Hemolytic anemia following intravenous immunoglobulin therapy in patients treated for Kawasaki disease: A report of 4 cases

Authors

Roberta Berard, London Health Sciences CentreFollow
Blair Whittemore, Centre Universitaire de Santé McGill, Hôpital de Montreal Pour Enfants
Rosie Scuccimarri, Centre Universitaire de Santé McGill, Hôpital de Montreal Pour Enfants

Document Type

Article

Publication Date

4-16-2012

Journal

Pediatric Rheumatology

Volume

10

URL with Digital Object Identifier

10.1186/1546-0096-10-10

Abstract

Background: Hemolytic anemia is a rare but reported side effect of intravenous immunoglobulin (IVIG) therapy. The risk of significant hemolysis appears greater in those patients who receive high dose IVIG. The etiology is multifactorial but may relate to the quantity of blood group antibodies administered via the IVIG product.Findings: We describe 4 patients with significant hemolytic anemia following treatment with IVIG for Kawasaki disease (KD). Direct antibody mediated attack as one of the mechanisms for hemolysis, in this population, is supported by the demonstration of specific blood group antibodies in addition to a positive direct antiglobulin test in our patients.Conclusions: Clinicians should be aware of this complication and hemoglobin should be closely monitored following high dose IVIG therapy. © 2012 Berard et al; licensee BioMed Central Ltd.