Physiology Theses and Dissertations
This collection contains theses and dissertations from the Department of Physiology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2020
Investigating the Role of Nuclear Receptor Peroxisome Proliferator-Activated Receptor δ in Obesity-Associated Osteoarthritis, Bethia C. To
Theses/Dissertations from 2017
CCN Proteins in Metastatic Melanoma, James Hutchenreuther
Regulation of Human 69-kDa Choline Acetyltransferase Protein Stability and Function by Molecular Chaperones and the Ubiquitin-Proteasome System, Trevor M. Morey
Exercise Protects Against Congenital Heart Defects Induced by Pregestational Diabetes, Tana Saiyin
Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia, Jelena Toma
Theses/Dissertations from 2016
Peroxisome Proliferator Activated Receptor Delta in Osteoarthritis, Anusha Ratneswaran
Theses/Dissertations from 2015
Prenatal Exposure to Bisphenol A Disrupts Fetal Liver Maturation in a Sex-Specific Manner, Bianca DeBenedictis
Mechanisms of neural precursor cell apoptosis by microglia-derived cytokines, Jennifer Guadagno
Surfactant and Matrix Metalloproteinase 3 in the Pathogenesis of Acute Lung Injury, Valeria Puntorieri
Theses/Dissertations from 2014
Pathway-Specific Signaling and its Impact on Fertility: A Focus on the Kisspeptin Receptor, Kiss1r, Maryse R. Ahow
Roles of P2X7 Receptors in Adipose and Skeletal Tissues of Mice, Kim L. Beaucage
Regulation of CRFR1 and 5-HT2AR by PDZ Domain-Containing Proteins SAP97 and PSD-95, Henry A. Dunn
KISS1R Signaling Promotes Breast Cancer Metastasis, Cameron G-F Goertzen
Functional role of the striatum in stimulus-response learning: Evidence from functional MRI and patients with Parkinson's disease, Nole M. Hiebert
ILK modulates stress-induced apoptosis in epidermal keratinocytes, Michelle Im
A RHOG/ILK/ELMO2/RAC1 Pathways Modulates Microtubule Stability, Bradley C. Jackson
TAK1 Mediates TGF beta-1 Responses in Gingival Fibroblasts, Hanna Kuk
Mouse Models of Intervertebral Disc Development, Degeneration and Mechanical Loading, Matthew R. McCann
Pregestational Diabetes and Congenital Heart Defects: Role of Reactive Oxygen Species, Hoda Moazzen
Niacin and microvascular endothelial cell response to fatty acid excess and hypoxia, Dominic Pang
Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro, Alexei Popell
Characterization of Blood-Derived Human Progenitor Cells for Vascular Regeneration, David Putman
Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα, Fitore Raka
The Implications of Altered Cholinergic Signaling in Cardiac Health and Disease, Ashbeel Roy
Islet Regenerative Properties of Ex Vivo Expanded Hematopoietic Progenitor Cells, Ayesh K. Seneviratne
NGN3 Expression in Definitive Endoderm Progenitors Specifies Pancreatic Endocrine Precursors, Ahmed Shah
Mutations at the 46th residue change properties of Cx50 gap junction channels, Xiaoling Tong
Characterization of Human 82-kDa Choline Acetyltransferase expression in a newly developed Transgenic Mouse Model, Silke M. Vanvaerenbergh
Amyloid β Peptides, Signalling and Trafficking of the α7 Nicotine Receptor, Kirk Young
Theses/Dissertations from 2013
The role of choline acetyltransferase variants in Alzheimer's disease models, Shawn Albers
Traumatic Injury in vitro Elicits JNK-mediated Human Astrocyte Retraction, but Spares Cerebrovascular Endothelial Cells, Claudia Augustine
Skin Diseases and Non-Syndromic Hearing Loss Linked to Cx30 Mutations Arise Through Several Distinct Mechanisms, Amy C. Berger
Transforming growth factor-beta receptor signalling is modulated by integrin-linked kinase, Stellar H. Boo
Contribution of TRPM2 to Memory Loss in an Alzheimer's Mouse Model, Megan M. Chen
Characterizing Stomatin-like Protein 2 and its Role in Neuron Survival, Lisa A. Foris
Atrial Fibrillation-Linked Germline GJA5/Connexin40 Mutants Showed an Increased Hemichannel Function, Matthew D. Hills
Effects of niacin in human vascular endothelial cells during lipotoxicity, Jennifer M. Hughes-Large
Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia, Waseem Iqbal
Regulation of TRPM2 channels by Fyn kinase, Matthew L. Johnston
A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function, Liz A. Merwin
Intermittent Hypoxia Affects Leptin and Leptin Receptor Signaling in the Rat Carotid Body, Scott A. Messenger
Intermittent Hypoxia Alters Metabolic and Cardiovascular Neural Pathways, Jason Michael Moreau
Aging and Obesity Models in Osteoarthritis, Sara Ohora
Cholesterol-Mediated Dysfunction of Surfactant Effects of Surfactant Protein-A and Diet-Induced Hypercholesterolemia, Joshua Qua Hiansen
Molecular Mechanisms Underlying the Early Life Programming of the Liver, Gurjeev Sohi
Elongation factor 1A-1 and hepatocyte response to fatty acid excess, Alexandra M. Stoianov
The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis, (Peter) Thin X. Vo
Ectopic Mineralization of Spinal Tissues in Mice Lacking Equilibrative Nucleoside Transporter 1, Sumeeta Warraich
The Role of α5GABA(A) Receptors in Brain Inflammation, Jason K. Wong
Improving Cardiac Repair by Stem Cell Factor Post-Myocardial Infarction, Fuli Xiang
Theses/Dissertations from 2012
Ginseng Extract Treatment Influences on Preimplantation Development in Vitro, and Pregnancy and Post-Partum Development in the Mouse, Danyka D. Belanger
The Developmental and Adaptive role of Mitogen Activated Protein Kinase Pathways During Preimplantation Development, Christine E. Bell
Human Cerebrovascular Endothelial Cell Responses in Severe Sepsis, Christopher J. Blom
Involvement of Interleukin-33/ST2 in Myocardial Dysfunction in Murine Model of Sepsis, Yoonmi Choe
KISS1R Induces Human Mammary Epithelial Cell Invasiveness and Promotes Breast Cancer Cell Migration and Invasion via IQGAP1, Donna Cvetkovic
Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction, Jessica L. Esseltine
Uncovering Dual Roles for PERK Signaling During Experimentally Induced Pancreatitis, Elena Fazio
The Role of Glycogen Synthase Kinase 3 Beta in Skeletal Development, J. Ryan Gillespie
The Effects of Telomerase Inhibition on Cellular Senescence in Fetal Guinea Pig Muscle Cells, Stephanie E. Hallows
Functional Significance of ILK-ELMO2 Interactions in Epidermal Keratinocytes, Ernest Ho
DNA Damage and Oxidative Stress Induced-p53 Activity In Astrocytes causes Growth Arrest, Sarah A. Humphrey
The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling, Stephanie C. Kulhawy
Transforming Growth Factor Beta Receptor Partitioning: Molecular Mechanisms and Functional Consequences, Sarah E.A. McLean
Chronic North American Ginseng Administration Alters Metabolic and Cardiovascular Variables in the Rat, Megan J. Migchels
Placental insufficiency resulting in fetal growth restriction alters synaptic development and neuronal myelination in guinea pigs at term, Karolina Piorkowska
The Role of Transforming Growth Factor Alpha in Osteoarthritis and Skeletal Development, Shirine E. Usmani
Roles of PGC-1α/PPARs pathway in regulating insulin sensitivity in mouse skeletal muscle cells under prolonged hypoxia, Yunyan Zhang
Theses/Dissertations from 2011
The Effects of Low Protein during Gestation on Mouse Pancreas Development and Beta Cell Regeneration, Aaron R. Cox
Morpho-physiological analysis of interneuronal populations in the rat piriform cortex before and after kindling induced epilepsy, Cezar Gavrilovici
The Vascular Link Between Intrauterine Hypoxia and Postnatal Cardiovascular Pathology, Jennifer A. Thompson
Mechanisms of Atrial Arrhythmia: Investigations of the Neuro-Myogenic Interface in the Mouse, Jari Michael Tuomi
Role of Rac1 in myocardial TNF-alpha expression in sepsis, Ting Zhang
Theses/Dissertations from 2010
The roles of nitric oxide synthases (NOS) in endochondral bone formation, Qian Yan
Cardiac Adaptation To Chronic Blockade Of Voltage-Gated, L-Type Calcium Channels In The Sarcolemma, Ji Zhou