CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-kB Complexes

Authors

Seung J. Kim, London Regional Cancer ProgramFollow
Samuel Asfaha, London Regional Cancer ProgramFollow
Frederick A. Dick, London Regional Cancer ProgramFollow

Document Type

Article

Publication Date

1-3-2019

Journal

Molecular Cell

Volume

73

Issue

1

First Page

1

Last Page

2

URL with Digital Object Identifier

https://doi.org/10.1016/j.molcel.2018.12.012

Abstract

PD-L1 plays a central role in immune recognition of cancer cells. In this issue of Molecular Cell, Jin et al. (2019) report that a phosphorylated retinoblastoma protein contacts the DNA-binding domain of p65 NF-kB, thereby blocking transcription of PD-L1.