysfunction in Growth-Restricted Offspring with Hyperlipidemia, Shelby L. Oke

PDF

Tracing the Fate of Cytokeratin 19+ Cells During Beta Cell Regeneration Stimulated by Multipotent Stromal Cell-Secreted Effectors, Nazihah Rasiwala

PDF

Exploring the effects of spinal cord stimulation for freezing of gait in parkinsonian patients, Olivia Samotus

PDF

The Effects Of Autophagy And Proteasomes On TGFβ Signalling And EMT, Charles Brandon Trelford

PDF

Roles of STIM1 Cys56 and Cys49 in Store-Operated Ca2+ Entry and Cardiac Rhythm during Myocardial Ischemia and Reperfusion, Kaiyuan Wang

PDF

Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma, Xiaoyi Wang

Theses/Dissertations from 2021

PDF

Exogenous Surfactant as a Delivery Vehicle for Intrapulmonary Therapeutics, Brandon J. Baer

PDF

Maternal Lifelong Western Diet Consumption Impacts Placental and Brain Development in the Term Guinea Pig Fetus, Carlene H. Cihosky

PDF

Characterization and modulatory influence of pyruvate kinase muscle isoforms 1 and 2 within the murine pluripotent continuum, Joshua G. Dierolf

PDF

Fatty Acid Regulation of the Nrf2/Keap1 Pathway During Mouse Preimplantation Embryo Development, Grace Dionne

PDF

Inwardly Rectifying Potassium Channels: Regulators of Myogenic Tone in Cerebrovascular Smooth Muscle, Jacob Fletcher

PDF

Investigating the role of interleukin-15 in post-traumatic osteoarthritis, Ermina Hadzic

PDF

Modulation of GABAA Receptor by Neurosteroids and Protein Kinases in Health and Disease, Jaymin Jeong

PDF

Effects of ergothioneine on endothelial cell and macrophage characteristics, and markers of atherosclerosis risk under high lipid conditions, Daniel Lam-Sidun

PDF

Free fatty acid treatment alters autophagy during mouse preimplantation embryo development, Zuleika C. L. Leung

PDF

Creating Tools to Study the Signaling and Function of the Adhesion Family of GPCRs, Victor M. Mirka

PDF

The effects of decellularized adipose tissue constructs on mesenchymal stromal/stem cell phenotype and pro-angiogenic secretory function., Yehia Moharrem

PDF

Uncovering the Structural Basis for Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit (MCUb) Function, Megan L. Noble

PDF

Targeting CCN Proteins in the Treatment of Dermal Fibrosis, Alex Peidl

PDF

Characterizing the structural, biophysical and functional effects of S-Glutathionylation on STIM1 Ca2+ sensing, Christian Michael Sirko

PDF

Effects of Annexin A5 on Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Extracellular Vesicles, Brent Jeffrey Tschirhart

PDF

Impact of Clinical and Pharmacogenetic Variables on the Risk of Fluoropyrimidine-Related Adverse Events within Ontario, Theodore J. Wigle

PDF

Characterizing the Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Skeletal Muscle Mitochondrial Function and Myogenesis During Oxidative Stress and IUGR., Allyson J. Wood

Theses/Dissertations from 2020

PDF

Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration, Brianna Ananthan

PDF

Investigating pathways associated with intervertebral disc degeneration and back pain., Geoffrey J. Kerr

PDF

The Role of Histone Demethylases in Learning and Memory in the Mushroom Body of Drosophila melanogaster, Crystal Keung

PDF

Characterization of Mechanotransduction in Annulus Fibrosus Cells, Min Kyu M. Kim

PDF

The Role of TIMP3 in Microvascular Endothelial Cell-Extracellular Matrix Interaction and Regulation of Microvascular Barrier Function, Nidhi Kulkarni

PDF

The Role of Synovium and Synovial Macrophages in Experimental Post-Traumatic Knee Osteoarthritis, Yue Lai-Zhao

PDF

The Role of Regulator of G Protein Signaling 2 in Inflammatory Cytokine Release in Endotoxemia in Mice, Xin Tong Ma

PDF

Mushroom body-specific gene regulation by the SWI/SNF chromatin remodeling complex, Kevin CJ Nixon

PDF

The Effects of Maternal Delta-9-Tetrahydrocannabinol and Cannabidiol Exposure on Fetal Heart Development in Mice, Gregory Robinson

PDF

Mitogen Inducible Gene-6 in Joint Health and Osteoarthritis, Melina Rodrigues Bellini

PDF

Human Genetic Variation in Na+-Taurocholate Co-transporting Polypeptide (NTCP; SLC10A1) and Targeted Slc10a1 Disruption in Mice: Effects on Bile Acid and Rosuvastatin Transport, Laura E. Russell

PDF

Pan-Cancer Analysis of Telomerase Reverse Transcriptase (TERT) Isoforms, Mathushan Subasri

PDF

Mechanisms of beta-cell deficiency in gestational diabetes and strategies to reverse hyperglycemia, Sandra K. Szlapinski

PDF

Molecular Mechanisms Regulating the Platelet Thrombin Receptor PAR4, Pierre E. Thibeault

PDF

Regulators of Ectopic Calcification in a Mouse Model of DISH: A Multi-Omics Perspective, Matthew A. Veras

PDF

The amino terminal domains of sheep Cx46 or Cx50 determine their gap junction channel open stability and unitary channel conductance, Benny Yue

Theses/Dissertations from 2019

PDF

Absence of Activating Transcription Factor 3 Reduces Severity of Recurrent Pancreatitis and K-RAS Mediated PDAC in Mice, Nawab Azizi

PDF

HEI-OC1 Cochlear Cells as an In Vitro Model to Study the Role of Connexins in Ototoxicity and Hearing Loss, Rianne Beach

PDF

Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain, Matthew J. Borrelli

PDF

The Role of Pannexin 1 during Human Adipogenesis in vitro, Jamie Emily Ching

PDF

Apolipoprotein(a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein, Justin Clark

PDF

Identification of Human Postnatal Progenitor Cells with Multifaceted Regenerative Functions, Tyler T. Cooper

PDF

Integrin-linked Kinase Modulation of Melanocytic Lineage Cells, Melissa Crawford

PDF

Pregestational Diabetes Induced Congenital Heart Defects and Coronary Artery Malformations; Mechanisms and Preventative Therapies, Anish Engineer

PDF

The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels, Melissa Fenech

PDF

Maternal nicotine exposure induces congenital heart defects in the offspring of mice, Elizabeth Greco

PDF

Synthesis and Characterization of American Ginseng Polysaccharides Nanoparticles, Vincent Lee

PDF

Applications of Hair as a Record of Systemic Exposure to Cortisol, Jeffrey Matthew Levine

PDF

Dynamic mechanostimulation of live cells during real-time microscopy, Daniel Lorusso

PDF

Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry, Matthew Novello

PDF

Effects of Niacin and Vitamin D on Endothelial Cell Angiogenic Function and Vascular Regeneration During Lipotoxicity, Kia Mae Peters

PDF

The role of ATF4 in amyloid-beta-induced neuronal death., Gillian Petroff

PDF

YAP-mediated mechanotransduction promotes fibrotic activity, Michael Racanelli

PDF

The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis, Stephen E. Sherman

PDF

Mapping and functional characterization of proteolytic cleavage of murine kidney injury molecule-1, Saranga Sriranganathan

PDF

Phenotypic and Metabolic Plasticity In Canine Cellular Reprogramming, Ian C. Tobias

PDF

Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development, Maisoon Dafalla Yousif

Theses/Dissertations from 2018

PDF

The Role Of FER Kinase In Human Melanoma Growth and Invasion, Shinthujah Arulanantham

PDF

The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva, Akina Au

PDF

Clinical and Genetic Predictors of Aromatase Inhibitor-Induced Arthralgia, Adrienne Elizabeth Borrie

PDF

The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules, Steve Chung

PDF

The Role of Hand1 in the Development of the Lateral Plate Mesoderm in Xenopus, Victoria A. Deveau

PDF

A normalization circuit of attention in primate lateral prefrontal cortex, Lyndon Duong

PDF

The Role of p66Shc in Mouse Blastocyst Development, Nicole A. Edwards

PDF

Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy, Cheng Jay Fang

PDF

Clinical And Pharmacogenetic Determinants Of Plasma Factor Xa Inhibitor Systemic Exposure, Markus Gulilat

PDF

Role Of The Dorsal Striatum In Learning and Decision Making, Nole M. Hiebert

PDF

Investigating the Practical and Clinical Effectiveness of Applying Current Steering to Deep Brain Stimulation for Parkinsonian Gait Therapy, Daphne Hui

PDF

The use of current steering during subthalamic deep brain stimulation to alleviate upper limb symptoms of Parkinson's disease, Shabna Iftikar Mohideen

PDF

Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood, Reza Khazaee

PDF

Modulation of parathyroid hormone 1 receptor signaling by extracellular nucleotides, Brandon Kim