Paediatrics Publications
Title
Β-cell receptor tyrosine kinases in controlling insulin secretion and exocytotic machinery: C-kit and insulin receptor
Document Type
Article
Publication Date
1-1-2018
Journal
Endocrinology
Volume
159
Issue
11
First Page
3813
Last Page
3821
URL with Digital Object Identifier
10.1210/en.2018-00716
Abstract
Insulin secretion from pancreatic β-cells is initiated through channel-mediated depolarization, cytoskeletal remodeling, and vesicle tethering at the cell membrane, all of which can be regulated through cell surface receptors. Receptor tyrosine kinases (RTKs) promote β-cell development and postnatal signaling to improve β-cell mass and function, yet their activation has also been shown to initiate exocytotic events in b-cells. This review examines the role of RTK signaling in insulin secretion, with a focus on RTKs c-Kit and insulin receptor (IR). Pathways that control insulin release and the potential interplay between c-Kit and IR signaling are discussed, along with clinical implications of RTK therapy on insulin secretion.