Predisposition to epilepsy - Does the ABCB1 gene play a role?

Authors

Laila Nurmohamed, Hospital for Sick Children University of Toronto
Facundo Garcia-Bournissen, Hospital for Sick Children University of TorontoFollow
Russell J. Buono, Thomas Jefferson University
Michael W. Shannon, Children's Hospital Boston
Yaron Finkelstein, Hospital for Sick Children University of Toronto

Document Type

Article

Publication Date

9-1-2010

Journal

Epilepsia

Volume

51

Issue

9

First Page

1882

Last Page

1885

URL with Digital Object Identifier

10.1111/j.1528-1167.2010.02588.x

Abstract

We performed a meta-analysis to evaluate the association between ABCB1 C3435T polymorphisms and the prevalence of epilepsy, including all relevant human studies (until June 2009), in which patients with or without epilepsy had undergone genotyping for the ABCB1 gene. Odds ratios (ORs) were calculated using a random effects model. We identified 9 case-control studies that included a total of 3,996 patients (2,454 with epilepsy and 1,542 nonepileptic subjects). No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34). ABCB1 genotyping for epileptic patients is not warranted. © 2010 International League Against Epilepsy.