Paediatrics Publications
Document Type
Article
Publication Date
4-1-2012
Journal
Placenta
Volume
33
Issue
4
First Page
233
Last Page
243
URL with Digital Object Identifier
10.1016/j.placenta.2011.11.026
Abstract
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the hemochorial placenta. The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research. © 2012 Elsevier Ltd. All rights reserved.
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