Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.

Authors

Farid H Mahmud
Antoine B M Clarke
Kariym C Joachim
Esther Assor
Charlotte McDonald
Fred Saibil
Heather A Lochnan
Zubin Punthakee
Amish Parikh
Andrew Advani
Baiju R Shah
Bruce A Perkins
Caroline S Zuijdwijk
David R Mack
Dror Koltin
Emilia N De Melo
Eugene Hsieh
Geetha Mukerji
Jeremy Gilbert
Kevin Bax, Pediatric Gastroenterology, Department of Pediatrics, Children’s Hospital, London Health Sciences Centre, Western University, London, Ontario, CanadaFollow
Margaret L Lawson
Maria Cino
Melanie D Beaton
Navaaz A Saloojee
Olivia Lou
Patricia H Gallego
Premysl Bercik
Robyn L Houlden
Ronnie Aronson
Susan E Kirsch
William G Paterson
Margaret A Marcon

Document Type

Article

Publication Date

7-1-2020

Journal

Diabetes care

Volume

43

Issue

7

First Page

1553

Last Page

1556

URL with Digital Object Identifier

https://doi.org/10.2337/dc19-1944

Abstract

OBJECTIVE: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.

RESEARCH DESIGN AND METHODS: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA

RESULTS: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%,

CONCLUSIONS: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.

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