Paediatrics Publications
Document Type
Article
Publication Date
7-1-2019
Journal
Canadian Journal of Neurological Sciences
Volume
46
Issue
4
First Page
459
Last Page
463
URL with Digital Object Identifier
10.1017/cjn.2019.35
Abstract
We report three brothers born to consanguineous parents of Syrian descent, with a homozygous novel c.324G>A (p.W108) mutation in PTRH2 that encodes peptidyl-tRNA hydrolase 2, causing infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD). We describe the core clinical features of postnatal microcephaly, motor and language delay with regression, ataxia, and hearing loss. Additional features include epileptic seizures, pancreatic insufficiency, and peripheral neuropathy. Clinical phenotyping enabled a targeted approach to the investigation and identification of a novel homozygous nonsense mutation in PTRH2, c.324G>A (p.W108). We compare our patients with those recently described and review the current literature for IMNEPD.