Paediatrics Publications
Document Type
Article
Publication Date
1-2-2019
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume
39
Issue
1
First Page
177
Last Page
192
URL with Digital Object Identifier
https://doi.org/10.1523/JNEUROSCI.3496-17.2018
Abstract
The CCCTC-binding factor (CTCF) is a central regulator of chromatin topology recently linked to neurodevelopmental disorders such as intellectual disability, autism, and schizophrenia. The aim of this study was to identify novel roles of CTCF in the developing mouse brain. We provide evidence that CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE). Conditional
Notes
Also available open access in The Journal of Neuroscience V.39, NO 1 at https://doi.org/10.1523/JNEUROSCI.3496-17.2018