Paediatrics Publications
Document Type
Article
Publication Date
1-1-2012
Journal
Journal of Pregnancy
Volume
2012
First Page
638476
Last Page
638476
URL with Digital Object Identifier
https://doi.org/10.1155/2012/638476
Abstract
Placental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beginning to be elucidated, and premature aging or cellular senescence through increased oxidative stress and DNA damage to telomeric ends may be initiators of these disease processes. This paper will explore the areas where telomere and telomerase biology can have significant effects on various tissues in the body in IUGR outcomes.
