Latest advances in intervertebral disc development and progenitor cells

Authors

Cheryle A. Séguin, Schulich School of Medicine & DentistryFollow
Danny Chan, The University of Hong Kong Li Ka Shing Faculty of Medicine
Chitra L. Dahia, Weill Cornell Medicine
Zulma Gazit, Cedars-Sinai Medical Center

Document Type

Article

Publication Date

9-1-2018

Journal

JOR Spine

Volume

1

Issue

3

URL with Digital Object Identifier

10.1002/jsp2.1030

Abstract

This paper is a concise review aiming to assemble the most relevant topics presented by the authors at ORS-Philadelphia Spine Research Society Fourth International Spine Research Symposium. It centers on the latest advances in disc development, its main structural entities, and the populating cells, with emphasis on the advances in pivotal molecular pathways responsible for forming the intervertebral discs (IVD). The objective of finding and emphasizing pathways and mechanisms that function to control tissue formation is to identify and to explore modifications occurring during normal aging, disease, and tissue repair. Thus, to comprehend that the cellular and molecular basis of tissue degeneration are crucial in the study of the dynamic interplay that includes cell-cell communication, gene regulation, and growth factors required to form a healthy and functional tissue during normal development.