Paediatrics Publications

Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants

Document Type

Article

Publication Date

2-2017

Journal

Journal of Human Lactation

Volume

33

Issue

1

First Page

181

Last Page

187

URL with Digital Object Identifier

https://doi.org/10.1177/0890334416680176

Abstract

BACKGROUND: Mothers of preterm infants often are at risk of expressing an inadequate amount of milk for their infants and the use of galactogogues is often considered. Domperidone is a widely used galactogogue with little information available to guide clinicians regarding initiation, timing, and duration of treatment. Research aim: The primary objective of this study was to determine whether administration of domperidone within the first 21 days after delivery would lead to a higher proportion of mothers achieving a 50% increase in the volume of milk at the end of 14 days of treatment compared with mothers receiving placebo.

METHODS: Eligible mothers were randomized to one of two treatment arms: Group A-domperidone 10 mg orally three times daily for 28 days; or Group B-placebo 10 mg orally three times daily for 14 days followed by domperidone 10 mg orally three times daily for 14 days.

RESULTS: A total of 90 mothers of infants ≤ 29 weeks gestation were randomized. Mean milk volumes at entry were similar for both groups. More mothers achieved a 50% increase in milk volume after 14 days in Group A (77.8%) compared with Group B (57.8%), odds ratio = 2.56, 95% confidence interval [1.02, 6.25], p = .04.

CONCLUSION: A greater number of mothers experienced a 50% or more increase in human milk volume, but the absolute increase in milk volume was modest.

Notes

Collaborators: Fusch C, Kovacs L, Janvier A, Cauoette G, Lodha A, Bulleid B, McMillan D, Singh B.

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