Title

Traumatic brain injury: classification, models, and markers.

Authors

Dema Najem
Kerry Rennie
Maria Ribecco-Lutkiewicz
Dao Ly
Julie Haukenfrers
Qing Liu
Munyao Nzau
Douglas D Fraser, Western UniversityFollow
Mahmud Bani-Yaghoub

Document Type

Article

Publication Date

8-1-2018

Journal

Biochemistry and Cell Biology / Biochimie et Biologie Cellulaire

Volume

96

Issue

4

First Page

391

Last Page

406

URL with Digital Object Identifier

https://doi.org/10.1139/bcb-2016-0160

Abstract

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to its high incidence rate and often long-term sequelae, TBI contributes significantly to increasing costs of health care expenditures annually. Unfortunately, advances in the field have been stifled by patient and injury heterogeneity that pose a major challenge in TBI prevention, diagnosis, and treatment. In this review, we briefly discuss the causes of TBI, followed by its prevalence, classification, and pathophysiology. The current imaging detection methods and animal models used to study brain injury are examined. We discuss the potential use of molecular markers in detecting and monitoring the progression of TBI, with particular emphasis on microRNAs as a novel class of molecular modulators of injury and its repair in the neural tissue.

Notes

Article available at Biochemistry and Cell Biology / Biochimie et Biologie Cellulaire

https://doi.org/10.1139/bcb-2016-0160

© 2018 Her Majesty the Queen in right of Canada