Paediatrics Publications
Document Type
Article
Publication Date
8-1-2012
Journal
Journal of Cell Communication and Signaling
Volume
6
Issue
3
First Page
139
Last Page
153
URL with Digital Object Identifier
10.1007/s12079-012-0165-3
Abstract
Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain elusive. This review uncovers some of the molecular mechanisms underlying how normal physiology may be impaired in fetal and postnatal life due to maternal insults in pregnancy. By understanding the mechanisms, which include epigenetic, transcriptional, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS), we also highlight how intervention in fetal and neonatal life may be able to prevent these diseases long-term. © The International CCN Society 2012.