Paediatrics Publications
Document Type
Article
Publication Date
8-16-2013
Journal
Journal of Biological Chemistry
Volume
288
Issue
33
First Page
23807
Last Page
23813
URL with Digital Object Identifier
10.1074/jbc.M112.436279
Abstract
Background: TrkA is a transmembrane receptor tyrosine kinase for nerve growth factor. Results: TrkA forms a molecular complex with insulin receptor and IRS-1 to induce Akt and Erk5 phosphorylation. Conclusion: The NGF-TrkA receptor influences insulin signaling. Significance: The TrkA receptor is involved in insulin signaling, and NGF may regulate neuronal glucose uptake as neurons are insulin-insensitive. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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