Paediatrics Publications

Document Type

Article

Publication Date

4-1-2012

Journal

Placenta

Volume

33

Issue

4

First Page

233

Last Page

243

URL with Digital Object Identifier

10.1016/j.placenta.2011.11.026

Abstract

The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the hemochorial placenta. The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research. © 2012 Elsevier Ltd. All rights reserved.

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