In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models

Authors

Julián Ernesto Nicolás Gulin
Mackenzie Anne Eagleson
Rodrigo A López-Muñoz
María Elisa Solana
Jaime Altcheh
Facundo Garcia-Bournissen MD PhDFollow

Document Type

Article

Publication Date

11-1-2020

Journal

Acta Tropica

Volume

211

First Page

105606

URL with Digital Object Identifier

https://doi.org/10.1016/j.actatropica.2020.105606

Abstract

Combination therapy has been proposed as an ideal strategy to reduce drug toxicity and improve treatment efficacy in Chagas disease. Previously, we demonstrated potent in vivo anti-Trypanosoma cruzi activity of voriconazole. In this work, we aimed to study the synergistic effect of voriconazole (VCZ) and benznidazole (BZ) both in vitro and in vivo models of T. cruzi infection using the Tulahuen strain. Combining VCZ and BZ at fixed concentrations, the inhibitory concentration 50% (IC