Paediatrics Publications

Document Type

Article

Publication Date

8-16-2013

Journal

Journal of Biological Chemistry

Volume

288

Issue

33

First Page

23807

Last Page

23813

URL with Digital Object Identifier

10.1074/jbc.M112.436279

Abstract

Background: TrkA is a transmembrane receptor tyrosine kinase for nerve growth factor. Results: TrkA forms a molecular complex with insulin receptor and IRS-1 to induce Akt and Erk5 phosphorylation. Conclusion: The NGF-TrkA receptor influences insulin signaling. Significance: The TrkA receptor is involved in insulin signaling, and NGF may regulate neuronal glucose uptake as neurons are insulin-insensitive. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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