CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

Authors

Adrienne Elbert, Childrens Health Research Network
Daniel Vogt
Ashley Watson, Childrens Health Research Network
Michael Levy, Western University
Yan Jiang, Western University
Emilie Brûlé, Western University
Megan E Rowland, Western University
John Rubenstein
Nathalie G Bérubé, Western University

Document Type

Article

Publication Date

1-2-2019

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Volume

39

Issue

1

First Page

177

Last Page

192

URL with Digital Object Identifier

https://doi.org/10.1523/JNEUROSCI.3496-17.2018

Abstract

The CCCTC-binding factor (CTCF) is a central regulator of chromatin topology recently linked to neurodevelopmental disorders such as intellectual disability, autism, and schizophrenia. The aim of this study was to identify novel roles of CTCF in the developing mouse brain. We provide evidence that CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE). Conditional

Notes

Also available open access in The Journal of Neuroscience V.39, NO 1 at https://doi.org/10.1523/JNEUROSCI.3496-17.2018